Protein Alignment Usp32 and USP6

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_004496.2
• Gene: USP6 / 9098
• HGNCID: 12629
• Length: 1406
• Species: Homo sapiens
• Alignment Length: 1403
• Identity: 430/1403 - (30%)
• Similarity: 605/1403 - (43%)
• Gaps: 459/1403 - (32%)

  Fly   496 NSNLITANPFRNVRTLTGEGGHLKRDTPLVQNHDFELVPKSL-----WKALNRWYGDNLP-LPRQ 554
            |.:.:..:...:.:.||.:.|.|   .|..:.....|.|:.:     .|.|.:.|....| .|.|
Human   334 NDDTVLKHLRASTKKLTRKQGDL---PPPAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQ 395

  Fly   555 VIQP----------------PNSDVELELYPLNLRILLHQAQPSQTGVGGGTQLGSWGSTVSGGY 603
            ..:|                |...|..:.||:..     |..||.....||.| |||
Human   396 FQRPICSASPPWASRFSTPCPGGAVREDTYPVGT-----QGVPSLALAQGGPQ-GSW-------- 446

  Fly   604 GVLASGGGYAAIAVSSVLQPPKRYLAYTAAFSRLATVRQVG---------EFLCEQLRLKSEDIR 659
                                  |:|.: .:..||.|...:|         |:.|....:..||
Human   447 ----------------------RFLEW-KSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQED-- 486

  Fly   660 LWHVPQLDNGAILLEEDAMCLKELLIRDNDQLLLEIRNKDLTWPEELGSLATAQCGQGAGTPGDR 724
                 ||          |.|.:.       :...|:.|||::||||:...|.:       :..||
Human   487 -----QL----------ATCWQA-------EHCGEVHNKDMSWPEEMSFTANS-------SKIDR 522

  Fly   725 RRLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQ 789
            :::....       |||||.|||||||||:::|.:.|||||.|||....|.:|:|..|.:|.||.
Human   523 QKVPTEK-------GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGH 580

  Fly   790 LAMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEK 854
            :|..|.:|::|:|:.|.:||||||||..:.||||:|.|..|.||||||.:|||.||||||||.||
Human   581 MAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEK 645

  Fly   855 PYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLP 919
            ||.|||||:||||..||||||..|..||:|||:|||:|||:|:|.|..|||.|||||||:.||||
Human   646 PYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLP 710

  Fly   920 LPVENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQV 984
            ||:::|:..|:.||.|||:.|::||.|||.|.||:.||.:|..:|.|....:|:.|:.:|.|:..
Human   711 LPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNF 775

  Fly   985 LNDDEKLRTQSAKELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQ 1049
            ..|::|::...:..|..:::|..|
Human   776 PQDNQKVQLSVSGFLCAFEIPVPS----------------------------------------- 799

  Fly  1050 TSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEA 1114
                                                    :||      :.|...|:.
Human   800 ----------------------------------------SPI------SASSPTQID------- 811

  Fly  1115 GKVSRCFGKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNH 1179
                                     .||||                         :|:.|.....
Human   812 -------------------------FSSSP-------------------------STNGMFTLTT 826

  Fly  1180 SGENSMESSLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGN 1244
            :|:          :|    :|:...||.........|..|.::|:..||.  .||
Human   827 NGD----------LP----KPIFIPNGMPNTVVPCGTEKNFTNGMVNGHM--PSL---------- 865

  Fly  1245 AEDHDQPDQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVP 1309
                  ||...|.                      |::|||||:.|.:.||||..:.||||||:|
Human   866 ------PDSPFTG----------------------YIIAVHRKMMRTELYFLSPQENRPSLFGMP 902

  Fly  1310 LLIPNSEGGTHKDLYCAVWLQVSRLLSPLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCA 1374
            |::|.:.....||||.|||:|||.|..||| ..|.:.||.|.|:.:||.:|||||.|:.||.:||
Human   903 LIVPCTVHTRKKDLYDAVWIQVSWLARPLP-PQEASIHAQDRDNCMGYQYPFTLRVVQKDGNSCA 966

  Fly  1375 ICPWSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYT 1439
            .||...|||||:|.|..|....|                 ||
Human   967 WCPQYRFCRGCKIDCGEDRAFIG-----------------NA----------------------- 991

  Fly  1440 PTTKYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEEKL- 1503
                     .||:||.|||||||||::.||:...||::..|||.|.||::|:.|||||||||:|
Human   992 ---------YIAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTSEEELG 1047

  Fly  1504 -EQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPYLAS 1567
             .:.|:||.||....|||||.:|:|||.||:|||||..||.:|:||||:|.|..:.|||:.:|
Human  1048 ESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRESFDPSAFL-- 1110

  Fly  1568 VPQETIL-RHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEEL------------------ 1613
            ||::..| :||.|....::......   :..|:.::||.|...||::
Human  1111 VPRDPALCQHKPLTPQGDELSKPRI---LAREVKKVDAQSSAGKEDMLLSKSPSSLSANISSSPK 1172

  Fly  1614 ------------------------PNQTGSTKATASPPPTGNILRQSKTK--------------- 1639
                                    |...|.:|.....|..|:..:.|.:|
Human  1173 GSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKPSSSKKNLDASKENGAGQIC 1237

  Fly  1640 ---NAVRR--------QRLISTSLTKTPIVDGEFEDY------------------HQHRLKPDVD 1675
               :|:.|        ..|::....:..:.:|...::                  |......|..
Human  1238 ELADALSRGHMRGGSQPELVTPQDHEVALANGFLYEHEACGNGCGDGYSNGQLGNHSEEDSTDDQ 1302

  Fly  1676 QFD----PRYRLYAVVSHSGMLNGGHYISYASNATGSWYCYNDSSCREISQKPVIDPSAAYLLFY 1736
            :.|    |.|.|||:..|||:|:|||||:||.|....|||||||||.|: ....||..:||:|||
Human  1303 REDTHIKPIYNLYAISCHSGILSGGHYITYAKNPNCKWYCYNDSSCEEL-HPDEIDTDSAYILFY 1366

  Fly  1737 ERKGLDYEPYLPNIEGRTLPNTASVPLEVDETEGELKK 1774
            |::|:||..:||.|:|:.:.:|:|..   :::|.:.:|
Human  1367 EQQGIDYAQFLPKIDGKKMADTSSTD---EDSESDYEK 1401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	199/536 (37%)
		Peptidase_C19	<1480..1737	CDD:470612	110/349 (32%)
USP6	NP_004496.2	TBC	97..312	CDD:214540
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..380		7/34 (21%)
		UBP12	<528..1114	CDD:227847	307/842 (36%)
		Peptidase_C19	<1029..1366	CDD:470612	105/342 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1120..1231		16/113 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1384..1406		4/21 (19%)