DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp32 and USP45

DIOPT Version :9

Sequence 1:NP_001262074.2 Gene:Usp32 / 40169 FlyBaseID:FBgn0036913 Length:1779 Species:Drosophila melanogaster
Sequence 2:NP_001073950.1 Gene:USP45 / 85015 HGNCID:20080 Length:814 Species:Homo sapiens


Alignment Length:739 Identity:171/739 - (23%)
Similarity:249/739 - (33%) Gaps:271/739 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   742 GLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTK--------GQLAMRYAEL- 797
            |:.|||||||.||.:|.|..|..|...         :|...:..||        .||.....|| 
Human   191 GITNLGNTCFFNAVMQNLAQTYTLTDL---------MNEIKESSTKLKIFPSSDSQLDPLVVELS 246

  Fly   798 ---------------LKEVWTATTRSVAPLKLRFCVNKY---APQFAGGGQHDSQELLEWLLDAL 844
                           :||.      ...||..:...|:.   ||:|....|.||||||.:||||:
Human   247 RPGPLTSALFLFLHSMKET------EKGPLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAV 305

  Fly   845 H-EDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHARNQ-----SIIIDLFYGQLKSKVSCLGC 903
            . |:..|:..   |.||..|....|....|...:..|..:     :.|..:|.|:|.|.|.|..|
Human   306 RTEETKRIQA---SILKAFNNPTTKTADDETRKKVKAYGKEGVKMNFIDRIFIGELTSTVMCEEC 367

  Fly   904 GHESVRFDPFSLLSLPLPVENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSHL------------ 956
            .:.|...|||..:|||: :|..:           |.|:.:| |:|   ||..|            
Human   368 ANISTVKDPFIDISLPI-IEERV-----------SKPLLWG-RMN---KYRSLRETDHDRYSGNV 416

  Fly   957 ------------KHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLRTQSAKELYVYQLPEQSM 1009
                        ||..|...|                 |:::|.:.:|..|:.|...||      
Human   417 TIENIHQPRAAKKHSSSKDKS-----------------QLIHDRKCIRKLSSGETVTYQ------ 458

  Fly  1010 RTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQT-SSHRASSRVLCNGHVSGLDVEGE 1073
               .|..|.|:         ..|.:..|..:|.|.|:...| .|.:.:|.           .|..
Human   459 ---KNENLEMN---------GDSLMFASLMNSESRLNESPTDDSEKEASH-----------SESN 500

  Fly  1074 AEVGTDVSQCNSNSNYNPIVSTYSGNG----------------------SGDNQVHELLPDEAGK 1116
            .:..::.|:..|.|....:..:.||:|                      |||.::.|.: .|...
Human   501 VDADSEPSESESASKQTGLFRSSSGSGVQPDGPLYPLSAGKLLYTKETDSGDKEMAEAI-SELRL 564

  Fly  1117 VSRCFG----KRECMPHSL---FCFKESLILSS-SPENTFMHGAAAQQKRVSSAKLLHTESNTSS 1173
            .|...|    .||..|.::   .||.|...|.| ||:|.|                     .|.|
Human   565 SSTVTGDQDFDRENQPLNISNNLCFLEGKHLRSYSPQNAF---------------------QTLS 608

  Fly  1174 MSYTNHSGENSMESSLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDE 1238
            .||...|.|.|::|.|.:   ...:|.:...|....|:|:                         
Human   609 QSYITTSKECSIQSCLYQ---FTSMELLMGNNKLLCENCT------------------------- 645

  Fly  1239 QAEEGNAEDHDQPDQITTSQPETS-SGVYSRRSSQ------PP---------HKAGKYLVAVHRK 1287
                    .:.|..|..||..|.. .|||:....|      |.         |:||..|    ||
Human   646 --------KNKQKYQEETSFAEKKVEGVYTNARKQLLISAVPAVLILHLKRFHQAGLSL----RK 698

  Fly  1288 ITRHDSY--------FLSYHKTRPS-----LFGVPLLIPNSEGGTHKDLYCAVWLQV---SRLLS 1336
            :.||..:        |.|......|     |:|:..::.:|  |:.::.:...:::|   ||.||
Human   699 VNRHVDFPLMLDLAPFCSATCKNASVGDKVLYGLYGIVEHS--GSMREGHYTAYVKVRTPSRKLS 761

  Fly  1337 PLPATTEQAN----HAADCDDSLG 1356
              ...|::.|    .||| ::|.|
Human   762 --EHNTKKKNVPGLKAAD-NESAG 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp32NP_001262074.2 FRQ1 186..317 CDD:227455
UBP12 486..>1002 CDD:227847 82/316 (26%)
Peptidase_C19 <1480..1737 CDD:351799
USP45NP_001073950.1 Interaction with ERCC1. /evidence=ECO:0000269|PubMed:25538220 1..62
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
zf-UBP 62..132 CDD:280334
Peptidase_C19 191..>387 CDD:271592 64/214 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..443 5/41 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 479..533 12/64 (19%)
Peptidase_C19K <603..811 CDD:239132 51/246 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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