DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and usp11

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_002663119.3	Gene:	usp11 / 568334	ZFINID:	ZDB-GENE-081104-421	Length:	990	Species:	Danio rerio

Alignment Length:	1448	Identity:	353/1448 - (24%)
Similarity:	510/1448 - (35%)	Gaps:	527/1448 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 GLWPQCKHMENDIVRGWLRREERRPYRVGQFWYLITHDWWLSWMQYTQHTTHTCDYCKRTASQRT 438
            ||..|.:.::|      |.:::   .|.|..|||:...|:..|.:|..           |..|.:
Zfish    15 GLETQWREIDN------LNQQQ---LRAGDSWYLLDKRWYDQWKEYVD-----------TGDQNS 59

  Fly   439 AVDEALVCDESFNTHSLEQHDSYSLGSGTGSASGSGSASSGISAGRHCGPVRPGPIDNSNLI-TA 502
            .                    ||                             ||.|||:.|. ..
Zfish    60 T--------------------SY-----------------------------PGKIDNTELYEDL 75

  Fly   503 NPFRNVRTLTGEGGHLKRDTPLVQNHDFELVPKSLWKALNRWYG--DNL-PLPRQVIQPPNSDVE 564
            :.:|....||             :|.||.|||...|:.|..||.  ||. ||.|:|:..| |.|:
Zfish    76 DSYRLKERLT-------------ENDDFILVPAEAWRKLLSWYDMMDNQPPLERKVVDLP-STVK 126

  Fly   565 LELYPLNLRILLHQAQPSQTGVGGGTQLGSWGSTVSGGYGVLASGGGYAAIAVSSVLQPPKRYLA 629
            :|:||:.:.:.|                                         ||.|:.     .
Zfish   127 VEVYPVEIYLCL-----------------------------------------SSNLES-----T 145

  Fly   630 YTAAFSRLATVRQVGEFLCEQLRL-KSEDIRLWHVPQLDNGAILLEEDAMCLKELLIRDNDQLLL 693
            .||.|||...:..:.:.:.:...: ::.:.||| :..:|..:..|....|.:.:..:.....:::
Zfish   146 VTAQFSRADKIHAIHQKIRQHFDVSETAESRLW-MRSVDTSSERLRNLNMTVLDSCLSSGMTVIM 209

  Fly   694 EIRNKDLTWPEELGSLATAQCGQGAGTPGDRRRLTRSSIMSVHA--------PGATGLHNLGNTC 750
            ||||.|.|||                       .:|..||...|        ||..||.||||||
Zfish   210 EIRNADGTWP-----------------------TSRPQIMRNSADEDSYRGPPGVCGLTNLGNTC 251

  Fly   751 FMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWTATTRSVAPLKLR 815
            |||:|||.|.||.||.:||.:.::..|:|.:|.||.||::|..||:::|::|:....||.|...:
Zfish   252 FMNSALQCLSNTPPLTEYFLKNLYLEELNFSNPLGMKGEIAEAYADVIKQMWSGRHYSVVPRVFK 316

  Fly   816 FCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHA 880
            ..|..:|.||.|..||||||||.:|||.||||||||.:|.|.||:|::||||:.||.|||..|..
Zfish   317 TKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYIELRDADGRPDQEVAEEAWRNHLR 381

  Fly   881 RNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILLDGSV-PIKYG 944
            ||.|:|:|.|:|..||.:.|..|...||.||||..||:||||......||..:.||.:. |.:|.
Zfish   382 RNDSVIVDTFHGLFKSTLVCPECNKVSVTFDPFCYLSVPLPVSKERVMEVFYVSLDPTAKPTQYR 446

  Fly   945 FRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLR-TQSAKELYVYQLPEQS 1008
            ..:....:...|...||....:|||.|.|.:::|.:..::...||.|. .....:::||||
Zfish   447 LIVPKAGRVLDLCTALSQATGVPPNQMTVTDVFNHRFYRIYQSDESLSCILDRDDIFVYQL---- 507

  Fly  1009 MRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCNGHVSGLDVEGE 1073
                                  ||..:....|.:.....::..||
Zfish   508 ----------------------SSGCVDEDSDEVVLSIYMRERSH-------------------- 530

  Fly  1074 AEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCFG--------KRECMPHS 1130
                                  |...|||.|.....|          ||        :..|.|..
Zfish   531 ----------------------YRDYGSGSNSYGTSL----------FGHPLRMSVPRAHCTPEH 563

  Fly  1131 LF-CFKESLI-----LSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSME--- 1186
            |: ...|.|.     |..|.|       ..:::.....:|...::|    ..::..||...|
Zfish   564 LYQLLLERLARYVRPLDPSEE-------VEEEEEDDEEELYKAQTN----GVSDDEGEEDSEEAG 617

  Fly  1187 SSLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQP 1251
            ||..|..|.|..|.....||.           :::|..|.|         :|:|||   |:....
Zfish   618 SSKKEEEPRASNEVNEQNNGQ-----------SEASPSSEG---------EERAEE---EESSSE 659

  Fly  1252 DQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPNSE 1316
            .:..:|..|..|...|..::.....||                      ..||
Zfish   660 QERGSSTEEGQSACGSTDTTDGDQSAG----------------------AEPS------------ 690

  Fly  1317 GGTHKDLYCAVWLQVSRLLSPLPATTEQANHAADCDDSLGYDFP----FTLRAVKADGLTCAICP 1377
             |..:|               .....|....||.|..: ....|    :|.|..|
Zfish   691 -GKEED---------------EDEEEEDGEEAASCTPA-NKRHPGRRRYTERRKK---------- 728

  Fly  1378 WSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTT 1442
                                ||..|.|..||.:|.:..|              |...|:|:: :.
Zfish   729 --------------------ALFTIQAVNSNGTTERGMA--------------EAGGSISFS-SQ 758

  Fly  1443 KYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEEKLEQ-- 1505
            .|     |||||||......|.......::.|:::.:..::..  |.|..|:..||:.|.||:
Zfish   759 PY-----IAIDWDPDMKKKYYNENEAEKYIKHQSMDVPHQQTT--VQLQECIELFTTVETLEEEN 816

  Fly  1506 -WYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPYLASVP 1569
             || |..||..:.|||||.:|.||.:||:|||||:.......|...:|.||..|.|.:.:|
Zfish   817 PWY-CPTCKRHQLATKKLDLWSLPEVLIIHLKRFSYTKYSREKLDTIVEFPLRDLDFSGFL---- 876

  Fly  1570 QETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTKATASPPPTGNILR 1634
                        ||.                                  :..:|..|.|
Zfish   877 ------------LKK----------------------------------TVNSTEPPCP------ 889

  Fly  1635 QSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYAVVSHSGMLNGGHYI 1699
                                                          |.|.:|.:|.|.|..|||.
Zfish   890 ----------------------------------------------YDLISVSNHYGGLRDGHYT 908

  Fly  1700 SYASNA-TGSWYCYNDSSCREISQKPVIDPSAAYLLFYERKGLDYEPYLP-----------NIEG 1752
            |||.|. .|.||.::||......::.:: .||||||||:|:....:|.:|           :|..
Zfish   909 SYARNKDNGQWYYFDDSKVTYAREEQIV-TSAAYLLFYQRQDKIRQPSVPPPVPCSTQPENHISS 972

  Fly  1753 RTLPN----TASVPLEVD 1766
            :|..:    :|.|.:|.|
Zfish   973 QTNDSADGASACVSMETD 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	176/530 (33%)
		Peptidase_C19	<1480..1737	CDD:351799	65/260 (25%)
usp11	XP_002663119.3	UBP12	15..947	CDD:227847	344/1403 (25%)
		DUSP	34..119	CDD:283896	35/157 (22%)
		Ubiquitin_3	133..219	CDD:291502	21/132 (16%)
		Peptidase_C19	242..>419	CDD:271592	93/176 (53%)
		USP7_C2	413..>504	CDD:291217	26/90 (29%)
		Peptidase_C19R	<793..946	CDD:239139	65/258 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920