Protein Alignment Usp32 and USP40

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001369225.1
• Gene: USP40 / 55230
• HGNCID: 20069
• Length: 1256
• Species: Homo sapiens
• Alignment Length: 1027
• Identity: 199/1027 - (19%)
• Similarity: 312/1027 - (30%)
• Gaps: 386/1027 - (37%)

  Fly   704 EELGSLATAQCGQGAGTPGDRRRLTRSSIMSVHAP----GATGLHNLGNTCFMNAALQVLFNT-- 762
            ||..:::..|.|:|        :..::..:...||    ..:|:.|.|.||::|:.||.|..|
Human     8 EEYSTVSNNQYGKG--------KKLKTKALEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPE 64

  Fly   763 --QPLAQYFQREMHRFEVNAANKLGTKG-----QLAMRYAELL---KEV-----------WTATT 806
              :.|......|:..||  ..:|...|.     ||...:|:||   :|.           ||:..
Human    65 FREALFSLGPEELGLFE--DKDKPDAKVRIIPLQLQRLFAQLLLLDQEAASTADLTDSFGWTSNE 127

  Fly   807 RSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPDKIVA 871
                  ::|              |||.||            |||::   :|.|:.|      :|.
Human   128 ------EMR--------------QHDVQE------------LNRIL---FSALETS------LVG 151

  Fly   872 AEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVEN-----------Y 925
            .   |.|     .:|..|::|.:.:::.|..|.:.|.|.:.|  |.|.:.|:|           |
Human   152 T---SGH-----DLIYRLYHGTIVNQIVCKECKNVSERQEDF--LDLTVAVKNVSGLEDALWNMY 206

  Fly   926 IYFEVLVILLDGSVPIKYGFRLNSDCKYSHLKH-----------KLSTMCSLPPNLMLVCELWNS 979
            :..||.                  ||  .:|.|           |.:.:..|||.|.:....:|.
Human   207 VEEEVF------------------DC--DNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNF 251

  Fly   980 QIRQVLNDDEKLRTQSAKELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSS 1044
            ..         ::.:..||...|..|               :...||.....|.|     |.|..
Human   252 DF---------VKCERYKETSCYTFP---------------LRINLKPFCEQSEL-----DDLEY 287

  Fly  1045 LSTL-QTSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHE 1108
            :..| ....|:..    |.|                       .:|:..:......|:...|..:
Human   288 IYDLFSVIIHKGG----CYG-----------------------GHYHVYIKDVDHLGNWQFQEEK 325

  Fly  1109 LLPDEAGKVSRCFGKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSS------------ 1161
            ..||...|..:   ..|.:.|.|...|..|:   ..||..:......||.:..
Human   326 SKPDVNLKDLQ---SEEEIDHPLMILKAILL---EEENNLIPVDQLGQKLLKKIGISWNKKYRKQ 384

  Fly  1162 ----AKLLHTESNTSSMSYTNHSGENSMESSLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSS 1222
                .|.|...|....:|....:......|||       ..|....||    :...::..|.:|.
Human   385 HGPLRKFLQLHSQIFLLSSDESTVRLLKNSSL-------QAESDFQRN----DQQIFKMLPPESP 438

  Fly  1223 GLSTGHTLGASLDV-DEQAEEGNAEDHDQPDQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHR 1286
            ||:...:.....|: |.:.:....:|.:|..|                        ||
Human   439 GLNNSISCPHWFDINDSKVQPIREKDIEQQFQ------------------------GK------- 472

  Fly  1287 KITRHDSYFLSYHKT---RP------SLFGVPLLIPNSEGGTHKDLYCAVWLQVSRLLSPLPATT 1342
                ..:|.|.|.|:   ||      ..:|||..:.|.....:      :.||..|      |..
Human   473 ----ESAYMLFYRKSQLQRPPEARANPRYGVPCHLLNEMDAAN------IELQTKR------AEC 521

  Fly  1343 EQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAAS 1407
            :.||:..:....||..:.|                                 ..|||.|:   .|
Human   522 DSANNTFELHLHLGPQYHF---------------------------------FNGALHPV---VS 550

  Fly  1408 NTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTTKYFE-DFTIAI-DWDPTALHLRYQS----- 1465
            .|.: ..:..|.....|...|.       |.....:::| |..::: ...|..||: |||
Human   551 QTES-VWDLTFDKRKTLGDLRQ-------SIFQLLEFWEGDMVLSVAKLVPAGLHI-YQSLGGDE 606

  Fly  1466 -TL-ERLWVDHETIAISRREQV-----------EPVDLNHCLRAFTSE--EKLEQWYHCSHCKGK 1515
             || |....|.|.|.:....:|           ||:.|| .|...||.  ||..|.....|.
Human   607 LTLCETEIADGEDIFVWNGVEVGGVHIQTGIDCEPLLLN-VLHLDTSSDGEKCCQVIESPHV--- 667

  Fly  1516 KPATKK-------LQIWKLPPILIVHLKRFNCVNGK-WVKSQKVVHFPFDDFDPTPYLASVPQET 1572
            .||..:       |.|    |..::.:....|..|: |..      .|.:|...|      .:|.
Human   668 FPANAEVGTVLTALAI----PAGVIFINSAGCPGGEGWTA------IPKEDMRKT------FREQ 716

  Fly  1573 ILR----------HKELLELKNDAEMTMATNEV----VSELDEIDAPSKEVK 1610
            .||          |.:...|..:.:...:.||:    |..|.::::..|:||
Human   717 GLRNGSSILIQDSHDDNSLLTKEEKWVTSMNEIDWLHVKNLCQLESEEKQVK 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	73/346 (21%)
		Peptidase_C19	<1480..1737	CDD:470612	35/166 (21%)
USP40	NP_001369225.1	peptidase_C19C	39..344	CDD:239124	85/436 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1201..1256