Protein Alignment Usp32 and usp13

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001091856.1
• Gene: usp13 / 558011
• ZFINID: ZDB-GENE-080724-7
• Length: 860
• Species: Danio rerio
• Alignment Length: 979
• Identity: 194/979 - (19%)
• Similarity: 315/979 - (32%)
• Gaps: 353/979 - (36%)

  Fly   937 GSVPIKYGFRLNSDCKYSHLKHKLSTMC------SLP--PNLMLVCELWNSQIRQVLNDDEKLRT 993
            |...::..:|......|.|||..:....      ::|  .|..:..:|   ::.:..|.|:....
Zfish    54 GREHVERHYRKTGQSVYMHLKRHVKEKATGAAGGAIPRRRNGKVFLDL---ELNRDFNGDDYEYE 115

  Fly   994 QSAKELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSA-------------QDSLSSL 1045
            ..|| |.::  |:             |.|..|.:|:...||:|.|             |:|.|..
Zfish   116 DEAK-LVIF--PD-------------HYEIPLPNIEELPALVTIACDAVLNAPSPYKKQESDSWE 164

  Fly  1046 STLQTSSHRASSRVLCNGHVSGLDVEGEAEV---GTDVSQCNSNSNY-------NPIVSTYSGNG 1100
            ..:|.|.|..|.|.|.||          ..:   |...::|....|.       :.:...:..:|
Zfish   165 EEIQVSRHARSLRQLDNG----------VRIPPSGWKCAKCEMRENLWLNLTDGSVLCGKWFFDG 219

  Fly  1101 SGDN----------------QVHELLPDEAGKVSRCFGKRECM--PHSLFCFKESLILSSSPENT 1147
            ||.|                :::.:.||.|...|  |.:.|.:  ||
Zfish   220 SGGNGHALEHYRESNFPLAVKLNTITPDGADIYS--FDEEEAVLDPH------------------ 264

  Fly  1148 FMHGAAAQQKRVSSAKLLHTESNTSSMSYT--NHSGENSMESSLT--EPIPLA--DLEPVSSRNG 1206
                        .|..|||...:...|..|  .|..:|.::..::  |.|..|  .|:||   .|
Zfish   265 ------------ISEHLLHFGIDMLQMQRTENGHHTDNHVQPRISDWEVIQEAGLKLKPV---YG 314

  Fly  1207 SGGEDCSYRTSPN--DSSGLSTGHTLGASLDVDEQAEEGNAE---DH---DQPDQITTSQPETSS 1263
            ||     |....|  :|..|||...:..|:...::|..||.:   |:   |......|...:...
Zfish   315 SG-----YTGIKNLGNSCYLSTTMQVLFSIPEFQRAYAGNLQRIFDYSPLDPTQDFNTQMAKLGH 374

  Fly  1264 GVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTR------PSLF------GVPLLIPNSE 1316
            |:.|.:.|:||.|:     .:..::.:.:      ||.:      |.:|      |.|....|.:
Zfish   375 GLLSGQYSKPPMKS-----ELIEQVMKEE------HKQQQQRGISPKMFKALVSKGHPEFSSNRQ 428

  Fly  1317 GGTHKDLYCAVWLQVSRLLSPLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSF 1381
            ...|:.|.        .|::.:......:.:.:|           ..|.:..:...|
Zfish   429 QDAHEFLL--------HLINLVERNNSGSENPSD-----------VFRFIVEERTQC-------- 466

  Fly  1382 CRGCEIRCNN--DYVLQGALP-PINAAASNTSTPKMNAK-------FPSLPNLEAKRTPEYTASL 1436
            |:..::|...  ||::|  || |:.||::.........|       ...||.:...|.| :||
Zfish   467 CQSQKVRYTQRVDYLMQ--LPVPLEAASNREELIAYEGKRKEAEENMRPLPEVVRARVP-FTA-- 526

  Fly  1437 SYTPTTKYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEE 1501
                                                                    ||:|||..|
Zfish   527 --------------------------------------------------------CLQAFTEPE 535

  Fly  1502 KLEQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKVVHFPFDDF------- 1559
            .:..:: .|..:.|....|..:....|..:||.||:|. ....||..:..:.....||
Zfish   536 NVPDFW-SSALQAKSAGVKTSRFATFPEYMIVQLKKFT-FGVDWVPKKLDMSVDVPDFLDLNRLR 598

  Fly  1560 ------------DPTPYLASVPQET-------ILRHKELLE--LKNDAEM--------------- 1588
                        |.||.:. :|::|       .|...|:.|  :...|||
Zfish   599 ATGLQAGEEELPDLTPPIV-IPEDTRDSSTNNSLESPEIDESSVMQLAEMGFPLEACRKAVYYTG 662

  Fly  1589 ----TMATNEVVSELDEID-----APSKEVKEELPNQT-GSTKATASPPPTGNI----------- 1632
                .||.|.:::.::|.|     |....::.:||:.: .:|.|..:.||..:|
Zfish   663 NMGAEMAFNWIIAHMEEPDFAEPLAVPTYMESDLPSPSLPTTSALDNQPPEESISILTSMGFPRH 727

  Fly  1633 --LRQSKTKNAVRRQRL--------------ISTSLTKTPIVDGEFEDYHQH---RLKPDVDQFD 1678
              :|..|..|....:.|              ..:....|...|..|.:.:.|   .|.||.|...
Zfish   728 HTIRALKASNNNLERALDWIFTHPDCEDESEAMSDTADTEPNDNSFSNANAHTDSSLSPDQDLSS 792

  Fly  1679 P-------RYRLYAVVSHSGMLN-GGHYISYASNATGSWYCYNDSS-CREISQKPVIDPSAAYLL 1734
            |       ||.|:|.:||.|... .|||:.:... .|.|..|||.. |  :|::|..|  ..|:.
Zfish   793 PRVRDGPGRYELFAFISHMGTSTMSGHYVCHIKK-EGRWLIYNDHKVC--LSERPPKD--LGYMY 852

  Fly  1735 FYER 1738
            ||.|
Zfish   853 FYRR 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	14/72 (19%)
		Peptidase_C19	<1480..1737	CDD:470612	77/348 (22%)
usp13	NP_001091856.1	zf-UBP_var	16..79	CDD:407678	6/24 (25%)
		zf-UBP	192..264	CDD:460464	12/73 (16%)
		Peptidase_C19B	319..855	CDD:239123	125/642 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..636		6/25 (24%)
		UBA1_UBP13	635..683	CDD:270567	10/47 (21%)
		UBA2_UBP5	711..752	CDD:270569	7/40 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	755..795		9/39 (23%)