Protein Alignment Usp32 and USP11

DIOPT Version :9

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001358001.1
• Gene: USP11 / 8237
• HGNCID: 12609
• Length: 920
• Species: Homo sapiens
• Alignment Length: 1392
• Identity: 327/1392 - (23%)
• Similarity: 475/1392 - (34%)
• Gaps: 564/1392 - (40%)

  Fly   374 GLWPQCKHMENDIVRGWLRREERRPYRVGQFWYLITHDWWLSWMQYTQHTTHTCDYCKRTASQRT 438
            ||..|.:.:||    |...||  ||.|.|:.|:|:...|:..|..|.|
Human    34 GLDSQWRQIEN----GESGRE--RPLRAGESWFLVEKHWYKQWEAYVQ----------------- 75

  Fly   439 AVDEALVCDESFNTHSLEQHDSYSLGSGTGSASGSGSASSGISAGRHCGPVRPGPIDNSNLITAN 503
                                             |....||..          ||.|:|:.|
Human    76 ---------------------------------GGDQDSSTF----------PGCINNATL---- 93

  Fly   504 PFRN-VRTLTGEGGHLKRDTPLVQNHDFELVPKSLWKALNRWYG---DNLPLPRQVIQPPNSDVE 564
             |:: :.....||        ||:..|:.|:|.:.|..|..|||   ...|:.|:||:.||.. :
Human    94 -FQDEINWRLKEG--------LVEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIELPNIQ-K 148

  Fly   565 LELYPLNLRILLHQAQPSQTGVGGGTQLGSWGSTVSGGYGVLASGGGYAAIAVSSVLQPPKRYLA 629
            :|:||:.|.::.|            ..||.                                  :
Human   149 VEVYPVELLLVRH------------NDLGK----------------------------------S 167

  Fly   630 YTAAFSR-------LATVRQVGEFLCEQLRLKSEDIRLWHVPQLDNGAI-LLEEDAMCLKELLIR 686
            :|..||.       |.|.|:  .||.|    ..||.|||  .:...|:: .|.:..:.:.:..:.
Human   168 HTVQFSHTDSIGLVLRTARE--RFLVE----PQEDTRLW--AKNSEGSLDRLYDTHITVLDAALE 224

  Fly   687 DNDQLLLEIRNKDLTWPE-ELGSLATAQCGQGAGTPGDRRRLTRSSIMSVHAPGATGLHNLGNTC 750
            ....:::|.|.||.|||. :|..:......:.....|.              ||..||.||||||
Human   225 TGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQ--------------PGICGLTNLGNTC 275

  Fly   751 FMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWTATTRSVAPLKLR 815
            |||:|||.|.|...|.:||....:..|:|..|.||.||::|..||:|:|:.|:...||:.|...:
Human   276 FMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFK 340

  Fly   816 FCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHA 880
            ..|..:|.||.|..||||||||.:|||.||||||||.:|.|.||.|:.||||:.||.|||..|..
Human   341 NKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKR 405

  Fly   881 RNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILLD-GSVPIKYG 944
            ||.|:|:|.|:|..||.:.|..||:.||.||||..||:|||:.:....||..|.:| ...|.::.
Human   406 RNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHR 470

  Fly   945 FRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLRT-QSAKELYVYQLPEQS 1008
            ..:....|.|.|...||....:.|..|:|.::::.:..::...:|.|.: ....:::||::
Human   471 LVVPKKGKISDLCVALSKHTGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEV---- 531

  Fly  1009 MRTRSNSGLSMHIEQGLKDI-------QRSSALITSAQDSLSSLSTLQTSSHRASSRVLCNGHVS 1066
                  ||....||...:||       :|     |.|:|                    .|....
Human   532 ------SGRIEAIEGSREDIVVPVYLRER-----TPARD--------------------YNNSYY 565

  Fly  1067 GLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCFGKRECMPHSL 1131
            ||.:.|                                  |.||      ||        :|...
Human   566 GLMLFG----------------------------------HPLL------VS--------VPRDR 582

  Fly  1132 FCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSMESSLTEPIPLA 1196
            |.: |.|.      |..|:       |:|
Human   583 FTW-EGLY------NVLMY-------RLS------------------------------------ 597

  Fly  1197 DLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTSQPET 1261
                            .|.|.||..               ||  ::|:.::.|:.|:.....|.|
Human   598 ----------------RYVTKPNSD---------------DE--DDGDEKEDDEEDKDDVPGPST 629

  Fly  1262 SSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPNSEGGTHKDLYCA 1326
            ..   |.|..: |.:||......:|                     .|.|:.|..|.:.
Human   630 GG---SLRDPE-PEQAGPSSGVTNR---------------------CPFLLDNCLGTSQ------ 663

  Fly  1327 VWLQVSRLLSPLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNN 1391
             |        |.....:|.               |||:.|.::|
Human   664 -W--------PPRRRRKQL---------------FTLQTVNSNG--------------------- 683

  Fly  1392 DYVLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTTKYFEDFTIAIDWDP 1456
                          .|:.:|                 :||...:..|           |||||:|
Human   684 --------------TSDRTT-----------------SPEEVHAQPY-----------IAIDWEP 706

  Fly  1457 TALHLRYQSTLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEEKLEQ---WYHCSHCKGKKPA 1518
            ......|.......:|.|:.:....::  .||.|..|:..||:.|.||:   || |..||..:.|
Human   707 EMKKRYYDEVEAEGYVKHDCVGYVMKK--APVRLQECIELFTTVETLEKENPWY-CPSCKQHQLA 768

  Fly  1519 TKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPYLASVPQETILRHKELLELK 1583
            ||||.:|.||.|||:|||||:.......|...:|.||..|.|.:.::..
Human   769 TKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVIQ---------------- 817

  Fly  1584 NDAEMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTKATASPPPTGNILRQSKTKNAVRRQRLI 1648
                                 |..|...||
Human   818 ---------------------PQNESNPEL----------------------------------- 826

  Fly  1649 STSLTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYAVVSHSGMLNGGHYISYASNA-TGSWYCY 1712
                            |              :|.|.||.:|.|.:..|||.::|.|. :|.|:.:
Human   827 ----------------Y--------------KYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYF 861

  Fly  1713 NDSSCREISQKPVIDPSAAYLLFYERK 1739
            :|:|...:::.. |:..|||:|||:|:
Human   862 DDNSVSPVNENQ-IESKAAYVLFYQRQ 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	170/530 (32%)
		Peptidase_C19	<1480..1737	CDD:351799	62/260 (24%)
USP11	NP_001358001.1	UBP12	56..886	CDD:227847	315/1361 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920