Protein Alignment Usp32 and USP15

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001239007.1
• Gene: USP15 / 9958
• HGNCID: 12613
• Length: 981
• Species: Homo sapiens
• Alignment Length: 1442
• Identity: 313/1442 - (21%)
• Similarity: 492/1442 - (34%)
• Gaps: 569/1442 - (39%)

  Fly   400 RVGQFWYLITHDWWLSWMQYTQHTTHTCDYCKRTASQRTAVDEALVCDESFNTHSLEQHDSYSLG 464
            |.|..|||:...|:..|.:|.                                 ..:..|.|.:|
Human    25 RKGDTWYLVDSRWFKQWKKYV---------------------------------GFDSWDKYQMG 56

  Fly   465 SGTGSASGSGSASSGISAGRHCGPVRPGPIDNSNLITANPFRNVRTLTGEGGHLKRDTPLVQNHD 529
            ...                     |.|||||||.|:.          .|:...||..  |:...|
Human    57 DQN---------------------VYPGPIDNSGLLK----------DGDAQSLKEH--LIDELD 88

  Fly   530 FELVPKSLWKALNRWY----GDNLPLPRQVIQPPN--SDVELELYPLNLRILLHQAQPSQTGVGG 588
            :.|:|...|..|..||    |.. |:.|:|::...  ...::|:|...|::
Human    89 YILLPTEGWNKLVSWYTLMEGQE-PIARKVVEQGMFVKHCKVEVYLTELKL-------------- 138

  Fly   589 GTQLGSWGSTVSGGYGVLASGGGYAAIAVSSVLQPPKRYLAYTAAFSRLATVRQVGEFLCEQLRL 653
             .:.|:..:.|                               |..||:..|:..:.:.:.:...:
Human   139 -CENGNMNNVV-------------------------------TRRFSKADTIDTIEKEIRKIFSI 171

  Fly   654 KSE-DIRLWHVPQLDNGAILLEEDAMCLKELLIRDNDQLLLEIRNKDLTWPEELGSLATAQCGQG 717
            ..| :.|||: ..:.|....|.:....:::..:.....|::|.:|:|.|||            :|
Human   172 PDEKETRLWN-KYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWP------------RG 223

  Fly   718 AGTP--------GDRRRLTRSSIMSVH----------------------------------APGA 740
            ..||        ....:::.||:.:.:                                  .||.
Human   224 PSTPKSPGASNFSTLPKISPSSLSNNYNNMNNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGL 288

  Fly   741 TGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWTAT 805
            .||.|||||||||:|:|.|.||.||.:||..:.::.|:|..|.||.:|::|..||||:|::|:..
Human   289 CGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGK 353

  Fly   806 TRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPDKIV 870
            ...|.|...:..|.::||||:|..|.|.||||.:|||.|||||||:.:|||.:|||::|||||:|
Human   354 FSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVV 418

  Fly   871 AAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILL 935
            |.|||..|..||.|||:|:|:|..||.:.|..|...||.||||..|:||||::.....||.::.:
Human   419 AEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRM 483

  Fly   936 DG-SVPIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLRT-QSAKE 998
            |. :.|::|...:........|...||.:..:|.:.|:|.:::|.:..::...||.|.: ....:
Human   484 DPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDD 548

  Fly   999 LYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSH-------RAS 1056
            :||:::                                       :::..:.:.|       |..
Human   549 IYVFEI---------------------------------------NINRTEDTEHVIIPVCLREK 574

  Fly  1057 SRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCF 1121
            .|.....|.:|..:.|:                 |.:.....|.:.| :::.||.....:..:..
Human   575 FRHSSYTHHTGSSLFGQ-----------------PFLMAVPRNNTED-KLYNLLLLRMCRYVKIS 621

  Fly  1122 GKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSME 1186
            .:.|....||.|.|:..|..:.|..                  :|.|.:.|.|    .:.|...|
Human   622 TETEETEGSLHCCKDQNINGNGPNG------------------IHEEGSPSEM----ETDEPDDE 664

  Fly  1187 SSLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQP 1251
            ||..:.:|                      |.|::|                |:|:....|:|..
Human   665 SSQDQELP----------------------SENENS----------------QSEDSVGGDNDSE 691

  Fly  1252 DQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPNSE 1316
            :.:.|.  :|..|.                              |:.||.|...|..     |:.
Human   692 NGLCTE--DTCKGQ------------------------------LTGHKKRLFTFQF-----NNL 719

  Fly  1317 GGTHKDLYCAVWLQVSRLLSPLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSF 1381
            |.|                        ..|:..|....:.:|.    |.::.|
Human   720 GNT------------------------DINYIKDDTRHIRFDD----RQLRLD------------ 744

  Fly  1382 CRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTTKYFE 1446
                                                                            |
Human   745 ----------------------------------------------------------------E 745

  Fly  1447 DFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEP----VDLNHCLRAFTSEEKL---E 1504
            ...:|:||||......:.......:..||::     |...|    |.|..|:..||::|||   :
Human   746 RSFLALDWDPDLKKRYFDENAAEDFEKHESV-----EYKPPKKPFVKLKDCIELFTTKEKLGAED 805

  Fly  1505 QWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPYLASVP 1569
            .|| |.:||..:.|||||.:|.|||:|:||||||:.......|...:|.||.:|.|.:.:|.:
Human   806 PWY-CPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLIN-- 867

  Fly  1570 QETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTKATASPPPTGNILR 1634
                                                        ||        |.|
Human   868 --------------------------------------------PN--------AGP-------- 872

  Fly  1635 QSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYAVVSHSGMLNGGHYI 1699
                                                        .||.|.||.:|.|.:.||||.
Human   873 --------------------------------------------CRYNLIAVSNHYGGMGGGHYT 893

  Fly  1700 SYASNA-TGSWYCYNDSSCREISQKPVIDPSAAYLLFYERK----GLDYEPYLPNIEGRTLPNTA 1759
            ::|.|. .|.||.::|||....|:..::. .|||:|||:|:    |..:.|.....:|.:.  ..
Human   894 AFAKNKDDGKWYYFDDSSVSTASEDQIVS-KAAYVLFYQRQDTFSGTGFFPLDRETKGASA--AT 955

  Fly  1760 SVPLEVDETEGE 1771
            .:|||.||...:
Human   956 GIPLESDEDSND 967

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	166/566 (29%)
		Peptidase_C19	<1480..1737	CDD:470612	67/264 (25%)
USP15	NP_001239007.1	Mediates interaction with SART3. /evidence=ECO:0000269|PubMed:24526689	2..223		57/323 (18%)
		UBP12	12..932	CDD:227847	304/1403 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..237		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	629..694		22/124 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	952..981		5/18 (28%)