DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and Usp20

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_083122.1	Gene:	Usp20 / 74270	MGIID:	1921520	Length:	916	Species:	Mus musculus

Alignment Length:	1038	Identity:	182/1038 - (17%)
Similarity:	257/1038 - (24%)	Gaps:	532/1038 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly   739 GATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWT 803
            |.||:.||||:|:||||||.|.|..||.|:|      .|.....:...|..|...|.:|:.|||.
Mouse   143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFF------LECGGLVRTDKKPALCKSYQKLISEVWH 201

  Fly   804 ATTRS-VAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPD 867
            ....| |.|..|...:....|.|.|..|.|:||.|..|:|.|||:|...|
Mouse   202 KKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPM--------------- 251

  Fly   868 KIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLV 932
              |||
Mouse   252 --VAA------------------------------------------------------------ 254

  Fly   933 ILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLRTQSAK 997

Mouse   255 ----------------------------------------------------------------- 254

  Fly   998 ELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCN 1062
                                              .|.:|.|:||.||.:..:....|:.|.
Mouse   255 ----------------------------------VAALTDARDSDSSDTDERRDGDRSPSE---- 281

  Fly  1063 GHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCFGKRECM 1127
                           .:...|:|:|:.........|.||...::..|:.||||:
Mouse   282 ---------------DEFLSCDSSSDRGEGDGQGRGGGSSKAEMELLISDEAGR----------- 320

  Fly  1128 PHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSMESSLTEP 1192
                                    |.::::|:...|....:..|:|
Mouse   321 ------------------------AISEKERMKDRKFSWGQQRTNS------------------- 342

  Fly  1193 IPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTS 1257
                  |.|.       ||....|               |...:|||:.|.     ..|...:||
Mouse   343 ------EQVD-------EDADVDT---------------AMASLDEQSREA-----QPPSPRSTS 374

  Fly  1258 ---QPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLL-----IPN 1314
               .||..:..:.|.||:|       ...||.....|.....|..:..|...|...:     :|:
Mouse   375 PCQTPEPDNEAHIRSSSRP-------CSPVHHHHEGHSKLSSSPPRASPVRMGPSYVLKKAQVPS 432

  Fly  1315 SEGGTHKD------------------LYCAVWLQVSR-------LLSPLPATTEQAN-HAADCDD 1353
            :.|...|:                  :.|....:||.       |..|:|...:.|. |:|
Mouse   433 TGGRRRKEQSYRSVISDVFNGSVLSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSA---- 493

  Fly  1354 SLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKF 1418
             :..:.|....|                       |.:.|..||.|..|
Mouse   494 -IYQNVPAKPGA-----------------------CGDSYSSQGWLAFI---------------- 518

  Fly  1419 PSLPNLEAKRTPEYTASLSYTPTTKYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRRE 1483
                       .||......:.|..:|        |.|.
Mouse   519 -----------VEYIRRFVVSCTPSWF--------WGPV-------------------------- 538

  Fly  1484 QVEPVDLNHCLRAFTSEEKL--EQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKWV 1546
                |.|..||.||.:.::|  :..|.|..||..:...|..::..||.||.||||||........
Mouse   539 ----VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLCLPEILCVHLKRFRHEVMYSF 599

  Fly  1547 KSQKVVHFPFDDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKE 1611
            |....|.||.:..|..|:||          ||            .|::|.:
Mouse   600 KVSSHVSFPLEGLDLRPFLA----------KE------------CTSQVTT-------------- 628

  Fly  1612 ELPNQTGSTKATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQ 1676

Mouse   629 ----------------------------------------------------------------- 628

  Fly  1677 FDPRYRLYAVVSHSGMLNGGHYISYASNA-TGSWYCYNDSSCREISQKPVIDPSAAYLLFYER 1738
                |.|.:|:.|.|....||||:|..|. .|.||.::|....|: .:.|:....||:|||.:
Mouse   629 ----YDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEV-HETVVQNVEAYVLFYRK 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	50/263 (19%)
		Peptidase_C19	<1480..1737	CDD:351799	55/259 (21%)
Usp20	NP_083122.1	zf-UBP	30..90	CDD:366940
		UBP12	<73..688	CDD:227847	182/1038 (18%)
		UCH	145..684	CDD:366104	179/1032 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..420		48/274 (18%)
		DUSP	704..787	CDD:197831
		DUSP	812..896	CDD:197831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910