DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and Usp20-33

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	820	Identity:	162/820 - (19%)
Similarity:	251/820 - (30%)	Gaps:	341/820 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 QGAGTPGDRRRLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQR--EMHRFEV 778
            :|:||                  |..||.|:.|||:||:|||.|.|..|:..||..  ::..:..
  Fly    73 KGSGT------------------GLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIA 119

  Fly   779 NAANKLGTKGQLAMRYAELLKEVWTAT---TRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWL 840
            ..:.:....|.||..|..|::|:|...   ...:||..:.:.:....|.|.|..|||:||.|...
  Fly   120 EQSARRCKPGGLAKSYRRLMQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCF 184

  Fly   841 LDALHEDLNR----------------VMEKPYSELKDSN-------------------------- 863
            :|.|||:|..                :.::..||..|.|
  Fly   185 MDQLHEELTEQVSMLPQTQNQPQYQSLQQQQPSETDDENDDEAAPASLSHASESEYDTCESSMSE 249

  Fly   864 -----------------------GRPD--KIVAAEAWSQHHARN------------QSIIIDLFY 891
                                   |.|:  .:...:|..||..:|            :|||.|:|.
  Fly   250 RSAEVLLKTEYFVTPCRTNGSNSGLPEGHSVQLQQAPLQHQQKNASSAEQKPIEAARSIISDVFD 314

  Fly   892 GQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSHL 956
            |:|.|.|.||.|...|.|.:.|..||||:|  |..:..||                       |.
  Fly   315 GKLLSSVQCLTCDRVSTREETFQDLSLPIP--NRDFLNVL-----------------------HQ 354

  Fly   957 KHKLSTM------CSLPPNLMLVCELWN--------------SQIRQVLNDDE------------ 989
            .|.||..      .|...|...:..:||              ..:....:.||
  Fly   355 THSLSVQSLNAAETSARTNEGWLSWMWNMLRSWIYGPSVTLYDCMASFFSADELKGDNMYSCERC 419

  Fly   990 -KLRTQSAKELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSA--------------Q 1039
             |||| ..|...|..|||.         |.:|:::...|:..||.:.:..              :
  Fly   420 NKLRT-GIKYSRVLTLPEV---------LCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYIHK 474

  Fly  1040 DSLSSLSTLQTSSHRASSRVLC-NGHVSG-----------------LDVEGEAEVGTD-VSQCNS 1085
            |..|.::....||      |:| :|.|.|                 .|.:...||.:: |..|.:
  Fly   475 DCKSEVAIYNLSS------VICHHGTVGGGHYTCFARNTLNGKWYEFDDQFVTEVSSELVQSCQA 533

  Fly  1086 N---------------------SNYNPI----------------VSTYSGNGSGDNQVHELLPDE 1113
            .                     |..:|:                ::|:|..|..:||  |:|
  Fly   534 YVLFYHKHNPQMKLVRDEAMTLSTSHPLCDSDIQFYITREWLSRLATFSEPGPINNQ--EML--- 593

  Fly  1114 AGKVSRCFGKRECMPHSLFCFKESLILS------SSP-----ENTFMHGAAAQ-------QKRVS 1160
                        | ||......::.::|      |.|     ..||..|.|..       .||
  Fly   594 ------------C-PHGGILHSKADVISQIAVPISQPLWDYLYRTFGGGPAVNIIFECEICKR-- 643

  Fly  1161 SAKLLHTESNTSSMSYTNHSG-ENSMESSLTEPIPL---------------ADLEPVS------- 1202
            :|:.|..........:|.::| :|..:|:....|.:               .|..|::
  Fly   644 AAETLSRRQQYELNEFTKYNGLQNEFDSTAIYAIAMPWLRSWQQFSRGKTHKDPGPITNEGIAAP 708

  Fly  1203 SRNGS----------------------------GGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQ 1239
            :.|||                            ||.:...|.:.:|.........:....:.|:.
  Fly   709 TENGSATVSCVRLGSDYAQLNARLWRFLHNIYGGGPEIILRQALSDEDDAEEIEIIDQDDECDDD 773

  Fly  1240 AE---EGNAEDHD---QPDQITTSQPETSSGVYSRRSSQP 1273
            .:   ||..||.:   ...|...|..|::.|:.:..|..|
  Fly   774 EDQDLEGEGEDEEIAAASYQHNHSDTESNLGIRNTPSPSP 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	91/402 (23%)
		Peptidase_C19	<1480..1737	CDD:351799
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	110/499 (22%)
		Peptidase_C19	80..>204	CDD:271592	39/123 (32%)
		Peptidase_C19R	307..538	CDD:239139	61/271 (23%)
		DUSP	560..643	CDD:197831	18/100 (18%)
		DUSP	667..755	CDD:197831	11/87 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010