DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp32 and USP37

DIOPT Version :10

Sequence 1:NP_001262074.2 Gene:Usp32 / 40169 FlyBaseID:FBgn0036913 Length:1779 Species:Drosophila melanogaster
Sequence 2:NP_065986.3 Gene:USP37 / 57695 HGNCID:20063 Length:979 Species:Homo sapiens


Alignment Length:1382 Identity:257/1382 - (18%)
Similarity:413/1382 - (29%) Gaps:582/1382 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   431 KRTASQRTAVDEALVCDESFNTHSLEQHDSYS----LGS-GTGS---ASGSGSASSGISAGRHCG 487
            |.|:.|.:..|.    ..|....|||..|...    ||: |.||   .:|||.|.:..|......
Human   131 KETSRQLSYSDN----QASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIARTIPSLTSTST 191

  Fly   488 PVRPGPIDNSNLITANPFRNVRTLTGEGGHLKRDTPLVQNHDFELVPKSLWKALNRWYGDNLPLP 552
            |:|.|.::|.   |....|.:.|    |..|..|.|  :.:|.....|::.....::.       
Human   192 PLRSGLLENR---TEKRKRMIST----GSELNEDYP--KENDSSSNNKAMTDPSRKYL------- 240

  Fly   553 RQVIQPPNSDVELELYPLNLRILLHQAQPSQTGVGGGTQLGSWGSTVSGGYGVLASGGGYAAIAV 617
                   .|..|.:|       .|.|::.::|......|..|:..:.:|.....:.|.......|
Human   241 -------TSSREKQL-------SLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNV 291

  Fly   618 SSVLQPPKRYLAYTAAFSRLATVRQVGEFLCEQLRLKSEDIRLWHVPQLDNGAILLEEDAMCLKE 682
            ||.....||.|.                ||.:.:.|..:.:|                   |   
Human   292 SSQTPSAKRSLG----------------FLPQPVPLSVKKLR-------------------C--- 318

  Fly   683 LLIRDNDQLLLEIRNKDLT-WPEELGSLATAQCGQGAGTPGDRRRLTRSSIMSVHAPGATGLHNL 746
                          |:|.| |.:....|::.|..|                       ..|..||
Human   319 --------------NQDYTGWNKPRVPLSSHQQQQ-----------------------LQGFSNL 346

  Fly   747 GNTCFMNAALQVLFNTQPLAQYFQRE---MHRFEVNAANKLGTKGQLAMRYAELL--KEVWTATT 806
            ||||:|||.||.||:.|..|....::   ..:..:||         |..|:|.||  |::..:.|
Human   347 GNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNA---------LIRRFAHLLVKKDICNSET 402

  Fly   807 RSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVME----KPYSELKDSNGRPD 867
            :.....|::..::..|.:|:|..|:|:.|.|...||.|.||:.::.:    :|.|..::|   ||
Human   403 KKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENS---PD 464

  Fly   868 KIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSL-------PLPVENY 925
             |.|..|::      ..:|.:|.: :::..:.|..||....:.:.|:.||:       |||..: 
Human   465 -ISATRAYT------CPVITNLEF-EVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRS- 520

  Fly   926 IYFEVLVILLDGSVPIKY-GFRLNSDC-----KYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQV 984
                     :..|:.:.: ...|...|     |.:.::||.:   .||..|:|..:.::..:...
Human   521 ---------IQDSLDLFFRAEELEYSCEKCGGKCALVRHKFN---RLPRVLILHLKRYSFNVALS 573

  Fly   985 LNDDEKLRTQSAKELYVYQLPEQSMRTRS--NSGLSMH--IEQGLKDIQRSSALITSAQDSLSSL 1045
            ||:  |:..|.....|:......:..|:.  ..|.|.|  |.:.||..|..::.|||     .|.
Human   574 LNN--KIGQQVIIPRYLTLSSHCTENTKPPFTLGWSAHMAISRPLKASQMVNSCITS-----PST 631

  Fly  1046 STLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELL 1110
            .:.:.:....||..||      ||.:.|.|:                                  
Human   632 PSKKFTFKSKSSLALC------LDSDSEDEL---------------------------------- 656

  Fly  1111 PDEAGKVSRCFGKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRV-SSAKLLHTESNTSSM 1174
                 |.|....:|.|.                     |.|...||:.: ..:||...|.:.|.:
Human   657 -----KRSVALSQRLCE---------------------MLGNEQQQEDLEKDSKLCPIEPDKSEL 695

  Fly  1175 SYTNHSGENSMESSLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQ 1239
                   |||....::|...||.:..:|.|:.|  ...|:......:|...||.   |..|:.|.
Human   696 -------ENSGFDRMSEEELLAAVLEISKRDAS--PSLSHEDDDKPTSSPDTGF---AEDDIQEM 748

  Fly  1240 AEEGNAEDHDQPDQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPS 1304
            .|        .||.:.|.:|:|                          ||..|          |:
Human   749 PE--------NPDTMETEKPKT--------------------------ITELD----------PA 769

  Fly  1305 LFGVPLLIPNSEGGTHKDLYCAVWLQVSRLLSPLPATTEQANHAADCDDSLGYDFPFTLRAVKAD 1369
            .|                                   ||...   |||::               
Human   770 SF-----------------------------------TEITK---DCDEN--------------- 781

  Fly  1370 GLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTA 1434
                                                                   :..:|||.:.
Human   782 -------------------------------------------------------KENKTPEGSQ 791

  Fly  1435 SLSYTPTTKYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEPVDLNHCLRAFTS 1499
            .               .:||       ..|..:||           .||                
Human   792 G---------------EVDW-------LQQYDMER-----------ERE---------------- 807

  Fly  1500 EEKLEQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPY 1564
            |::|:|                                                           
Human   808 EQELQQ----------------------------------------------------------- 813

  Fly  1565 LASVPQETILRHKELLELKNDAEMTMATNEVVSELDE--IDAPSKEVKEELPNQTGSTKATASPP 1627
              ::.|.  |:.:|..|.|.|.::..||...:.|.:.  :|                  |..|..
Human   814 --ALAQS--LQEQEAWEQKEDDDLKRATELSLQEFNNSFVD------------------ALGSDE 856

  Fly  1628 PTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVD--QFDPRYRLYAVVSHS 1690
            .:||                       ..:.|.|:.:.....||.:.:  .....|||.:||||.
Human   857 DSGN-----------------------EDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHI 898

  Fly  1691 GML-NGGHYISYASN-ATGSWYCYNDSSCREISQKPVID--PSAAYLLFYERKGLDYEPYLPNIE 1751
            |.. :.|||||...: ...:|:.|||....:|.:..|..  ..:.|:.||..|.: ::..|    
Human   899 GSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEI-FDELL---- 958

  Fly  1752 GRTLPNTASVPLEVDET 1768
             .|..|:.|:..||.:|
Human   959 -ETEKNSQSLSTEVGKT 974

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp32NP_001262074.2 EFh_PI-PLC 198..>251 CDD:333715
EF-hand motif 198..222 CDD:320029
EF-hand_7 227..290 CDD:463900
UBP12 486..>1002 CDD:227847 113/538 (21%)
Peptidase_C19 <1480..1737 CDD:470612 44/264 (17%)
USP37NP_065986.3 UCH_N 3..105 CDD:465227
KEN box 1 32..34
D-box 1 71..79
D-box 2 96..105
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..153 7/25 (28%)
D-box 3 160..168 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..304 30/166 (18%)
KEN box 2 221..223 0/1 (0%)
UCH 342..607 CDD:425685 74/299 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..701 9/34 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 719..795 27/247 (11%)
KEN box 3 782..784 0/1 (0%)
Peptidase_C19 <881..949 CDD:239072 21/67 (31%)
Blue background indicates that the domain is not in the aligned region.

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