Protein Alignment Usp32 and USP17L29

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001229261.1
• Gene: USP17L29 / 728405
• HGNCID: 44457
• Length: 530
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 125/611 - (20%)
• Similarity: 187/611 - (30%)
• Gaps: 258/611 - (42%)

  Fly  1187 SSLTEPIPLA---------DLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGH--TLGASLDVDEQA 1240
            :||.|..||:         ||.||:.           :.:|.:...||:..  .:||.|.
Human    35 TSLPEKSPLSCETRVDLCDDLAPVAR-----------QLAPREKLPLSSRRPAAVGAGLQ----- 83

  Fly  1241 EEGNAEDHDQPDQITTSQPETSSGVYSRRSSQPPHK-AGKYLVAVHRKITR--HDSYFLSYHKTR 1302
            ..||....:...|..|..|..::.:.||..||..|: .|..|..:...|||  |:    ..|..:
Human    84 NMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHN----PGHVIQ 144

  Fly  1303 PSLFGVPLLIPNSEGGTHKDLYCAVWLQVSRLLSP-LPATTEQANHAADCDDSL------GYDFP 1360
            ||    ..|......|..:|.:..:...|..:... ||...:..:|:.  |.:|      ||
Human   145 PS----QALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSK--DTTLIHQIFGGY--- 200

  Fly  1361 FTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNLE 1425
                             |.|     :|:|.:.:           ..|:|..|.::
Human   201 -----------------WRS-----QIKCLHCH-----------GISDTFDPYLD---------- 222

  Fly  1426 AKRTPEYTASLSYTPTTKYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEPVDL 1490
                                    ||:|.....   ..|..||:|              |:|.:|
Human   223 ------------------------IALDIQAAQ---SVQQALEQL--------------VKPEEL 246

  Fly  1491 NHCLRAFTSEEKLEQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKVVHFP 1555
            |.           |..|||..|..:.||:|.|.:.....:||:.||||:.|.|.  |..|.|.:|
Human   247 NG-----------ENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGN--KIAKNVQYP 298

  Fly  1556 FDDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEELPNQTGST 1620
             :..|..||:
Human   299 -ECLDMQPYM------------------------------------------------------- 307

  Fly  1621 KATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYA 1685
                |.|.||                         |:|                      |.|||
Human   308 ----SQPNTG-------------------------PLV----------------------YVLYA 321

  Fly  1686 VVSHSG-MLNGGHYISYASNATGSWYCYNDSSCREISQKPVIDPSAAYLLFYERKGLDYEPYLPN 1749
            |:.|:| ..:.|||.||.....|.||..:|:.....|...|:. ..||:|||.:|. ::|.:..:
Human   322 VLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLS-QQAYVLFYIQKS-EWERHSES 384

  Fly  1750 I-EGRTLPNTASVPLEVDETEGELKK 1774
            : .||......:...:...|:||||:
Human   385 VSRGREPRALGAEDTDRRATQGELKR 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847
		Peptidase_C19	<1480..1737	CDD:470612	56/257 (22%)
USP17L29	NP_001229261.1	Peptidase_C19E	79..373	CDD:239126	103/516 (20%)
		HABP4_PAI-RBP1	<417..454	CDD:461421