Protein Alignment Usp32 and Usp13

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001101135.1
• Gene: Usp13 / 310306
• RGDID: 1306044
• Length: 858
• Species: Rattus norvegicus
• Alignment Length: 814
• Identity: 154/814 - (18%)
• Similarity: 262/814 - (32%)
• Gaps: 279/814 - (34%)

  Fly   511 LTGEGGHLKRDTPLVQNHDFELVPKSLWKALNRWYGDNL-PLPRQVIQPPNS------DVELELY 568
            |:.:..:.|:|....:|.    :|.|.       |.:|| .|...|..||:.      |:...|:
  Rat   166 LSSKSPYRKQDPDTWENE----LPVSK-------YANNLVQLDNGVRIPPSGWKCARCDLRENLW 219

  Fly   569 PLNLRILLHQAQPSQTGVGGGTQLGSWGSTVSGGYGVLASGGGYAAIAVSSVLQPPKRYLAYTAA 633
             |||             ..|....|.|....||       |.|:|.        ...|.:.|..|
  Rat   220 -LNL-------------TDGSVLCGKWFFDSSG-------GNGHAL--------EHYRDMGYPLA 255

  Fly   634 FSRLATVRQVG----EFLCE--------QLRLKSEDIRLWHVPQLDNGAILLEEDAMCLKELLIR 686
            . :|.|:...|    .|..|        ...|....|.:.|....:||               .|
  Rat   256 V-KLGTITPDGADVYSFQEEGPVSDPHLAKHLAHFGIDMLHTQGTENG---------------FR 304

  Fly   687 DNDQLLLEIRNKDLTWPEELGSLATAQCGQGAGTPGDRRRLTRSSIMSVHAPGATGLHNLGNTCF 751
            |||   :::|..:  |          :..|.:||          .:..::.||.|||.||||:|:
  Rat   305 DND---IKLRVSE--W----------EVIQESGT----------KLKPMYGPGYTGLKNLGNSCY 344

  Fly   752 MNAALQVLFNT-----------------QPL--AQYFQREMHRFEVNAANKLGTKGQLAMRYA-- 795
            :::.:|.:|:.                 .||  .|.|..:|        .||| .|.|:.:|:
  Rat   345 LSSVMQAIFSIPEFQRAYVGNLPRIFDYSPLDPTQDFNTQM--------TKLG-HGLLSGQYSKP 400

  Fly   796 --------ELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRV- 851
                    :::||........::|...:..|:|..|:|:...|.|:||....|::.:  :.||:
  Rat   401 PVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLV--ERNRIG 463

  Fly   852 MEKPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDP--FS 914
            .|.|                               .|:|...::.::.|  |....||:..  ..
  Rat   464 SENP-------------------------------SDVFRFLVEERIQC--CQTRKVRYTERVDY 495

  Fly   915 LLSLPLPVE------NYIYFEV-----------LVILLDGSVPIKYGFRLNSDCKYSHLKHKLST 962
            |:.||:.:|      ..|.:|:           |..|:...:|.       |.|..:..:
  Rat   496 LMQLPVAMEAATNKDELIAYELMRREAETNRRPLPELVRAKIPF-------SACLQAFAE----- 548

  Fly   963 MCSLPPNLMLVCELWNSQIRQVLNDDEKLRTQSAKELYVYQLPEQSMRTRSNSGL-----SMHIE 1022
                |.|   |.:.|:|.::......:..|..|..|..|.|:.:.:.      ||     ...:.
  Rat   549 ----PDN---VDDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTF------GLDWVPRKFDVS 600

  Fly  1023 QGLKDIQRSSAL----ITSAQDSLSSLS----TLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTD 1079
            ..:.|:...|.|    :...::.|..:|    ....|..|..::::....:....|...||:|..
  Rat   601 IDMPDLLDISHLRARGLQPGEEELPDISPPIVIPDDSKDRLMNQLIDPSDIDESSVMQLAEMGFP 665

  Fly  1080 VSQCNSNSNYNPIVSTYSGNGSGDNQ-----VHELLPDEA---------GKVSRCFGKRECMPHS 1130
            :..|..       ...::||...:..     ||...||.|         |..:..||
  Rat   666 LEACRK-------AVYFTGNTGAEVAFNWIIVHMEEPDFAEPLAIPGYGGAGASAFG-------- 715

  Fly  1131 LFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSMESSLTEPIPL 1195
                  :..|.:.|....:....|...:.|.|        ..::..|||:.|.:::...:.|...
  Rat   716 ------ATGLDNQPPEEIVAIITAMGFQRSQA--------VQALQATNHNLERALDWIFSHPEFE 766

  Fly  1196 ADLEPVSSRNGSGGEDCSYRTSP-----NDSSGL 1224
            .|.:.|.....:...:......|     .|.||:
  Rat   767 EDSDFVIEMENNANANIMSEAKPEGPRVKDGSGM 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	112/558 (20%)
		Peptidase_C19	<1480..1737	CDD:470612
Usp13	NP_001101135.1	zf-UBP_var	33..96	CDD:407678
		zf-UBP	209..282	CDD:460464	21/102 (21%)
		Peptidase_C19B	335..854	CDD:239123	103/564 (18%)
		UBA1_UBP13	650..698	CDD:270567	11/54 (20%)
		UBA2_UBP5	723..764	CDD:270569	8/48 (17%)