DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and Usp20

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001101297.1	Gene:	Usp20 / 311856	RGDID:	1305621	Length:	915	Species:	Rattus norvegicus

Alignment Length:	1042	Identity:	184/1042 - (17%)
Similarity:	260/1042 - (24%)	Gaps:	541/1042 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly   739 GATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWT 803
            |.||:.||||:|:||||||.|.|..||.|:|      .|.....:...|..|...|.:|:.|||.
  Rat   143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFF------LECGGLVRTDKKPALCKSYQKLISEVWH 201

  Fly   804 ATTRS-VAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPD 867
            ....| |.|..|...:....|.|.|..|.|:||.|..|:|.|||:|...|
  Rat   202 KKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPM--------------- 251

  Fly   868 KIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLV 932
              |||
  Rat   252 --VAA------------------------------------------------------------ 254

  Fly   933 ILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLRTQSAK 997

  Rat   255 ----------------------------------------------------------------- 254

  Fly   998 ELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCN 1062
                                              .|.:|.|:||.||.:..:....|:.|.
  Rat   255 ----------------------------------VAALTDARDSDSSDTDERRDGDRSPSE---- 281

  Fly  1063 GHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCFGKRECM 1127
                           .:...|:|:|:.........|.||...::..|:.||||:
  Rat   282 ---------------DEFLSCDSSSDRGEGDGQGRGGGSSKAEMELLISDEAGR----------- 320

  Fly  1128 PHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSMESSLTEP 1192
                                    |.::::|:...|....:..|:|
  Rat   321 ------------------------AISEKERMKDRKFSWGQQRTNS------------------- 342

  Fly  1193 IPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTS 1257
                  |.|.       ||....|               |...:|||:.|.     ..|....||
  Rat   343 ------EQVD-------EDADVDT---------------AMASLDEQSREA-----QPPSPRPTS 374

  Fly  1258 ---QPETSSGVYSRRSSQP----PHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLL---- 1311
               .||..:.|:.|.||:|    .|..|      |.|::.      |..:..|...|...:
  Rat   375 PCQTPEPDNEVHIRSSSRPCSPVHHHEG------HTKLSS------SPPRASPVRMGPSYVLKKA 427

  Fly  1312 -IPNSEGGTHKD------------------LYCAVWLQVSR-------LLSPLPATTEQAN-HAA 1349
             :|::.|...|:                  :.|....:||.       |..|:|...:.|. |:|
  Rat   428 QVPSTGGRRRKEQSYRSVISDVFNGSVLSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSA 492

  Fly  1350 DCDDSLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKM 1414
                 :..:.|....|                       |.:.|..||.|..|
  Rat   493 -----IYQNVPAKPGA-----------------------CGDSYSSQGWLAFI------------ 517

  Fly  1415 NAKFPSLPNLEAKRTPEYTASLSYTPTTKYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAI 1479
                           .||......:.|..:|        |.|.
  Rat   518 ---------------VEYIRRFVVSCTPSWF--------WGPV---------------------- 537

  Fly  1480 SRREQVEPVDLNHCLRAFTSEEKL--EQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVN 1542
                    |.|..||.||.:.::|  :..|.|..||..:...|..::..||.||.||||||....
  Rat   538 --------VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLCLPEILCVHLKRFRHEV 594

  Fly  1543 GKWVKSQKVVHFPFDDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSK 1607
            ....|....|.||.:..|..|:||          ||            .|::|.:
  Rat   595 MYSFKVSSHVSFPLEGLDLRPFLA----------KE------------CTSQVTT---------- 627

  Fly  1608 EVKEELPNQTGSTKATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKP 1672

  Rat   628 ----------------------------------------------------------------- 627

  Fly  1673 DVDQFDPRYRLYAVVSHSGMLNGGHYISYASNA-TGSWYCYNDSSCREISQKPVIDPSAAYLLFY 1736
                    |.|.:|:.|.|....||||:|..|. .|.||.::|....|: .:.|:....||:|||
  Rat   628 --------YDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEV-HETVVQNVEAYVLFY 683

  Fly  1737 ER 1738
            .:
  Rat   684 RK 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	50/263 (19%)
		Peptidase_C19	<1480..1737	CDD:351799	55/259 (21%)
Usp20	NP_001101297.1	UBP14	<8..>260	CDD:227532	51/298 (17%)
		UCH	145..683	CDD:395355	181/1036 (17%)
		DUSP	703..786	CDD:197831
		DUSP	811..895	CDD:197831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000