DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp32 and USP32

DIOPT Version :9

Sequence 1:NP_001262074.2 Gene:Usp32 / 40169 FlyBaseID:FBgn0036913 Length:1779 Species:Drosophila melanogaster
Sequence 2:XP_011523673.1 Gene:USP32 / 84669 HGNCID:19143 Length:1634 Species:Homo sapiens


Alignment Length:1895 Identity:689/1895 - (36%)
Similarity:975/1895 - (51%) Gaps:438/1895 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 VSDVELRRLRDAFKKSAGVGRNFLSRNAFQQDVLCEGVPPKIVDMLYAACGGTQRGISFNDLLCG 85
            |:||||:||:||||::.|:. .::.::.|.::||.:|||||:.:::|.:.|||.:|:.||:|:.|
Human    36 VTDVELKRLKDAFKRTCGLS-YYMGQHCFIREVLGDGVPPKVAEVIYCSFGGTSKGLHFNNLIVG 99

  Fly    86 LVLITRGTQAEKTKFLWNLYCNDAGTFIIKSDYVRNVNL----APFESVSLFAQSERVNFEQFQD 146
            |||:|||...||.|::::|:.:::|.::|:.:..|.:::    .|......|::.|:||:|:|::
Human   100 LVLLTRGKDEEKAKYIFSLFSSESGNYVIREEMERMLHVVDGKVPDTLRKCFSEGEKVNYEKFRN 164

  Fly   147 WIIKHRNATVLSKWLLSDNC-VSLTSELETPTFYQSLAGVTHLEEKDIGDLEKEFWRLKNTSQNG 210
            |:..:::|...|:||||... |:||.:.:||||||:|||||||||.||.||||.:|.||..|:.|
Human   165 WLFLNKDAFTFSRWLLSGGVYVTLTDDSDTPTFYQTLAGVTHLEESDIIDLEKRYWLLKAQSRTG 229

  Fly   211 QIDLQFLGPLISPPIPKNALAGLFNAFDENRDGHIDFKELCCGVSAACRGPGVERTRFCFKIFDV 275
            :.||:..|||:||||..:...|||||||||||.||||||:.||:||.||||..||.:||||:|||
Human   230 RFDLETFGPLVSPPIRPSLSEGLFNAFDENRDNHIDFKEISCGLSACCRGPLAERQKFCFKVFDV 294

  Fly   276 DRDGVLSHDETLQMINVLLLVAKENQESQQYKDLTK-QLVISDLLEFGQRRSPDGTPSKLTRDNV 339
            |||||||..|...|:..||.|.|:|:..    |:.: .:.:||::| |...:.|.|  |:..   
Human   295 DRDGVLSRVELRDMVVALLEVWKDNRTD----DIPELHMDLSDIVE-GILNAHDTT--KMGH--- 349

  Fly   340 SLTAEDFMLWTVQCDLRLMQPLLDLIFELCHIVFGLWPQCKHMENDIVRGWLRREERRPYRVGQF 404
             ||.||:.:|:|:  ..|....|:|:|::||||.||.|.....|..|:||||.||.|...:.|..
Human   350 -LTLEDYQIWSVK--NVLANEFLNLLFQVCHIVLGLRPATPEEEGQIIRGWLERESRYGLQAGHN 411

  Fly   405 WYLITHDWWLSWMQYTQHTTHTC-----------DYCKRTASQ-RTAVDEALVCDESF-NTHSLE 456
            |::|:..||..|.:|.::..:..           .|...||:. ...|::.:....|: ||...:
Human   412 WFIISMQWWQQWKEYVKYDANPVVIEPSSVLNGGKYSFGTAAHPMEQVEDRIGSSLSYVNTTEEK 476

  Fly   457 QHDSYSLGSGTGSASGSG---SASSGISA--------------------GR---HCGPVRPGPID 495
            ..|:.|..|.....:|||   ||:.|...                    |.   |..|.:||.||
Human   477 FSDNISTASEASETAGSGFLYSATPGADVCFARQHNTSDNNNQCLLGANGNILLHLNPQKPGAID 541

  Fly   496 NSNLITANPFRNVRTLTGEGGHLKRDTPLVQNHDFELVPKSLWKALNRWYGDNLPLPRQVIQPPN 560
            |..|:|..|.: ..:||.|||.|||...|:...|:|:||:.:|:||..|||.||.|||.||:...
Human   542 NQPLVTQEPVK-ATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLALPRPVIKNSK 605

  Fly   561 SDV-ELELYPLNLRILLHQ----AQPSQTGVG-GGTQLGSWGSTVSGGYGVLASGGGYAAIAVSS 619
            :|: ||||:|..|..|..|    .|.|...|. |...|..:...:..|             .|.|
Human   606 TDIPELELFPRYLLFLRQQPATRTQQSNIWVNMGMMSLRMFPQHLPRG-------------NVPS 657

  Fly   620 VLQPPKRYLAYTAAFSRLATVRQVGEFLCEQLRLKSEDIRLWHVPQLDNGAILLEEDAMCLKELL 684
            ...|.||.||||..|||:.|::::.|:|.::||:|.||:||| :...:|...||:::...|:.|.
Human   658 PNAPLKRVLAYTGCFSRMQTIKEIHEYLSQRLRIKEEDMRLW-LYNSENYLTLLDDEDHKLEYLK 721

  Fly   685 IRDNDQLLLEIRNKDLTWPEELGSLATAQCGQGAGTPGDRRRLTRSSIMSVHAPGATGLHNLGNT 749
            |:|...|::|:||||::||||:..:|.:       :..||.::....       |||||.|||||
Human   722 IQDEQHLVIEVRNKDMSWPEEMSFIANS-------SKIDRHKVPTEK-------GATGLSNLGNT 772

  Fly   750 CFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWTATTRSVAPLKL 814
            ||||:::|.:.|||||.|||....|.:|:|..|.:|.||.:|..|.:|::|:|:.|.::||||||
Human   773 CFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKL 837

  Fly   815 RFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHH 879
            |:.:.||||:|.|..|.||||||.:|||.||||||||.||||.|||||:||||..||||||..|.
Human   838 RWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHL 902

  Fly   880 ARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILLDGSVPIKYG 944
            .||:||::|||:|||:|:|.|..|||.|||||||:.||||||:::|::.|:.||.|||:.|::||
Human   903 RRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPVRYG 967

  Fly   945 FRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLRTQSAKELYVYQLPEQSM 1009
            .|||.|.||:.||.:||.:|.|....:|:.|:..|.|:....|::|:|...:..|..:::|.   
Human   968 LRLNMDEKYTGLKKQLSDLCGLNSEQILLAEVHGSNIKNFPQDNQKVRLSVSGFLCAFEIPV--- 1029

  Fly  1010 RTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCNGHVSGLDVEGEA 1074
                                                                             
Human  1030 ----------------------------------------------------------------- 1029

  Fly  1075 EVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCFGKRECMPHSLFCFKESLI 1139
                            |:                                            |.|
Human  1030 ----------------PV--------------------------------------------SPI 1034

  Fly  1140 LSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSMESSLTEPIPLADLEPVSSR 1204
            .:|||                      |:::.||...||.....:....|..||.:.        
Human  1035 SASSP----------------------TQTDFSSSPSTNEMFTLTTNGDLPRPIFIP-------- 1069

  Fly  1205 NGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTSQPETSSGVYSRR 1269
            ||.........|..|.::|:..||.  .||                ||...|.            
Human  1070 NGMPNTVVPCGTEKNFTNGMVNGHM--PSL----------------PDSPFTG------------ 1104

  Fly  1270 SSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPNSEGGTHKDLYCAVWLQVSRL 1334
                      |::|||||:.|.:.||||..|.||||||:||::|.:.....||||.|||:|||||
Human  1105 ----------YIIAVHRKMMRTELYFLSSQKNRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSRL 1159

  Fly  1335 LSPLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGAL 1399
            .|||| ..|.:|||.|||||:||.:|||||.|:.||.:||.|||..|||||:|.|..|....|  
Human  1160 ASPLP-PQEASNHAQDCDDSMGYQYPFTLRVVQKDGNSCAWCPWYRFCRGCKIDCGEDRAFIG-- 1221

  Fly  1400 PPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTTKYFEDFTIAIDWDPTALHLRYQ 1464
                           ||                                .||:||||||||||||
Human  1222 ---------------NA--------------------------------YIAVDWDPTALHLRYQ 1239

  Fly  1465 STLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEEKL--EQWYHCSHCKGKKPATKKLQIWKL 1527
            ::.||:..:||::..|||.|.||::|:.|||||||||:|  .:.|:||.||....|||||.:|:|
Human  1240 TSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRL 1304

  Fly  1528 PPILIVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPYLASVPQETIL-RHKELL----EL----- 1582
            |||||:|||||..|||:|:||||:|.||.:.|||:.:|  ||::..| :||.|.    ||     
Human  1305 PPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFL--VPRDPALCQHKPLTPQGDELSEPRI 1367

  Fly  1583 ------KNDAEMTMATNEVV----------------------SELDEIDAPSKEVKEELPNQT-- 1617
                  |.||:.:....:|:                      |.......||.  |...||.:  
Human  1368 LAREVKKVDAQSSAGEEDVLLSKSPSSLSANIISSPKGSPSSSRKSGTSCPSS--KNSSPNSSPR 1430

  Fly  1618 --GSTKATASPPPTGNILRQSKTK------------------NAVRRQRLISTSLTK--TP---- 1656
              |.:|.....|..|:..:.|.:|                  :|:.|..::..|..:  ||    
Human  1431 TLGRSKGRLRLPQIGSKNKLSSSKENLDASKENGAGQICELADALSRGHVLGGSQPELVTPQDHE 1495

  Fly  1657 --IVDGEFEDYH------------QHRLKPDVD------QFDPRYRLYAVVSHSGMLNGGHYISY 1701
              :.:|...::.            .|..:...|      :..|.|.|||:..|||:|.||||::|
Human  1496 VALANGFLYEHEACGNGYSNGQLGNHSEEDSTDDQREDTRIKPIYNLYAISCHSGILGGGHYVTY 1560

  Fly  1702 ASNATGSWYCYNDSSCREISQKPVIDPSAAYLLFYERKGLDYEPYLPNIEGRTLPNTASVPLEVD 1766
            |.|....|||||||||:|: ....||..:||:||||::|:||..:||..:|:.:.:|:|:.   :
Human  1561 AKNPNCKWYCYNDSSCKEL-HPDEIDTDSAYILFYEQQGIDYAQFLPKTDGKKMADTSSMD---E 1621

  Fly  1767 ETEGELKKLC 1776
            :.|.:.||.|
Human  1622 DFESDYKKYC 1631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp32NP_001262074.2 FRQ1 186..317 CDD:227455 74/131 (56%)
UBP12 486..>1002 CDD:227847 239/521 (46%)
Peptidase_C19 <1480..1737 CDD:351799 118/344 (34%)
USP32XP_011523673.1 EF-hand_7 252..309 CDD:290234 41/56 (73%)
EFh 253..309 CDD:238008 40/55 (73%)
EF-hand_7 286..358 CDD:290234 33/82 (40%)
UBP12 534..1346 CDD:227847 412/1090 (38%)
DUSP <535..602 CDD:283896 33/67 (49%)
Ubiquitin_3 653..740 CDD:291502 37/100 (37%)
Peptidase_C19 765..>955 CDD:271592 115/189 (61%)
Peptidase_C19 <1255..1595 CDD:271592 118/344 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 670 1.000 Domainoid score I146
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H13066
Inparanoid 1 1.050 1140 1.000 Inparanoid score I215
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52451
OrthoDB 1 1.010 - - D1283205at2759
OrthoFinder 1 1.000 - - FOG0007271
OrthoInspector 1 1.000 - - otm41375
orthoMCL 1 0.900 - - OOG6_104647
Panther 1 1.100 - - LDO PTHR21646
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4685
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.980

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