DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and Usp16

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_006248077.1	Gene:	Usp16 / 288306	RGDID:	1307192	Length:	826	Species:	Rattus norvegicus

Alignment Length:	1072	Identity:	197/1072 - (18%)
Similarity:	301/1072 - (28%)	Gaps:	518/1072 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   742 GLHNLGNTCFMNAALQVLFNTQPLAQYFQREM-----------------HRFEVNAANKLGTKGQ 789
            ||.|||||||.||.:|.|..| |:.:...:|:                 ...|||    |...|.
  Rat   196 GLSNLGNTCFFNAVMQNLSQT-PVLRELLKEVKMSGTIVKIEPPDLALTEPLEVN----LEPPGP 255

  Fly   790 LAMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALH-EDLNRVME 853
            |.:..::.|.|:.....|.|.|.:|...|.|.|.:|.|..|.||||||.:|||.:. |:..||.:
  Rat   256 LTLAMSQFLNEMQENKKRIVTPKELFSQVCKKATRFKGYQQQDSQELLRYLLDGMRAEEHQRVSK 320

  Fly   854 KPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIID-LFYGQLKSKVSCLGCGHESVRFDPFSLLS 917
            .......:|..:.|:.|..:.......:.....:| :|.|:|.|.:.|..|...|:..:.|..||
  Rat   321 GILKAFGNSTEKLDEEVKNKVKDYEKKKAIPSFVDRIFGGELTSTIMCDDCRTVSLVHESFLDLS 385

  Fly   918 LPLPVENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIR 982
            ||:                          |:......::..|                    .::
  Rat   386 LPV--------------------------LDDQSGKKNINDK--------------------NVK 404

  Fly   983 QVLNDDEKLRTQSAKELYVYQLPEQSMRTRSN--SGLSMHIEQGLKDIQRSSALITSAQDSLSS- 1044
            :.:.:::|...:...:.|        |:|||:  ||.|.|.::..|...:..|.....|..:..
  Rat   405 KTMEEEDKDSEEEKDDSY--------MKTRSDVPSGTSKHTQKKAKKQAKKQAKNQRRQQKIQER 461

  Fly  1045 ---LSTLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQV 1106
               .:.:.|:::...     |.|.:...:.||.||.|:.::.:........:.....:.:|..::
  Rat   462 FLHFNEICTTNYTED-----NDHEAETALPGEGEVDTEFNRGSQEELTQTELCANQKDVNGQEEM 521

  Fly  1107 HELLPDEAGKVSRCFGKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNT 1171
            .|...||          |:|..|              ||                .|.:.|||:.
  Rat   522 IESAADE----------RKCPEH--------------PE----------------VKSVSTESDL 546

  Fly  1172 SSMSYTNHSGENSMESSLTEPIPLADLEPVSSRNGSGGEDCSYRTSP--NDSSGLSTGHTLGASL 1234
            .|::              :.|....||      ||:..|:   |||.  :.::||. ..||.|::
  Rat   547 GSLT--------------SAPECPRDL------NGAFLEE---RTSGELDITNGLK-NLTLNAAV 587

  Fly  1235 DVDEQAEEGNAEDHDQPDQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYH 1299
            |               ||:|:..                               ..:||:
  Rat   588 D---------------PDEISIE-------------------------------ILNDSH----- 601

  Fly  1300 KTRPSLFGVPLLIPNSEGGTHKDLYCAVWLQVSRLLSPLPATTEQANHAADCDDSLGYDFPFTLR 1364
                                                ||.....|..|     :|
  Rat   602 ------------------------------------SPALKVYEVMN-----ED----------- 614

  Fly  1365 AVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRT 1429
                        |.::||                                     :|.|.||..|
  Rat   615 ------------PETAFC-------------------------------------TLANREAFST 630

  Fly  1430 PEYTASLSYTPTTKYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEPVDLNHCL 1494
            .|                                                        ..:.|||
  Rat   631 DE--------------------------------------------------------CSIQHCL 639

  Fly  1495 RAFTSEEKLEQWYH--CSHC------------KGKKP-----ATKKLQIWKLPPILIVHLKRFNC 1540
            ..||..|||:....  |..|            ||::.     |.|::.:...||:|.:|||||..
  Rat   640 YQFTRNEKLQDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLVSLAPPVLTLHLKRFQQ 704

  Fly  1541 VNGKWVKSQKVVHFPFDDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAP 1605
            ......|..|.:.||                      |:|:|                     ||
  Rat   705 AGFNLRKVNKHIKFP----------------------EILDL---------------------AP 726

  Fly  1606 -----SKEVKEELPNQTGSTKATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDY 1665
                 .|.|.||      ||:..
  Rat   727 FCTLKCKNVAEE------STRVL------------------------------------------ 743

  Fly  1666 HQHRLKPDVDQFDPRYRLYAVVSHSGMLNGGHYISYASNAT------------------------ 1706
                           |.||.||.|||.:..|||.:||...|
  Rat   744 ---------------YSLYGVVEHSGTMRSGHYTAYAKERTASCHLSNLVLHGDIPQDCEMESTK 793

  Fly  1707 GSWYCYNDSSCREISQKPVIDPSAAYLLFYER 1738
            |.|:..:|:..:.:....|:: |.||||||||
  Rat   794 GQWFHISDTHVQAVPITKVLN-SQAYLLFYER 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	66/278 (24%)
		Peptidase_C19	<1480..1737	CDD:351799	61/304 (20%)
Usp16	XP_006248077.1	zf-UBP	48..122	CDD:280334
		Peptidase_C19K	196..>401	CDD:239132	63/235 (27%)
		UCH	196..>393	CDD:278850	63/227 (28%)
		Peptidase_C19K	<625..823	CDD:239132	65/360 (18%)
		UCH	<634..822	CDD:278850	60/294 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910