DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and DOA4

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_010354.3	Gene:	DOA4 / 851641	SGDID:	S000002476	Length:	926	Species:	Saccharomyces cerevisiae

Alignment Length:	1067	Identity:	215/1067 - (20%)
Similarity:	358/1067 - (33%)	Gaps:	397/1067 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 CNDAGTFI-IKSDYVRNVNLAPFESVSLFAQSERVNFEQFQDWIIKHRNATVLSKWLLSD--NCV 167
            |.:.|..| ..|..:..:|...::.:.:...:...:..:|..  ||...:|       ||  |..
Yeast    75 CKNKGAMISSNSVMIIQLNYVYYKVIHIIVTTNIPHLSEFAK--IKLHKST-------SDEGNGN 130

  Fly   168 SLTSELETPTFYQSLAGVTHLEEKDIGDLEKEFWR--LKNTSQN---GQIDLQFLGPLISPPIPK 227
            :..:|.:....|.:|. .|.|::::|..: |.|.:  :|.|..|   .:.:|...|..|:    .
Yeast   131 NNNNEFQLMNIYNTLL-ETLLKDENIAKI-KSFIKSSIKQTKLNHEQEECNLMRTGSYIT----S 189

  Fly   228 NALAGLFNA-------------FD-----ENRDGHIDFKELCCGVSAACRGPGVERTRFCFKIFD 274
            |.|..|.::             .|     |....|||.|.:.|          :|...|.....|
Yeast   190 NQLNSLISSSANSASSQMEILLIDIRSRLEFNKSHIDTKNIIC----------LEPISFKMSYSD 244

  Fly   275 VDRDGVLSHDETLQMINVLLLVAKENQESQ--QYKDLTKQLVI-SDLLEFGQRRSPDGTPSKLTR 336
                    ||     :....|:...|.|.:  |.::|.|.::: :|..|:
Yeast   245 --------HD-----LEKKSLITSPNSEIKMFQSRNLFKFIILYTDANEY--------------- 281

  Fly   337 DNVSLTAEDFMLWTVQCDLRLMQPLLDLI----FELCHIVFGLWPQCKHMENDIVR--------- 388
                             :::....|||::    ||            |.:.:|..:
Yeast   282 -----------------NVKQQSVLLDILVNHSFE------------KPISDDFTKIFILESGFP 317

  Fly   389 GWLRREERRPYRVGQFW-----------YLITHDWWLSWMQYTQHTTHTCDYCKRTASQRTAVD- 441
            |||:....|  :|...:           |:..:...||    .||..      |.:.|.|.::|
Yeast   318 GWLKSNYGR--QVSSSFPSNNNIKDDSVYINGNTSGLS----LQHLP------KMSPSIRHSMDD 370

  Fly   442 ---EALVC------------DESFNTHSLEQHDSY-SLGSGTGSASGSGSAS-----SGISAGRH 485
               |.||.            .:|.|.|.|::..|: .|.|...|.:...|.|     |.:|....
Yeast   371 SMKEMLVAPTPLNHLQQQQQQQSDNDHVLKRSSSFKKLFSNYTSPNPKNSNSNLYSISSLSISSS 435

  Fly   486 CGPV---RPGPIDNSNLITANPFRNVRTLTGEGGHLKRDTPLVQNHDFELVPKSLWKALNRWYGD 547
            ..|:   .|.|:..::|....|                :||            .|||....   |
Yeast   436 PSPLPLHSPDPVKGNSLPINYP----------------ETP------------HLWKNSET---D 469

  Fly   548 NLPLPRQVIQPPNSDVELELYPLNLRILLHQAQPSQTGVGGGTQLGSWGSTVSGGYGVLASGGGY 612
            .:...|:.:   |.:....:.|:|.:.:   ..||:|..   .:|..:..|:|....:.::|...
Yeast   470 FMTNQREQL---NHNSFAHIAPINTKAI---TSPSRTAT---PKLQRFPQTISMNLNMNSNGHSS 525

  Fly   613 AAIAVSSVLQPPKRYLAYTAAFSRLATVRQVGEFLCEQLRLKSEDIRLWHVPQLDNGAILLEEDA 677
            |    :|.:||
Yeast   526 A----TSTIQP------------------------------------------------------ 532

  Fly   678 MCLKELLIRDNDQLLLEIRNKDLTWPEELGSLATAQCGQGAGTPGDRRRLTRSSIMSVHAPGATG 742
            .||.   :.:||.|                               |...:|.:|..:.....|.|
Yeast   533 SCLS---LSNNDSL-------------------------------DHTDVTPTSSHNYDLDFAVG 563

  Fly   743 LHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELL-----KEVW 802
            |.||||:|:||..:|.:..|..|.|.|..:.:...:|..:|||:||.||..:|.|:     ::|.
Yeast   564 LENLGNSCYMNCIIQCILGTHELTQIFLDDSYAKHININSKLGSKGILAKYFARLVHMMYKEQVD 628

  Fly   803 TATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRV-MEKPYSEL-KDSNGR 865
            .:...|::|:|.:.........|....|.|.||..::|||.||||||:. ...|..|| :::..|
Yeast   629 GSKKISISPIKFKLACGSVNSLFKTASQQDCQEFCQFLLDGLHEDLNQCGSNPPLKELSQEAEAR 693

  Fly   866 PDK----IVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYI 926
            .:|    |.::..|.:....:.|:|:|||.||..|::.|..|.|.|..:.||::||:|:|.:|
Yeast   694 REKLSLRIASSIEWERFLTTDFSVIVDLFQGQYASRLKCKVCSHTSTTYQPFTVLSIPIPKKN-- 756

  Fly   927 YFEVLVILLDGSVPIKYGFR--------------LNSDCKYSHLKHKLSTMCSLPPNLML----- 972
                    ...::.|:..||              |...|:......|..|:..||.||::
Yeast   757 --------SRNNITIEDCFREFTKCENLEVDEQWLCPHCEKRQPSTKQLTITRLPRNLIVHLKRF 813

  Fly   973 ------------------VCELWNSQIRQV----LNDDE-KLRTQSAK---ELYVYQLPEQSMRT 1011
                              :...|.:....|    :|||| .:|.|...   |||
Yeast   814 DNLLNKNNDFVIYPFLLDLTPFWANDFDGVFPPGVNDDELPIRGQIPPFKYELY----------- 867

  Fly  1012 RSNSGLSMH------------IEQGLK 1026
                |::.|            :::|||
Yeast   868 ----GVACHFGTLYGGHYTAYVKKGLK 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455	32/156 (21%)
		UBP12	486..>1002	CDD:227847	125/574 (22%)
		Peptidase_C19	<1480..1737	CDD:351799
DOA4	NP_010354.3	RHOD	208..324	CDD:197731	30/182 (16%)
DOA4	NP_010354.3	COG5533	495..924	CDD:227820	115/516 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010