DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and Usp2

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_058088.2	Gene:	Usp2 / 53376	MGIID:	1858178	Length:	619	Species:	Mus musculus

Alignment Length:	480	Identity:	124/480 - (25%)
Similarity:	190/480 - (39%)	Gaps:	150/480 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   715 GQGAG-----TPGDRRRLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMH 774
            ||.:|     :||      |.::.|..|.|..||.|||||||||:.||.|.||:.|..|..:.::
Mouse   256 GQASGPSRSSSPG------RDTMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLY 314

  Fly   775 RFEVNAANKLGTKGQLAMRYAELLKEVWTATTRS-VAPLKLRFCVNKYAPQFAGGGQHDSQELLE 838
            ..::...:...|  .|...:|:|::.:||::... |:|.:.:..:.:|||:|.|..|.|:||.|.
Mouse   315 MRDLGHTSSAHT--ALMEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFMGYNQQDAQEFLR 377

  Fly   839 WLLDALHEDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGC 903
            :|||.||.::|||..:|.:..:..:..||:....:.|.::..|..|.|.|||.|||||.::|..|
Mouse   378 FLLDGLHNEVNRVAARPKASPETLDHLPDEEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDC 442

  Fly   904 GHESVRFDPFSLLSLPLPVENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCSLPP 968
            |:.|..||||..||||:....|.  ||.::                ||.....|
Mouse   443 GYCSTVFDPFWDLSLPIAKRGYP--EVTLM----------------DCMRLFTK----------- 478

  Fly   969 NLMLVCELWNSQIRQVLNDDEK-------LRTQSAKELYVYQLPEQSMRTRSNSGLSMHIEQGLK 1026
                         ..:|:.|||       .|.:..|:..|.:.|:.         |.:|:::..:
Mouse   479 -------------EDILDGDEKPTCCRCRARKRCIKKFSVQRFPKI---------LVLHLKRFSE 521

  Fly  1027 DIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYN- 1090
            ...|:|.|.|.....|..|...:.:|...:..|                             ||
Mouse   522 SRIRTSKLTTFVNFPLRDLDLREFASENTNHAV-----------------------------YNL 557

  Fly  1091 PIVSTYSGNGSGDNQVHELLPDEAGKVSRCFGKRECMPHSLFC----------FKESLI--LSSS 1143
            ..||.:||...|.:                        ::.:|          |.:|.:  :|||
Mouse   558 YAVSNHSGTTMGGH------------------------YTAYCRSPVTGEWHTFNDSSVTPMSSS 598

  Fly  1144 PENTFMHGAAAQQKRVSSAKLLHTE 1168
                        |.|.|.|.||..|
Mouse   599 ------------QVRTSDAYLLFYE 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	92/299 (31%)
		Peptidase_C19	<1480..1737	CDD:351799
Usp2	NP_058088.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..112
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..275		6/24 (25%)
		UCH	281..610	CDD:395355	114/446 (26%)
		Necessary for interaction with MDM4. /evidence=ECO:0000250\|UniProtKB:O75604	417..517		39/150 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920