DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and Usp15-31

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster

Alignment Length:	1056	Identity:	223/1056 - (21%)
Similarity:	340/1056 - (32%)	Gaps:	396/1056 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   715 GQGAGTPGDRRRLTRSSIMSVHA---PGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRF 776
            |.|||.||...|:.........|   ||..||.|.||||||||.||.|.:|..||:||..:.::.
  Fly   236 GGGAGGPGGGERVPPIGGYQWPADQTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKA 300

  Fly   777 EVNAANKL-----GTKGQLAMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQEL 836
            ::...||:     ||||:|..:.|.:||.:||....|......:..|::|..||....|||:||.
  Fly   301 DLKRRNKINSRKFGTKGELTEQLANVLKALWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEF 365

  Fly   837 LEWLLDALHEDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCL 901
            |.||||.:|||||...::.|..||:|.||.|:::|||..:.|...|.|.:..:|..|.:|.::|.
  Fly   366 LFWLLDKVHEDLNTASKRRYKSLKNSYGRSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCP 430

  Fly   902 GCGHESVRFDPFSLLSLPLP-VENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCS 965
            .|..:|..||||..:|:.|| :.....|..:|.:......::.|.|:.:......|:.:|.....
  Fly   431 RCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTG 495

  Fly   966 LPPNLMLVCELWNSQIRQVLNDDEKLRTQSAKE-LYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQ 1029
            :..:.|::.:|......:|..|.:.:.|.|:.| :|..::|..:
  Fly   496 IEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETIYCIEVPAAT--------------------- 539

  Fly  1030 RSSALITSAQDSLSSLSTLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVS 1094
                                                                         |:..
  Fly   540 -------------------------------------------------------------PVAK 543

  Fly  1095 TYSGNGSGDNQVHELLPDEAGKVSRCFGKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRV 1159
            ..:.:.:||                                     .|:|.......||||
  Fly   544 AATPSETGD-------------------------------------KSAPTAVTPSPAAAQ---- 567

  Fly  1160 SSAKLLHTESNTSSMSYTNHSGENSMESSLTEPIPLADL----EPVSSRNGSGGEDCSYRTSPND 1220
            |.|.||...:|.    |....|              ||:    .|.|.:   ...||||:
  Fly   568 SQADLLLLVANV----YRAKDG--------------ADITRFGAPFSMK---APRDCSYQ----- 606

  Fly  1221 SSGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVH 1285
                          |:.::...         :.....:||.
  Fly   607 --------------DLQKRMLR---------EMAPLLKPEV------------------------ 624

  Fly  1286 RKITRHDSYFLSYHKTRPSLFGVPLLIPNSEGGTHKDLYCAVWLQVSRLLSPLPATTEQANHAAD 1350
                      .||......:|.:.|..|:::..|:.:       ||..     |..||..:.|
  Fly   625 ----------FSYATPLAEMFRIRLQDPSADPDTYLE-------QVEH-----PLLTEMIDMA-- 665

  Fly  1351 CDDSLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMN 1415

  Fly   666 ----------------------------------------------------------------- 665

  Fly  1416 AKFPSLPNLEAKRTPEYTASLSYTPTTKYFEDFTIAIDW-DPTALHLRYQSTLERLWVDHETIA- 1478
                 |..|.::..|::               ..:.::| .|.|..:..|...|...|:||::|
  Fly   666 -----LSVLSSEAGPQH---------------IKLLLEWSSPEAHFISKQQDTEEAVVEHESVAR 710

  Fly  1479 --ISRREQVEPVDLNHCLRAFTSEEKL--EQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFN 1539
              .|:......:.|..||..:|..|.|  |..:.|.||:...|..|.|.:|.||.||:||.|||.
  Fly   711 LSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFR 775

  Fly  1540 CVNGKWVKSQK---VVHFPFDDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDE 1601
            ....|..::.|   :|.||...||.:|:||
  Fly   776 QHQSKGPQAAKLTTMVKFPLTAFDMSPHLA----------------------------------- 805

  Fly  1602 IDAPSKEVKEELPNQTGSTKATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYH 1666
                 :.|.|...:..|.        .||..|......|..::.|.:               |..
  Fly   806 -----RGVHESASSSLGM--------GTGIGLGLGLGSNPWKKARSV---------------DSR 842

  Fly  1667 QHRLKPDVDQFDPRYRLYAVVSHSG-MLNGGHYISYASNA-TGSWYCYNDSSCREISQKPV---I 1726
            ...|....|..|.||.||||..|.| .|..|||.:...|. ...||.::|....::.:..:   |
  Fly   843 SSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDI 907

  Fly  1727 DPSAAYLLFYERKGLD 1742
            ..:.||:|||:|:.:|
  Fly   908 INNEAYMLFYQRRSVD 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	101/296 (34%)
		Peptidase_C19	<1480..1737	CDD:351799	67/266 (25%)
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	53/120 (44%)
		Peptidase_C19	266..>461	CDD:271592	78/194 (40%)
		Peptidase_C19R	<713..918	CDD:239139	67/267 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46646
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020