Protein Alignment Usp32 and USP42

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001376579.1
• Gene: USP42 / 84132
• HGNCID: 20068
• Length: 1327
• Species: Homo sapiens
• Alignment Length: 1196
• Identity: 250/1196 - (20%)
• Similarity: 389/1196 - (32%)
• Gaps: 380/1196 - (31%)

  Fly   736 HAPGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKE 800
            |..|| ||.|||||||.|||||.|..|.|||.|.....|....:|      :|...|  ..:...
Human   107 HRVGA-GLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHA------EGFCMM--CTMQAH 162

  Fly   801 VWTATTRSVAPLKLRFCVN---KYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDS 862
            :..|.:.....:|..|.:|   :.|..|..|.|.|:.|.|::.:||:.:          :.|..|
Human   163 ITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQK----------ACLNGS 217

  Fly   863 NGRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPL------- 920
            |    |:       ..|.:..:::..:|.|.|:|:|.||.|...|..|||:..::|.:
Human   218 N----KL-------DRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVN 271

  Fly   921 -PVENYIYFEVLVILLDGS-----------VPIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLV 973
             .:|.::..|    .|||.           ||....|.:          |:.|.:.:|  :|...
Human   272 KALEQFVKPE----QLDGENSYKCSKCKKMVPASKRFTI----------HRSSNVLTL--SLKRF 320

  Fly   974 CELWNSQIRQVLNDDEKL-----RTQSAKELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSA 1033
            ......:|.:.:...|.|     .:|...|..||.|....:.|    |.:.|.......|:.|:.
Human   321 ANFTGGKIAKDVKYPEYLDIRPYMSQPNGEPIVYVLYAVLVHT----GFNCHAGHYFCYIKASNG 381

  Fly  1034 LITSAQDSLSSLSTLQT--------------------------------SSHR--ASSRVLCN-- 1062
            |.....||:.|.|.:::                                ||.|  .|.||:.|
Human   382 LWYQMNDSIVSTSDIRSVLSQQAYVLFYIRSHDVKNGGELTHPTHSPGQSSPRPVISQRVVTNKQ 446

  Fly  1063 ------------------GHVSGLDVEGEAEVGTDVSQCNSNSNYN---PI-----VSTYSGNGS 1101
                              .|::|.....:.. .:.:|..|.||:.|   |:     |..:|.|.|
Human   447 AAPGFIGPQLPSHMIKNPPHLNGTGPLKDTP-SSSMSSPNGNSSVNRASPVNASASVQNWSVNRS 510

  Fly  1102 GDNQVHELLPDEAGKVSRCFGKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLH 1166
                  .::|:...|..........:|... |..:..:.|:|.||        ..|.|.|:.:
Human   511 ------SVIPEHPKKQKITISIHNKLPVRQ-CQSQPNLHSNSLEN--------PTKPVPSSTI-- 558

  Fly  1167 TESNTSSMSYTNHSGENSMESSLTEPIPLAD--LEPV----SSRNGS-----GGEDCSYRTSPND 1220
               ..|::..|:::...|:.|.:|:|||.::  .:||    |..|.|     |.|  |...|..:
Human   559 ---TNSAVQSTSNASTMSVSSKVTKPIPRSESCSQPVMNGKSKLNSSVLVPYGAE--SSEDSDEE 618

  Fly  1221 SSGLSTGHTLG---ASLDVDEQAEEGNAEDHDQPDQITTSQPETSSGVYSRRSSQPPHKAGKYLV 1282
            |.||...:.:|   :|....:.||:..|..|:      ..:|.|.:|..|..|...|.:.|
Human   619 SKGLGKENGIGTIVSSHSPGQDAEDEEATPHE------LQEPMTLNGANSADSDSDPKENG---- 673

  Fly  1283 AVHRKITRHDSYFLSYHKTRPSLFGVPLLIPNSEGGTHKDLYCAVWLQVSRLLSPLPATTEQANH 1347
                                                                |:|         .
Human   674 ----------------------------------------------------LAP---------D 677

  Fly  1348 AADC--DDSLGYDFPFTLRAVKADGLTCAICP-----------WSSFCRGCEIRCNNDYVLQGAL 1399
            .|.|  ..:|..:.||    .||:||...:.|           ..:|      |.:|.  |:|:.
Human   678 GASCQGQPALHSENPF----AKANGLPGKLMPAPLLSLPEDKILETF------RLSNK--LKGST 730

  Fly  1400 PPINAAASNTSTPK-MNAK-FPSLPNLEAKRTPEYTASLSYT---PTTKYFEDFTIAIDWDPTAL 1459
            ..::|..:....|: .:|: .|..|..|:...|:..|.||.|   |..:           ||..
Human   731 DEMSAPGAERGPPEDRDAEPQPGSPAAESLEEPDAAAGLSSTKKAPPPR-----------DPGT- 783

  Fly  1460 HLRYQSTLERLWVDHETIAISRRE-----------QVEPVDLNHCLRAFTSEEKLEQWYHCSHCK 1513
                .:|.|..|   |.:|::..|           ...|.||............|.|     ..|
Human   784 ----PATKEGAW---EAMAVAPEEPPPSAGEDIVGDTAPPDLCDPGSLTGDASPLSQ-----DAK 836

  Fly  1514 G---KKPATKKLQ-----IWKLPPI---------LIVHLKRFNCVNGKWVKSQKVVHFPFDDFDP 1561
            |   :.|....|.     :...||.         |:||      .:|...:         |..||
Human   837 GMIAEGPRDSALAEAPEGLSPAPPARSEEPCEQPLLVH------PSGDHAR---------DAQDP 886

  Fly  1562 T-----PYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPS-KEVKEELPN----Q 1616
            :     |..|..|...:|........:.|||  .:..|.|.:.....||. ...||::.:    .
Human   887 SQSLGAPEAAERPPAPVLDMAPAGHPEGDAE--PSPGERVEDAAAPKAPGPSPAKEKIGSLRKVD 949

  Fly  1617 TGSTKATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQ---HRLKPDVDQFD 1678
            .|..::......:|...|:|::|....|.|...|...:....|....::|.   .||.|     .
Human   950 RGHYRSRRERSSSGEPARESRSKTEGHRHRRRRTCPRERDRQDRHAPEHHPGHGDRLSP-----G 1009

  Fly  1679 PRYRLYAVVSHSGMLNGG-------HYISYASNATGSWYCYND----SSCREISQKPVIDPSAAY 1732
            .|..|.....|......|       |:.:......|....|.|    ..||....:..:..:..:
Human  1010 ERRSLGRCSHHHSRHRSGVELDWVRHHYTEGERGWGREKFYPDRPRWDRCRYYHDRYALYAARDW 1074

  Fly  1733 LLF-----YERKGLDYEPYLPNIEGR 1753
            ..|     :||.||...|:..:..||
Human  1075 KPFHGGREHERAGLHERPHKDHNRGR 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	75/292 (26%)
		Peptidase_C19	<1480..1737	CDD:470612	56/313 (18%)
USP42	NP_001376579.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..87
		Peptidase_C19E	110..410	CDD:239126	87/349 (25%)
		PHA03247	<422..938	CDD:223021	129/662 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..494		7/42 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..707		52/260 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	722..1026		70/351 (20%)
		PRK07764	<735..940	CDD:236090	49/245 (20%)
		PRK12678	846..>1113	CDD:237171	54/277 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1085..1131		6/16 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1149..1254
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1275..1294