Protein Alignment Usp32 and USP38

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_115946.2
• Gene: USP38 / 84640
• HGNCID: 20067
• Length: 1042
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 134/614 - (21%)
• Similarity: 225/614 - (36%)
• Gaps: 162/614 - (26%)

  Fly   702 WPEELGSLATAQCGQGAGTPGDRRRLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQPLA 766
            |..:..|||:.              |:|.|..|  ..|.|||.||||||:||:.:|.||    :|
Human   422 WTSQSNSLASC--------------LSRLSGKS--ETGKTGLINLGNTCYMNSVIQALF----MA 466

  Fly   767 QYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQH 831
            ..|:|::....:|..|.|       |:..:.|......|.|.....::.|..:: .|.|....|.
Human   467 TDFRRQVLSLNLNGCNSL-------MKKLQHLFAFLAHTQREAYAPRIFFEASR-PPWFTPRSQQ 523

  Fly   832 DSQELLEWLLDALHEDLNRVME-----KPYSELKDSNGRPDKIVAAEAWSQHHAR----NQSIII 887
            |..|.|.:|||.|||: .::::     ||...|:.|.....::.:..|......|    .:::|.
Human   524 DCSEYLRFLLDRLHEE-EKILKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIE 587

  Fly   888 DLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPL----PVENYIYFEVLVI-------LLDGSV-- 939
            .:|.|:|::.:.||.|...|.:.:.|:.|||..    .:||....:....       |:..||
Human   588 KMFGGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQDGGLMQASVPG 652

  Fly   940 ----PIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKL--------- 991
                |:.|.....:....|.:..|  |:.| |||     |.:.|:...|.|:..|:
Human   653 PSEEPVVYNPTTAAFICDSLVNEK--TIGS-PPN-----EFYCSENTSVPNESNKILVNKDVPQK 709

  Fly   992 ----RTQSAKELYVYQL-PE----------QSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQ-- 1039
                .|.|..:|..|.| ||          ::..:..|:..:|.|.:     :....::|..:
Human   710 PGGETTPSVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITE-----EPEYLILTLLRFS 769

  Fly  1040 ------------DSLSSLSTLQTSSHRASSRVLCNGHVSGLDVEGEAEV---------------- 1076
                        |::|....|:....|.:|       .|.|......:|
Human   770 YDQKYHVRRKILDNVSLPLVLELPVKRITS-------FSSLSESWSVDVDFTDLSENLAKKLKPS 827

  Fly  1077 GTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAG---KVSRCFGKRECMPHSLFCFKESL 1138
            |||.:.|.....|  ::|:.        .||..:..|:|   ..:|.....: ..:.::...|:|
Human   828 GTDEASCTKLVPY--LLSSV--------VVHSGISSESGHYYSYARNITSTD-SSYQMYHQSEAL 881

  Fly  1139 ILSSSPENTFMHGAAA-------QQKRVSSAKLLHTESNTSSMSYTNHSGENSMESSLTEPIPLA 1196
            .|:||..:.....:.:       :.|.:|....|.   |.|.:::|:......:.|...:.....
Human   882 ALASSQSHLLGRDSPSAVFEQDLENKEMSKEWFLF---NDSRVTFTSFQSVQKITSRFPKDTAYV 943

  Fly  1197 DL-EPVSSRNGSGGEDCSYRTSPNDSSGL 1224
            .| :...|.||..|.        |.:|||
Human   944 LLYKKQHSTNGLSGN--------NPTSGL 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	86/338 (25%)
		Peptidase_C19	<1480..1737	CDD:470612
USP38	NP_115946.2	Peptidase_C19H	446..947	CDD:239129	116/547 (21%)