DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp32 and USP4

DIOPT Version :10

Sequence 1:NP_001262074.2 Gene:Usp32 / 40169 FlyBaseID:FBgn0036913 Length:1779 Species:Drosophila melanogaster
Sequence 2:NP_003354.2 Gene:USP4 / 7375 HGNCID:12627 Length:963 Species:Homo sapiens


Alignment Length:1473 Identity:331/1473 - (22%)
Similarity:495/1473 - (33%) Gaps:615/1473 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   386 IVRGWLRREERRPYRVGQFWYLITHDWWLSWMQYTQHTTHTCDYCKRTASQRTAVDEALVCDESF 450
            ::|..|:|        |..||||...|:..|.:|                         |..:|:
Human    23 LMRTTLQR--------GAQWYLIDSRWFKQWKKY-------------------------VGFDSW 54

  Fly   451 NTHSLEQHDSYSLGSGTGSASGSGSASSGISAGRHCGPVRPGPIDNSNLITANPFRNVRTLTGEG 515
            :.:::.:|:.:                             |||||||.|. ::|         |.
Human    55 DMYNVGEHNLF-----------------------------PGPIDNSGLF-SDP---------ES 80

  Fly   516 GHLKRDTPLVQNHDFELVPKSLWKALNRWYG---DNLPLPRQVIQPP--NSDVELELYPLNLRIL 575
            ..||..  |:...|:.|||...|..|..|||   ...|:.|:|::..  ....::|:|.|.|: |
Human    81 QTLKEH--LIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELK-L 142

  Fly   576 LHQAQPSQTGVGGGTQLGSWGSTVSGGYGVLASGGGYAAIAVSSVLQPPKRYLAYTAAFSRLATV 640
            ...:.|                                    ::||         :..||:..|:
Human   143 CENSDP------------------------------------TNVL---------SCHFSKADTI 162

  Fly   641 RQVGEFLCEQLRLKSE-DIRLWH---------VPQLDNGAILLEEDAMCLKELLIRDNDQLLLEI 695
            ..:.:.:.:...:.:| :.|||:         :.:|||          .:::..:.....|::|.
Human   163 ATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDN----------TVQDAGLYQGQVLVIEP 217

  Fly   696 RNKDLTWPEEL----------------------------GSL-----ATAQCGQ-----GAGTPG 722
            :|:|.|||.:.                            .||     :|:.||.     ..|..|
Human   218 QNEDGTWPRQTLQSKSSTAPSRNFTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSG 282

  Fly   723 DRRRLTRSSIMSVH-APGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGT 786
            ...........|.| .||..||.|||||||||:|||.|.||.||..||.::.:..|:|..|.||.
Human   283 FSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGM 347

  Fly   787 KGQLAMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRV 851
            ||::|..||||:|::|:.....|||...:..|.::||||:|..|.||||||.:|||.||||||||
Human   348 KGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRV 412

  Fly   852 MEKPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLL 916
            .:|||.||||:|||||.:||.|||..|..||.|:|:|.|:|..||.:.|..|...||.||||..|
Human   413 KKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477

  Fly   917 SLPLPVENYIYFEVLVILLDGSV-PIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQ 980
            :||||::.....||.::..|... |.:|...:......|.|...||.:..:....|:|.:::|.:
Human   478 TLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHR 542

  Fly   981 IRQVLNDDEKL-RTQSAKELYVYQLPEQSMRTRSNSGLSMHI-EQGLKDIQRSSALITSAQDSLS 1043
            ..::...||.| ......:::||::...|:.......|.::. |:..:....|||.....|..| 
Human   543 FHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLL- 606

  Fly  1044 SLSTLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHE 1108
                |....|:.:...|..                  :.|:..|.|                |.:
Human   607 ----LSVPKHKLTLESLYQ------------------AVCDRISRY----------------VKQ 633

  Fly  1109 LLPDEAGKVSRCFGKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSS 1173
            .||||.|                          |||                             
Human   634 PLPDEFG--------------------------SSP----------------------------- 643

  Fly  1174 MSYTNHSGENSMESSLTEPIPLADLEPVS---SRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLD 1235
                                    |||.:   |||...|||                     ..:
Human   644 ------------------------LEPGACNGSRNSCEGED---------------------EEE 663

  Fly  1236 VDEQAE--------EGNAEDHDQPDQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHD 1292
            ::.|.|        ||:.||....|...|:|                           :||    
Human   664 MEHQEEGKEQLSETEGSGEDEPGNDPSETTQ---------------------------KKI---- 697

  Fly  1293 SYFLSYHKTRPSLFGVPLLIPNSEGGTHKDLYCAVWLQVSRLLSPLPATTEQANHAADCDDSLGY 1357
                   |.:|                                               |...|  
Human   698 -------KGQP-----------------------------------------------CPKRL-- 706

  Fly  1358 DFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLP 1422
               ||...|.:.|..                            .||:.|::....|:|::     
Human   707 ---FTFSLVNSYGTA----------------------------DINSLAADGKLLKLNSR----- 735

  Fly  1423 NLEAKRTPEYTASLSYTPTTKYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEP 1487
                                     .|:|:|||.....|.|.......:..|.::...::::...
Human   736 -------------------------STLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTT 775

  Fly  1488 VDLNHCLRAFTSEEKL---EQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKW-VKS 1548
            |.|..|:..||:.|.|   :.|| |.:||..:.||||..:|.||.||:||||||: .|..| .|.
Human   776 VALRDCIELFTTMETLGEHDPWY-CPNCKKHQQATKKFDLWSLPKILVVHLKRFS-YNRYWRDKL 838

  Fly  1549 QKVVHFPFDDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEEL 1613
            ..||.||....:.:.::.                                               
Human   839 DTVVEFPIRGLNMSEFVC----------------------------------------------- 856

  Fly  1614 PNQTGSTKATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQFD 1678
                                                 :|:..|.|                    
Human   857 -------------------------------------NLSARPYV-------------------- 864

  Fly  1679 PRYRLYAVVSHSGMLNGGHYISYASN-ATGSWYCYNDSSCREISQKPVIDPSAAYLLFYERKGLD 1742
              |.|.||.:|.|.:..|||.:||.| ..|.||.::||:....|:..:: ..|||:|||:|:  |
Human   865 --YDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIV-TKAAYVLFYQRR--D 924

  Fly  1743 YEPY-LPNI------EGRTLPNTASVPLEVDETEGELKKLCSI 1778
            .|.| .|::      :|.|.|:::......||.       ||:
Human   925 DEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEA-------CSM 960

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp32NP_001262074.2 EFh_PI-PLC 198..>251 CDD:333715
EF-hand motif 198..222 CDD:320029
EF-hand_7 227..290 CDD:463900
UBP12 486..>1002 CDD:227847 178/571 (31%)
Peptidase_C19 <1480..1737 CDD:470612 60/261 (23%)
USP4NP_003354.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
Necessary for interaction with SART3. /evidence=ECO:0000269|PubMed:20595234 27..216 57/318 (18%)
UBP12 35..923 CDD:227847 314/1405 (22%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:P35123 133..141 3/7 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..253 5/33 (15%)
Required for USP4 activation by providing conformational flexibility between the DUSP and catalytic domains. /evidence=ECO:0000269|PubMed:25404403 229..295 7/65 (11%)
Regulates ubiquitin dissociation. /evidence=ECO:0000269|PubMed:25404403 384..386 1/1 (100%)
Necessary for interaction with RBL2. /evidence=ECO:0000250|UniProtKB:P35123 405..407 1/1 (100%)
Necessary for interaction with RB1 and RBL2. /evidence=ECO:0000250|UniProtKB:P35123, ECO:0000269|PubMed:11571652 459..463 1/3 (33%)
Interacts with DUSP and ubiquitin-like 1 domains and is required for USP4 activation. /evidence=ECO:0000269|PubMed:25404403 485..775 81/576 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..699 26/199 (13%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P35123 767..772 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 928..963 9/40 (23%)
Blue background indicates that the domain is not in the aligned region.

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