Protein Alignment Usp32 and usp43a

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001428971.1
• Gene: usp43a / 563983
• ZFINID: ZDB-GENE-100211-1
• Length: 1155
• Species: Danio rerio
• Alignment Length: 1092
• Identity: 221/1092 - (20%)
• Similarity: 339/1092 - (31%)
• Gaps: 451/1092 - (41%)

  Fly   717 GAGTPGDRRRLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAA 781
            |..|||            ||    .||.|.||||||||.:|.|.||:.||:|...|.:::|:|..
Zfish   107 GEKTPG------------VH----EGLKNHGNTCFMNAVVQCLSNTELLAEYLGLEQYKYELNER 155

  Fly   782 NKLG------TKGQLAMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWL 840
            ...|      .:|::..:.|.|::.:||........:..:..|.||..||.|..|||:.|.|.||
Zfish   156 RINGMMKSEEVRGEVTDKLASLVRALWTNDYTPQLSVDFKSVVAKYGSQFKGNAQHDALEFLLWL 220

  Fly   841 LDALHED----LNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCL 901
            ||.:|||    .|....:..|..|.|.|..:......|.||......|.:.:.|..|.:|.::|.
Zfish   221 LDCVHEDANLSTNNNQSRNSSSSKGSVGLEESSCPGPANSQQPGTRHSFVQEHFQAQYRSSLTCP 285

  Fly   902 GCGHESVRFDPFSLLSLPLPVENYIYFEV-LVILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCS 965
            .|..:|..||||..:|||:|:.......| ||...:|...::.|..:......|.|:..::....
Zfish   286 HCLKQSNTFDPFLCISLPIPLRQTRALNVTLVFSTEGQRFLRIGLAVPLFGSISTLRAMVAEEGK 350

  Fly   966 LPPNLMLVCELWNSQIRQVLNDDEKLRTQSAKE-LYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQ 1029
            |.|:.:::.|:.:...::..:|::.:.:.|..: :|.:|:|.             |..:|
Zfish   351 LSPDQVILTEMNSGGFQRSFSDEDDMTSISESDVIYAFQVPP-------------HFTRG----- 397

  Fly  1030 RSSALITSAQDSLSSLSTLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVS 1094
             .|...:....||.|                                             :|..:
Zfish   398 -GSMRFSGYHHSLPS---------------------------------------------SPYTA 416

  Fly  1095 TYSGNGSGDNQVHELLPDEAGKVSRCFGKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRV 1159
            .:.|        |.|.|
Zfish   417 DFKG--------HRLPP------------------------------------------------ 425

  Fly  1160 SSAKLLHTESNTSSMSYTNHSGENSMESSLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSGL 1224
                     |.|.|..:.||.|.:.:            |..:.:..|||
Zfish   426 ---------SGTLSTEFLNHGGSSKV------------LLLICNVAGSG---------------- 453

  Fly  1225 STGHTLGASLDVDEQAEEGNAEDHDQPDQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHRKIT 1289
                                             |..|..|        ||     :|:.|.|.
Zfish   454 ---------------------------------QQATRFG--------PP-----FLMRVERT-- 470

  Fly  1290 RHDSYFLSYHKTRPS------LFGVPLLIPNSE-------GGTHKDLYCAVWLQVSRLLSPLPAT 1341
                  ||:...:.|      :|....:|..:|       ||:....|          |||
Zfish   471 ------LSWDHLQQSVCNKLYVFQKTAIIKTTELFKVRVVGGSASCSY----------LSP---- 515

  Fly  1342 TEQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAA 1406
                      .||.....|...||:|..|
Zfish   516 ----------HDSRPLCHPTVDRALKLCG------------------------------------ 534

  Fly  1407 SNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTTKYFEDFTIAIDWDPTALHLRYQSTLERLW 1471
                        |..| |..|                      :.|:||.......:.:..|.:.
Zfish   535 ------------PGGP-LHVK----------------------LIIEWDNKIKECLFGNIQEEVI 564

  Fly  1472 VDHETIAISRREQVE--PVDLNHCLRAFTSEEKL---EQWYHCSHCKGKKPATKKLQIWKLPPIL 1531
            .|.|::.|.::..|:  ...|:.|.:.:|.||:|   :.| .|.|||..:....|:.:|.||.||
Zfish   565 EDAESVRIQQQNHVQQHSCTLDDCFQLYTKEEQLAPDDAW-KCPHCKQMQQGMVKMSLWTLPDIL 628

  Fly  1532 IVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVV 1596
            |:|||||..|..:..|...::.||....|.||::.          |....:||.|
Zfish   629 ILHLKRFRQVGKRRNKLSTLIRFPVSALDMTPHVV----------KRSQSMKNLA---------- 673

  Fly  1597 SELDEIDAPSKEVKEELPNQTGSTKATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGE 1661
                                           |..:..:..:|
Zfish   674 -------------------------------PLPSTWKHGET----------------------- 684

  Fly  1662 FEDYHQHRLKPDVDQFDPRYRLYAVVSHSGMLNGGHYISYASNAT-GSWYCYNDSSCREISQKPV 1725
                            |..|.||||.:|.|.::||||.:|..|:. |.||.|:|||. ||..:..
Zfish   685 ----------------DFLYDLYAVCNHHGGMHGGHYTAYCRNSVDGHWYSYDDSSV-EIVPEEE 732

  Fly  1726 IDPSAAYLLFYERKGLDYEPYLPN--IEGRTLPNTAS---VPLEVDETEGEL 1772
            :....||:|||:|:.: ..|:..|  :.|.|..:.:.   :.|..|...|.:
Zfish   733 LCTRGAYILFYQRRNV-IPPWSANSSVRGSTSSSMSDHWLIRLNGDSKRGSM 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	87/296 (29%)
		Peptidase_C19	<1480..1737	CDD:470612	64/262 (24%)
usp43a	NP_001428971.1	None