DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and usp16

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001139569.1	Gene:	usp16 / 569700	ZFINID:	ZDB-GENE-030131-4153	Length:	815	Species:	Danio rerio

Alignment Length:	1172	Identity:	214/1172 - (18%)
Similarity:	331/1172 - (28%)	Gaps:	542/1172 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   658 IRLWHVPQLDNGAILLEEDA------MCLKELLIRDND---QLLLEIRNKDLT-----------W 702
            |:.:..|:.:...::|..|.      :|..|:......   ||:..||.:.||           |
Zfish    93 IKHYETPRSEPHCLVLSLDVWSVWCYICDDEVQYSSTGQLAQLITNIRKQVLTAPDKRNASKKSW 157

  Fly   703 PEELGSLATAQCGQG--AGTPGDRRRLTR---------------SSIMSVHAPGATGLHNLGNTC 750
            .|::..:.:|:..|.  .|..|.::..::               |:::||.     ||.||||||
Zfish   158 KEDISVMNSAEQTQDEEKGKKGKQKSSSKQEDSPKSHQSAAAGSSAVVSVR-----GLSNLGNTC 217

  Fly   751 FMNAALQVLFNTQPLAQYFQR---EMHRFEVNAA---------NKLGTKGQLAMRYAELLKEVWT 803
            |.||.:|.|..||.|.:..::   |...|.:..|         .:|...|.|.:...:|:.|:..
Zfish   218 FFNAVVQSLSQTQYLRELLKQIAEEKSSFSITPALSSELDPLQIQLERPGSLTLAMCQLMNEIQE 282

  Fly   804 ATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALH-EDLNRV----MEKPYSELKDSN 863
            .....|.|.:|...|.|.||:|.|..|.||||||.:|||.:. |:..||    :|...|..|:..
Zfish   283 TKKGVVTPKELFTQVCKKAPRFKGFQQQDSQELLRYLLDGMRAEEAKRVNSGILEALKSSGKNFE 347

  Fly   864 GRPDKIVAAEAWSQHHARNQSIIID-LFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIY 927
            ....|.:..|.......:|   .:| :|.|.:.|.|.|..|...|:..:.|..||||:..|.|
Zfish   348 AEQTKKIVKEYEKDGAPKN---FVDRVFGGAMSSTVMCKECKTVSLVTEMFLDLSLPVADEAY-- 407

  Fly   928 FEVLVILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLR 992
                              |..:..|....:|.:|             :..:.....:.|.:|.:.
Zfish   408 ------------------RKKNQKKAVQHRHSVS-------------DDGDQDTSSLANGNEDMP 441

  Fly   993 TQSAKELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASS 1057
            |.:..:....:..:|:.:...|.          :..|:....:|     |.:: |.|:|:..|.|
Zfish   442 TGTGSKYQQKKAKKQAKKQAKNQ----------RRQQKQGGKVT-----LDAI-TNQSSTDPADS 490

  Fly  1058 RVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCFG 1122
            .:.                                ..|.|.|||.|.|
Zfish   491 SMQ--------------------------------TQTVSVNGSADAQ----------------- 506

  Fly  1123 KRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSMES 1187
                                 |.:|                      |...:|...|:.:...|
Zfish   507 ---------------------PADT----------------------NQEDLSLEKHNEDQDDE- 527

  Fly  1188 SLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPD 1252
               ||    :.|..:|.|             |..:.||...|      .::.||:.| ||.|:.:
Zfish   528 ---EP----EQEQAASVN-------------NRFTALSEDQT------TEDIAEQVN-EDEDEIE 565

  Fly  1253 QITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPNSEG 1317
            |
Zfish   566 Q---------------------------------------------------------------- 566

  Fly  1318 GTHKDLYCAVWLQVSRLLSPLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSFC 1382
                  .||...::...|:.:..||.......:.:|        ||..||
Zfish   567 ------NCAEEEELVEELNTMSLTTPSEGDVENGED--------TLEDVK--------------- 602

  Fly  1383 RGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTTKYFED 1447
                                                            |||
Zfish   603 ------------------------------------------------EYT-------------- 605

  Fly  1448 FTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEEKLEQ--WYHCS 1510
               .::.||   .|.:::...|      |..:.:...||     .||..||..|.|.:  ...|.
Zfish   606 ---VVNRDP---ELAFRALASR------TAPVKQECSVE-----SCLYQFTEVEHLTENNRLMCV 653

  Fly  1511 HCKGKKP-------------ATKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKVVHFPFDDFDPT 1562
            .|..::|             |.|::.|...|.:|.:|||||..|.....|..:.|.||
Zfish   654 TCTKQQPGYKDGCKKAVYRDALKQMLISDPPVVLTLHLKRFQQVAYSVCKVNRHVQFP------- 711

  Fly  1563 PYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTKATASPP 1627
                           ::|:|                     ||
Zfish   712 ---------------QILDL---------------------AP---------------------- 718

  Fly  1628 PTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYAVVSHSGM 1692
                                 ..||..|.:.:||.:               ..|.||.:|.|||.
Zfish   719 ---------------------FCSLNCTGVKEGETQ---------------VLYSLYGIVEHSGT 747

  Fly  1693 LNGGHYISY---------------------ASNATGSWYCYNDSSCREISQKPVIDPSAAYLLFY 1736
            :..|||.:|                     |..:.|||:..:|||...:.:..| ..|.||||||
Zfish   748 MRSGHYTAYVKSRPSTHNCVQNGTAAASGDAEASKGSWFHISDSSVHPVPEAKV-QSSQAYLLFY 811

  Fly  1737 ER 1738
            |:
Zfish   812 EK 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	95/398 (24%)
		Peptidase_C19	<1480..1737	CDD:351799	60/292 (21%)
usp16	NP_001139569.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		zf-UBP	68..124	CDD:307999	5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..200		6/51 (12%)
		Peptidase_C19	209..>406	CDD:321984	65/199 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..510		24/197 (12%)
		DnaJ	<482..>614	CDD:333066	48/412 (12%)
		Peptidase_C19K	<624..812	CDD:239132	60/294 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910