DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and Usp11

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001008861.2	Gene:	Usp11 / 408217	RGDID:	1303052	Length:	921	Species:	Rattus norvegicus

Alignment Length:	1403	Identity:	332/1403 - (23%)
Similarity:	494/1403 - (35%)	Gaps:	543/1403 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 DIVRGW--LRREERRPYRVGQFWYLITHDWWLSWMQYTQHTTHTCDYCKRTASQRTAVDEALVCD 447
            |:.:.|  :.....||.|.|:.|:|:...|:..|..|.:
  Rat    29 DLDQQWRQIGNGRERPLRAGESWFLVEKHWYKQWEAYVK-------------------------- 67

  Fly   448 ESFNTHSLEQHDSYSLGSGTGSASGSGSASSGISAGRHCGPVRPGPIDNSNLITANPFRNVRTLT 512
                                   .|...||:           .||.|:||.|....
  Rat    68 -----------------------GGDQDAST-----------FPGSINNSGLFEDQ--------- 89

  Fly   513 GEGGHLKRDTPLVQNHDFELVPKSLWKALNRWYG---DNLPLPRQVIQPPNSDVELELYPLNLRI 574
             ...||:.  .||:..|:.|:|...|..|..|||   |..|:.|:||:.|... ::|:||:.|
  Rat    90 -ISWHLRE--RLVEGDDYVLLPAPAWNYLVSWYGLKDDQPPIERKVIELPGIR-KVEVYPIEL-- 148

  Fly   575 LLHQAQPSQTGVGGGTQLGSWGSTVSGGYGVLASGGGYAAIAVSSVLQPPKRYLAYTAAFSRLAT 639
            ||.|....:|.:           |:...|          :.:|..|||                |
  Rat   149 LLVQHSDMETAL-----------TIQFSY----------SDSVDLVLQ----------------T 176

  Fly   640 VRQVGEFLCEQLRLKSEDIRLWHVPQLDNGAILLEEDAMCLKELLIRD-----NDQLLLEIRNKD 699
            .|:  :||.|    ..||.|||  .:...|::    |.:|..::.:.|     ...:::|.||||
  Rat   177 ARE--QFLVE----PQEDTRLW--TKNSEGSL----DRLCNTQITLLDACLETGQLVIMETRNKD 229

  Fly   700 LTWPEELGSLATAQ-CGQGAGTPGDRRRLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQ 763
            .|||       :|| ||.. ..|.:.......       ||..||.|||||||||:|||.|.|..
  Rat   230 GTWP-------SAQLCGMN-NMPDEDEDFQGQ-------PGICGLTNLGNTCFMNSALQCLSNVP 279

  Fly   764 PLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGG 828
            .|.:||....:..|:|..|.||.||:||..||:|:|:.|:...||:.|...:..|..:|.||.|.
  Rat   280 QLTEYFLNNRYLEELNFRNPLGMKGELAEAYADLVKQTWSGYHRSIVPNVFKNKVGHFASQFLGY 344

  Fly   829 GQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLFYGQ 893
            .||||||||.:|||.||||||||.:|.|.||.:..||||..||.|||..|..||.|:|:|.|:|.
  Rat   345 QQHDSQELLSFLLDGLHEDLNRVKKKEYVELCNGAGRPDLEVAQEAWQNHKRRNDSVIVDTFHGL 409

  Fly   894 LKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILLD-GSVPIKYGFRLNSDCKYSHLK 957
            .||.:.|..||:.||.||||..||:||||.:....||..:.:| ...|.::...:......|.|.
  Rat   410 FKSTLVCPDCGNVSVTFDPFCYLSVPLPVCSRRVLEVFFVPMDPRRKPEQHRVVVPKKGNISDLC 474

  Fly   958 HKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLRTQSAKELYVYQLPEQSMRTRSNSGLSMHIE 1022
            ..|||..|:.|:.|:|.::::.:..:                 :|||
  Rat   475 VALSTHTSVAPDKMIVADVFSHRFYK-----------------LYQL------------------ 504

  Fly  1023 QGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNS 1087
                            :|.||.              :|....:...:|.|..|
  Rat   505 ----------------EDPLSG--------------ILDRDDIFVYEVTGRIE------------ 527

  Fly  1088 NYNPIVSTYSGNGSGDNQV-----HELLPDEAGKVSRCFGKRECMPHSLFCFKESLILSSSPENT 1147
               |:      .||.|:.|     .|..|      ||.:....   :.|..|...|:: |.|.:.
  Rat   528 ---PV------EGSRDDIVVPVYLRERTP------SRDYNNSY---YGLILFGHPLLV-SVPRDR 573

  Fly  1148 FMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSMESSLTEPIPLADLEPVSSRNGSG---G 1209
            |                 ..|...:.:.|       .:...:|:|         :|.:..|   |
  Rat   574 F-----------------SWEGLYNILMY-------RLSRYVTKP---------TSDDDDGDEKG 605

  Fly  1210 EDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTSQPETSSGVYSRRSSQPP 1274
            ::.......:|||            ..:|:.|.....|:|...:....|..|||||..|
  Rat   606 DENEDEDVEDDSS------------SEEEKEEMSGPTDNDGTQESEQEQAGTSSGVTGR------ 652

  Fly  1275 HKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPNSEGGTHKDLYCAVWLQVSRLLSPLP 1339
                                             .|.|:.||       |:.:.|        |..
  Rat   653 ---------------------------------CPSLLDNS-------LHTSQW--------PPR 669

  Fly  1340 ATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINA 1404
            ...:|.               |||:.|.::|
  Rat   670 RRRKQL---------------FTLQTVNSNG---------------------------------- 685

  Fly  1405 AASNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTTKYFEDFTIAIDWDPTALHLRYQSTLER 1469
            .:..|::|:           ||:..|                  .||:||:|......|......
  Rat   686 TSDRTTSPE-----------EAQTQP------------------YIAMDWEPEMKRRYYDEVEAE 721

  Fly  1470 LWVDHETIAISRREQVEPVDLNHCLRAFTSEEKLEQ---WYHCSHCKGKKPATKKLQIWKLPPIL 1531
            .:|.|:.:....::  .||.|..|::.||:.|.||:   || ||.||..:.|||||.:|.||.:|
  Rat   722 GYVKHDCVGYMLKK--NPVQLKECIKLFTTVETLEKENPWY-CSSCKQHQLATKKLDLWMLPEVL 783

  Fly  1532 IVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVV 1596
            |:|||||:.......|...:|.||..|.|.:.:              :::.||::
  Rat   784 IIHLKRFSFSKFSREKLDTLVQFPIRDLDFSEF--------------VIKPKNES---------- 824

  Fly  1597 SELDEIDAPSKEVKEELPNQTGSTKATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGE 1661

  Rat   825 ----------------------------------------------------------------- 824

  Fly  1662 FEDYHQHRLKPDVDQFDPRYRLYAVVSHSGMLNGGHYISYASNA-TGSWYCYNDSSCREISQKPV 1725
                     .||:.::|    |.||.:|.|.:..|||.::|.|. :|.|:.::|:|...:::..
  Rat   825 ---------APDLYKYD----LIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQ- 875

  Fly  1726 IDPSAAYLLFYERKGLD-YEPYLPNIEGRTLPNTASVP 1762
            |:..|||:|||:|:.:. .:....:.|..|.|.::|.|
  Rat   876 IESKAAYVLFYQRQDVGRRQSQTASSETPTSPASSSTP 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	178/525 (34%)
		Peptidase_C19	<1480..1737	CDD:351799	61/260 (23%)
Usp11	NP_001008861.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		332/1403 (24%)
		UBP12	23..888	CDD:227847	326/1376 (24%)
		DUSP	44..136	CDD:197831	34/163 (21%)
		Ubiquitin_3	154..233	CDD:291502	27/127 (21%)
		Peptidase_C19	<254..>370	CDD:271592	62/115 (54%)
		Peptidase_C19	258..>437	CDD:271592	95/178 (53%)
		USP7_C2	428..>541	CDD:291217	36/198 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	592..697		35/239 (15%)
		Peptidase_C19R	<736..887	CDD:239139	61/254 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	893..921		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920