DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and Usp45

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_690038.1	Gene:	Usp45 / 77593	MGIID:	101850	Length:	813	Species:	Mus musculus

Alignment Length:	705	Identity:	156/705 - (22%)
Similarity:	244/705 - (34%)	Gaps:	198/705 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   738 PGATGLHNLGNTCFMNAALQVLFNTQ---PLAQYFQREMHRFEVNAAN---------KLGTKGQL 790
            |...|:.|||||||.||.:|.|..|.   .|....:.:..:|:::.::         :|.:.|.|
Mouse   188 PSVKGITNLGNTCFFNAVIQNLAQTYILFELMNEIKEDGTKFKISLSSAPQLEPLVVELSSPGPL 252

  Fly   791 AMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALH-EDLNRVMEK 854
            .......|..:..|....::|..|...:.:.||:|.|..|.||||||..||||:. |:..|:..
Mouse   253 TSALFLFLHSMKEAEKGPLSPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTEETKRIQA- 316

  Fly   855 PYSELKDSNGRPDKIVAAEAWSQHHARNQ-----SIIIDLFYGQLKSKVSCLGCGHESVRFDPFS 914
              |.||..|....|....|...:..|..:     :.|..:|.|:|.|.|.|..|.:.|...|||.
Mouse   317 --SILKAFNNPTTKTADDETRKKVKAYGKEGVKMNFIDRIFIGELTSTVMCEECANISTMKDPFI 379

  Fly   915 LLSLPLPVENYIYFEVLVILLD--------------GSVPIKYGFRLNSDCKYSHLKHKLSTMCS 965
            .:|||: :|..:...||:..:.              |:|.:....:..:..|:|....|
Mouse   380 DISLPI-IEERVSKPVLLGKMSKCRSLQETDQDHNKGTVTVGNAHQPRASRKHSSPNDK------ 437

  Fly   966 LPPNLMLVCELWNSQIRQVLNDDEKLRTQSAKELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQR 1030
                            .|:.:|.:.||...::|       |:::.|...:
Mouse   438 ----------------NQLSHDRKHLRKWPSEE-------EKTVVTHPKN--------------- 464

  Fly  1031 SSALITSAQDSLSSLSTLQTSSHRAS-SRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVS 1094
                     |:|.:.....|.|..|| :..|.:|......:|...:..::.|:....|. .|::.
Mouse   465 ---------DNLEASPPASTLSTEASLNESLTDGSERDASLESSVDADSEASEPEIASK-QPVLL 519

  Fly  1095 TYSGNGSGDNQVHELLP--DEAGKVSRCFGKRECMPHSLFCFKESLILSSS-------------- 1143
            ...|:..|..:.|..||  .|..:.....|..|.|..::    ..|.||.:
Mouse   520 RSRGDSCGHAEQHPHLPLASELPQAKETHGGEEEMAEAI----AELHLSGTVTGNRDFHREKQPL 580

  Fly  1144 --PEN-TFMHGAAAQQKRVSSAKLLHTESN---TSSMSYTNHSGENSMESSLTEPIPLADLEPVS 1202
              |.| .|..|...:         ||:..|   |.|.||...|.|.|::|.|.:   ...:|.:.
Mouse   581 NVPNNLCFSEGKHTR---------LHSAQNAFQTLSQSYVTTSKECSVQSCLYQ---FTSMELLM 633

  Fly  1203 SRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTSQPETSSGVYS 1267
            ..|....|||:                            |...:.|.:    |:|..:.:.|||:
Mouse   634 GNNKLLCEDCT----------------------------EKRRKCHKE----TSSAEKKAGGVYT 666

  Fly  1268 RRSSQ------PP---------HKAGKYLVAVHRKITRHDSYFLSY----------------HKT 1301
            ....|      |.         |:||..|    ||:.||..:.|:.                .|.
Mouse   667 NARKQLLISAVPAILILHLKRFHQAGLSL----RKVNRHVDFPLTLDLAPFCAATCKNISVGEKV 727

  Fly  1302 RPSLFGVPLLIPNSEGGTHKDLYCAVWLQVSRLLSPLPATTEQANHAADCDDSLG 1356
            ...|:|:.....:..|| |...|..|.:. ||.||......:.|....:.|..||
Mouse   728 LYGLYGIVEHSGSMRGG-HYTAYVKVRVP-SRKLSECITGRKTAAGLKEPDGELG 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	75/295 (25%)
		Peptidase_C19	<1480..1737	CDD:351799
Usp45	NP_690038.1	Interaction with ERCC1. /evidence=ECO:0000305\|PubMed:25538220	1..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		UBP14	<72..>359	CDD:227532	50/173 (29%)
		Peptidase_C19	192..>388	CDD:351799	61/199 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..552		31/200 (16%)
		Peptidase_C19K	<587..810	CDD:239132	53/244 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910