DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp32 and USP2

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_004196.4	Gene:	USP2 / 9099	HGNCID:	12618	Length:	605	Species:	Homo sapiens

Alignment Length:	416	Identity:	116/416 - (27%)
Similarity:	181/416 - (43%)	Gaps:	88/416 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   706 LGSLATAQCGQGAGTPGDRRRLT--RSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQPLAQY 768
            :|.....:.|:|. .||..|..:  |..:.|..|.|..||.|||||||||:.||.|.||:.|..|
Human   231 IGRYTLWETGKGQ-APGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDY 294

  Fly   769 -----FQREMHRFEVNAANKLGTKGQLAM--RYAELLKEVWTATTRS-VAPLKLRFCVNKYAPQF 825
                 :.|::|.         |:....|:  .:|:|::.:||::... |:|.:.:..:.:|||:|
Human   295 CLQRLYMRDLHH---------GSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRF 350

  Fly   826 AGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLF 890
            .|..|.|:||.|.:|||.||.::|||..:|.|..::.:..||.....:.|.::..|..|.|.|||
Human   351 VGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLF 415

  Fly   891 YGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSH 955
            .|||||.::|..||:.|..||||..||||:....|.  ||.::                ||....
Human   416 VGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYP--EVTLM----------------DCMRLF 462

  Fly   956 LKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKL-------RTQSAKELYVYQLPEQSMRTRS 1013
            .|                        ..||:.|||.       |.:..|:..:.:.|:.
Human   463 TK------------------------EDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKI------ 497

  Fly  1014 NSGLSMHIEQGLKDIQRSSALITSAQDSLSSLS----TLQTSSHRASSRVLCNGHVSGLDVEGE- 1073
               |.:|:::..:...|:|.|.|.....|..|.    ..:.::|...:....:.| ||..:.|.
Human   498 ---LVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNH-SGTTMGGHY 558

  Fly  1074 ----AEVGTDVSQCNSNSNYNPIVST 1095
                ...||......::|:..|:.|:
Human   559 TAYCRSPGTGEWHTFNDSSVTPMSSS 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	97/312 (31%)
		Peptidase_C19	<1480..1737	CDD:351799
USP2	NP_004196.4	Necessary for interaction with MDM4. /evidence=ECO:0000269\|PubMed:19838211	1..200
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..264		7/27 (26%)
		UCH	266..596	CDD:278850	106/380 (28%)
		Peptidase_C19R	268..597	CDD:239139	106/378 (28%)
		Necessary for interaction with MDM4. /evidence=ECO:0000269\|PubMed:19838211	403..503		39/150 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920