Protein Alignment Usp32 and usp2a

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: XP_005157570.1
• Gene: usp2a / 494031
• ZFINID: ZDB-GENE-041212-59
• Length: 564
• Species: Danio rerio
• Alignment Length: 612
• Identity: 167/612 - (27%)
• Similarity: 248/612 - (40%)
• Gaps: 157/612 - (25%)

  Fly   583 QTGVGGGTQLGSWGSTVSGGYGV-LASGGGYAAIAVSSVLQPPKRYLAYTAAFSRLATVRQVGEF 646
            :|.:.||.:..|...|...|||. |..|.||::.   |....|..||:.:...|.::..|
Zfish    80 RTDLLGGRRSESLSRTPVKGYGSGLNGGSGYSSY---SYTPAPSSYLSSSPVSSSISLSR----- 136

  Fly   647 LCEQLRLKSEDIRLWHVPQLDNGAILLEE--DAMCLKE-LLIRDNDQLLLEIRNKDLTWPEELGS 708
                 |.......|.|    |..|:.|.|  ....||: .|.|.:|     :.:...:....||
Zfish   137 -----RKSVSQSDLTH----DLSALGLSETSSGSGLKQSYLSRGSD-----VSDSYSSSRSSLG- 186

  Fly   709 LATAQCGQGAGTPG--------DRRRLT---RSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNT 762
            |:.:...:|.|:.|        ...|.|   |.|:.|..|.|..||.|||||||||:.||.|.||
Zfish   187 LSRSSTQEGLGSSGLKSSSRFSSSYRSTSPVRESLNSKSAQGLVGLRNLGNTCFMNSILQCLSNT 251

  Fly   763 QPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWT-ATTRSVAPLKLRFCVNKYAPQFA 826
            |.|..|.....||.::|..|:  |...|...:|:|::.:|| :::.:|:|.:.:..:.:|||:|.
Zfish   252 QSLRDYCLHNSHRRDLNNNNR--THTALMEEFAKLIQTMWTSSSSEAVSPSEFKTQIQRYAPRFV 314

  Fly   827 GGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLFY 891
            |..|.|:||.|.:|||.||.::|||..:|....:|.:..||:....:.||::..|..|.|:|||.
Zfish   315 GYNQQDAQEFLRFLLDGLHNEVNRVTVRPRGNTEDFDHLPDEEKGKKMWSKYLEREDSKIVDLFV 379

  Fly   892 GQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSHL 956
            |||||.::|..||:.|..||||..||||:..:.|           |.|.:       .||.....
Zfish   380 GQLKSSLTCSECGYCSTVFDPFWDLSLPIAKKGY-----------GEVSL-------MDCMRLFT 426

  Fly   957 KHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDE-------KLRTQSAKELYVYQLPEQSMRTRSN 1014
            |                        ..||:.||       |.|.:..|:..|.:.|:.
Zfish   427 K------------------------EDVLDGDEKPTCYRCKARRRCTKKFTVQKFPKI------- 460

  Fly  1015 SGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTD 1079
              |.:|:::..:...|:|.|.|.....:..|...:.:|.|:||.|
Zfish   461 --LVLHLKRFSEARIRTSKLSTFVNFPMKDLDLREFASDRSSSAV-------------------- 503

  Fly  1080 VSQCNSNSNYN-PIVSTYSGNGSGDNQVHELLPDEAGKVSRCFGKRECMPHS--LFCFKESLILS 1141
                     || ..||.:||...|.:.           .:.|     |.|.:  .:.:.:|.:..
Zfish   504 ---------YNLYAVSNHSGTTMGGHY-----------TAYC-----CNPENGEWYTYNDSRVTP 543

  Fly  1142 SSPENTFMHGAAAQQKRVSSAKLLHTE 1168
            .|          |.|.|.|.|.:|..|
Zfish   544 MS----------ASQVRSSDAYVLFYE 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	134/441 (30%)
		Peptidase_C19	<1480..1737	CDD:470612
usp2a	XP_005157570.1	Peptidase_C19R	231..560	CDD:239139	123/436 (28%)