Protein Alignment Usp32 and USP36

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001372098.1
• Gene: USP36 / 57602
• HGNCID: 20062
• Length: 1124
• Species: Homo sapiens
• Alignment Length: 1138
• Identity: 227/1138 - (19%)
• Similarity: 385/1138 - (33%)
• Gaps: 323/1138 - (28%)

  Fly   714 CGQGAGT------PGDRRRLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQRE 772
            ||.|...      |.:|..|....:..|.|    ||||||||||:||.:|.|..|.|||.|...:
Human    93 CGDGVPAPQKVLFPTERLSLRWERVFRVGA----GLHNLGNTCFLNATIQCLTYTPPLANYLLSK 153

  Fly   773 MHRFEVNAANKLGTKGQLAMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELL 837
            .|....:.    |:...|.:....:: :.:..:..::.|:.....:.|.|..|..|.|.|:.|.|
Human   154 EHARSCHQ----GSFCMLCVMQNHIV-QAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFL 213

  Fly   838 EWLLDALHEDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLG 902
            .:.:||:.:..             .||      .|:...|..|  .:::..:|.|.|:|:|.|..
Human   214 RYTIDAMQKAC-------------LNG------CAKLDRQTQA--TTLVHQIFGGYLRSRVKCSV 257

  Fly   903 CGHESVRFDPFSLLSLPL--------PVENYIYFEVLVILLDG-----------SVPIKYGFRLN 948
            |...|..:||:..::|.:        .:|.::..:|    |.|           .||....|.:
Human   258 CKSVSDTYDPYLDVALEIRQAANIVRALELFVKADV----LSGENAYMCAKCKKKVPASKRFTI- 317

  Fly   949 SDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLR-----TQSAKELYVYQLPEQS 1008
                     |:.|.:.:|  :|.........:|.:.:...|.|.     :|:..:..:|.|
Human   318 ---------HRTSNVLTL--SLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGL---- 367

  Fly  1009 MRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCN----------- 1062
            .....:||.|.|.......::.|:.......|||         .|.::.:|:.|
Human   368 YAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSL---------VHSSNVKVVLNQQAYVLFYLRI 423

  Fly  1063 --------GHVS---GLDVEGEAEVGTDVSQCNSNSNYNPIVST-------YSGNGSGDNQVHEL 1109
                    |.:|   ...:.|...|..|.|:.|..   |.|:|:       .||.....:...|:
Human   424 PGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIG---NGIISSPLTGKRQDSGTMKKPHTTEEI 485

  Fly  1110 -LP-DEAGKVSRCFGKRECMPHSLFCFKESLILSSSPEN--TFMHGAAAQQKRVSSAK------- 1163
             :| ...|.......:..|:|..|.....|..||.:|.:  |.:.....:.|:.:..:
Human   486 GVPISRNGSTLGLKSQNGCIPPKLPSGSPSPKLSQTPTHMPTILDDPGKKVKKPAPPQHFSPRTA 550

  Fly  1164 --LLHTESNTSSMSYTNHSGE-NSMESSL-TEPIPLADLEPVSSRNGSG--GEDCSYRTSPNDSS 1222
              |..|.::.||.|.:...|. :|.:..| |.|..||    .::.||.|  |.|.|.......||
Human   551 QGLPGTSNSNSSRSGSQRQGSWDSRDVVLSTSPKLLA----TATANGHGLKGNDESAGLDRRGSS 611

  Fly  1223 GLSTGHTL-------------GASLDVDEQAEEGNAEDHDQ--PDQITTSQPETSSGVYSRRSSQ 1272
            ..|..|:.             ||:...|.|....:...|.:  |....:...:..|.|.|..:::
Human   612 SSSPEHSASSDSTKAPQTPRSGAAHLCDSQETNCSTAGHSKTPPSGADSKTVKLKSPVLSNTTTE 676

  Fly  1273 P-----PHKAGKYLVAVHR-----KITRHDSYFLSYHKTRPSLFGVPLLIPNSE----GGTHKDL 1323
            |     |..|.|..::..:     :.|.:|        .||     |...|:|:    ..|...:
Human   677 PASTMSPPPAKKLALSAKKASTLWRATGND--------LRP-----PPPSPSSDLTHPMKTSHPV 728

  Fly  1324 YCAVW-LQVSRLLSPLPATTEQANHAADCDDSLGYDFPF----TLRAVKADGLTCAICPWSSFCR 1383
            ..:.| :..:|.:||.|.::.:...            ||    ||       |:....|
Human   729 VASTWPVHRARAVSPAPQSSSRLQP------------PFSPHPTL-------LSSTPKP------ 768

  Fly  1384 GCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNL--EAKRTPEYTASLSYTPTTKYFE 1446
                        .|...|.:.::.:|:.|::|....|||:.  ||...|:       :|:.|..:
Human   769 ------------PGTSEPRSCSSISTALPQVNEDLVSLPHQLPEASEPPQ-------SPSEKRKK 814

  Fly  1447 DFTIAIDWDPTAL--------HLRYQSTLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEEKL 1503
            .|.    .:|..|        |:|     |.....|......::::.|....:......|..:..
Human   815 TFV----GEPQRLGSETRLPQHIR-----EATAAPHGKRKRKKKKRPEDTAASALQEGQTQRQPG 870

  Fly  1504 EQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCV-NGKWVKSQK----------------- 1550
            ...|. ...:.:.||.::.:....|.   |:.::..|| :|....|:|
Human   871 SPMYR-REGQAQLPAVRRQEDGTQPQ---VNGQQVGCVTDGHHASSRKRRRKGAEGLGEEGGLHQ 931

  Fly  1551 --VVH---FPFDDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAP-SKEV 1609
              :.|   .|..|.||.      ..|...|.|:..:.|.:      |...|.|...:..| |.:.
Human   932 DPLRHSSCSPMGDGDPE------AMEESPRKKKKKKRKQE------TQRAVEEDGHLKCPRSAKP 984

  Fly  1610 KEELPNQTGSTKATA-------------SPPPTGNILRQSKTKNAVRRQRLISTSLTK------- 1654
            ::.:..::.|...:|             :||.:.|..|:|...     |.|:..|..|
Human   985 QDAVVPESSSCAPSANGWCPGDRMGLSQAPPVSWNGERESDVV-----QELLKYSSDKAYGRKVL 1044

  Fly  1655 ------TPIVDGEFEDYHQHRLKPDVDQFDPRY 1681
                  :.:.....||..|.|.:..||.:|..:
Human  1045 TWDGKMSAVSQDAIEDSRQARTETVVDDWDEEF 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	72/317 (23%)
		Peptidase_C19	<1480..1737	CDD:470612	44/252 (17%)
USP36	NP_001372098.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..95		1/1 (100%)
		Peptidase_C19E	121..421	CDD:239126	78/358 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..577		31/149 (21%)
		PHA03247	<506..840	CDD:223021	81/403 (20%)