Protein Alignment Usp32 and USP10

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001259004.1
• Gene: USP10 / 9100
• HGNCID: 12608
• Length: 802
• Species: Homo sapiens
• Alignment Length: 831
• Identity: 162/831 - (19%)
• Similarity: 263/831 - (31%)
• Gaps: 350/831 - (42%)

  Fly  1056 SSRVLCNGH--------VSGLDVE--GEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELL 1110
            |:..|.|||        ||..|.|  |:.........|||..|     ||        :.|.:::
Human   176 STEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQN-----ST--------DSVSDIV 227

  Fly  1111 PDE-----AGKVSRCFGKRECMPHSLF---CFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHT 1167
            ||.     .|..:|..|:.|..|.:.|   ||.     :.:..:|....|.||       ..:.|
Human   228 PDSPFPGALGSDTRTAGQPEGGPGADFGQSCFP-----AEAGRDTLSRTAGAQ-------PCVGT 280

  Fly  1168 ESNTSSMSYTN-----HSGE----NSMESSLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSG 1223
            :: |.::...|     .|||    |.:|...||.|   ||:|....:.|         .|.|.:|
Human   281 DT-TENLGVANGQILESSGEGTATNGVELHTTESI---DLDPTKPESAS---------PPADGTG 332

  Fly  1224 LSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTSQPETSSGV-YSRRSSQPPH------------ 1275
            .::| ||..|     |.:...:..||       |:|.:||.| |......||.
Human   333 SASG-TLPVS-----QPKSWASLFHD-------SKPSSSSPVAYVETKYSPPAISPLVSEKQVEV 384

  Fly  1276 KAG-----------------KYLVAVHRKIT----------------------------RHDSYF 1295
            |.|                 :.:..:|:.::                            .|...|
Human   385 KEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKF 449

  Fly  1296 LS-YHKTRPSLFGVPLL--------------IPNS--------------EGGTHKDLYCAVWLQV 1331
            :. |.|.:......|::              :|..              .|...:..|      :
Human   450 IPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTY------I 508

  Fly  1332 SRLLSPLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQ 1396
            .|||:...::..:.....|.::.||    |.|..:..:.|.                      |:
Human   509 YRLLTVNKSSLSEKGRQEDAEEYLG----FILNGLHEEMLN----------------------LK 547

  Fly  1397 GALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYT------------------ASLSYTPTTK 1443
            ..|.|.|...:.::.||.:    |:...|.:...|.:                  |....||.|.
Human   548 KLLSPSNEKLTISNGPKNH----SVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITG 608

  Fly  1444 YFEDFTIAIDWDPTALHLRYQSTLE---RLWVDHETIAI-SRREQVEPVDLNHCLRAFTSEEKLE 1504
            .|.....::.:..::   :..:||:   .|.:|.::..| :.::.:|.:.....::.:|::.|.|
Human   609 IFGGHIRSVVYQQSS---KESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQE 670

  Fly  1505 QWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKV---VHFPFDDFDPTPYLA 1566
                       ...::::.:.||||:|::|||||  |..|....||:   :.:|.|
Human   671 -----------VEISRRVTLEKLPPVLVLHLKRF--VYEKTGGCQKLIKNIEYPVD--------- 713

  Fly  1567 SVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTKATASPPPTGN 1631
                         ||:                       |||:              .||
Human   714 -------------LEI-----------------------SKEL--------------LSP----- 723

  Fly  1632 ILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYAVVSHSG-MLNG 1695
               ..|.||                        :..||          .|||:|||.|.| ...|
Human   724 ---GVKNKN------------------------FKCHR----------TYRLFAVVYHHGNSATG 751

  Fly  1696 GHYIS--YASNATGSWYCYNDSSCREISQKPVIDPSA---AYLLFYERKGL 1741
            |||.:  :.....| |...:|.:.:.|:|..|:.|:|   ||||:|.|..|
Human   752 GHYTTDVFQIGLNG-WLRIDDQTVKVINQYQVVKPTAERTAYLLYYRRVDL 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847
		Peptidase_C19	<1480..1737	CDD:470612	56/265 (21%)
USP10	NP_001259004.1	UCH	419..796	CDD:425685	92/530 (17%)