Protein Alignment Usp32 and USP49

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001273483.1
• Gene: USP49 / 25862
• HGNCID: 20078
• Length: 688
• Species: Homo sapiens
• Alignment Length: 725
• Identity: 161/725 - (22%)
• Similarity: 255/725 - (35%)
• Gaps: 232/725 - (32%)

  Fly   559 PNSDVELELYPLNLRILLHQAQPSQTGVGGGTQLGSWGSTVSGGYGVLASGGGYAAIAVSSVLQP 623
            |..|::|    |...:|..:.|...|.|..|..|.|           :|||        ..|:.|
Human    88 PEGDLKL----LRSSLLAVRGQKQDTPVRRGRTLRS-----------MASG--------EDVVLP 129

  Fly   624 PKRYLAYTAAFSRLATVRQVGEFLCEQLRLKSEDIRLWHVPQLDNGAILLE----EDAM------ 678
            .:.........:.|...||         ||.:..:||| ..:...|...||    |:|:
Human   130 QRAPQGQPQMLTALWYRRQ---------RLLARTLRLW-FEKSSRGQAKLEQRRQEEALERKKEE 184

  Fly   679 -----------CLKELLI---RDNDQLLLEIRNKDLTWPEELGSLATAQCGQGAGTPGDRR---- 725
                       .|:||..   |.:.:|||..       |.:.|..|:    :.|..|..||
Human   185 ARRRRREVKRRLLEELASTPPRKSARLLLHT-------PRDAGPAAS----RPAALPTSRRVPAA 238

  Fly   726 --RLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQPLAQYF-----QREMHRF--EVNAA 781
              :|.|...|   |||.|||.||||||:||:.||||.:.|...:.|     .:..|.|  ..|..
Human   239 TLKLRRQPAM---APGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGK 300

  Fly   782 NKLGTK------GQLAMR--YAE----------------------------------------LL 798
            .:|..|      .:|::|  .||                                        |.
Human   301 TQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLF 365

  Fly   799 KEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSN 863
            :.:|:.....|:|..:...|....|.|.|..|.|:||.|..||..:.::|            :|.
Human   366 RVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL------------ESE 418

  Fly   864 GRPDKIVAAEAWSQHHARNQ--SIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYI 926
            |...:|:.  .:||.....|  .::..:|:|||.|:|:|:.|.::|...:||..|||..| |.|.
Human   419 GTTRRILI--PFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFP-ERYH 480

  Fly   927 YFEVLVILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKL 991
            ..|      .|.||:.     .::|..:.:..|.:...:|...: ..|:..||: |:..|....:
Human   481 CIE------KGFVPLN-----QTECLLTEMLAKFTETEALEGRI-YACDQCNSK-RRKSNPKPLV 532

  Fly   992 RTQSAKELYVYQLPE-----------QSMRTRSNSGLSMHIEQGLKDIQRSSALIT----SAQDS 1041
            .:::.|:|.:|:||:           .....|...|:.:..:|          ::|    ..:|.
Human   533 LSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQ----------VLTMEPYCCRDM 587

  Fly  1042 LSSLSTLQTSSHRASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQV 1106
            ||||.. :|.::..|:.|:.:|...|                  :.:|    :.|..|..|...|
Human   588 LSSLDK-ETFAYDLSAVVMHHGKGFG------------------SGHY----TAYCYNTEGGFWV 629

  Fly  1107 HELLPDEAGKVSRCFGKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNT 1171
            |    ....|::.|..:..|...:...|                  ..|:....:|::..|....
Human   630 H----CNDSKLNVCSVEEVCKTQAYILF------------------YTQRTVQGNARISETHLQA 672

  Fly  1172 SSMSYTNHSG 1181
            ...|..|..|
Human   673 QVQSSNNDEG 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	128/529 (24%)
		Peptidase_C19	<1480..1737	CDD:470612
USP49	NP_001273483.1	zf-UBP	26..87	CDD:460464
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..230		15/71 (21%)
		UCH	253..654	CDD:425685	106/483 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..315		4/21 (19%)