DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and USP33

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_055832.3	Gene:	USP33 / 23032	HGNCID:	20059	Length:	942	Species:	Homo sapiens

Alignment Length:	1046	Identity:	183/1046 - (17%)
Similarity:	278/1046 - (26%)	Gaps:	511/1046 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   735 VHAPGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLK 799
            :.|.|.|||.|:||||:||||||.|.|..||.|:|      .:.....:...|..:...|.:|:.
Human   179 LRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFF------LDCGGLARTDKKPAICKSYLKLMT 237

  Fly   800 EVW-TATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSN 863
            |:| .:...||.|..|...:....|.|.|..|.|:||.|..|:|.|||           |||:
Human   238 ELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHE-----------ELKE-- 289

  Fly   864 GRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYF 928

Human   290 ----------------------------------------------------------------- 289

  Fly   929 EVLVILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLRT 993
                                                               |:.:|..|.:.:.|
Human   290 ---------------------------------------------------QVMEVEEDPQTITT 303

  Fly   994 QSAKELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSR 1058
            :...|
Human   304 EETME------------------------------------------------------------ 308

  Fly  1059 VLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCFGK 1123
                        |.:::...|...|.|.||     |..:.|.:|               ||||.:
Human   309 ------------EDKSQSDVDFQSCESCSN-----SDRAENENG---------------SRCFSE 341

  Fly  1124 RECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGE-NSMES 1187
            ..         .|:.:|....||           ....:|....|...:.::..|..|| :....
Human   342 DN---------NETTMLIQDDEN-----------NSEMSKDWQKEKMCNKINKVNSEGEFDKDRD 386

  Fly  1188 SLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPD 1252
            |::|.:.|.:.|.|..:..|...:  |.|..: |:.|||...|
Human   387 SISETVDLNNQETVKVQIHSRASE--YITDVH-SNDLSTPQIL---------------------- 426

  Fly  1253 QITTSQPETSSGVYSRRSSQPPHKAGKY---LVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPN 1314
                   .::.||..|.|:.|| |:|..   |...|:|...........||...|     ::...
Human   427 -------PSNEGVNPRLSASPP-KSGNLWPGLAPPHKKAQSASPKRKKQHKKYRS-----VISDI 478

  Fly  1315 SEGGTHKDLYC------AVWLQVSRLLS-PLPATTEQAN-HAADCDDSLGYDFPFTLRAVKADGL 1371
            .:|.....:.|      :|.|:..:.|| |:|...:.|. |::....|:          |||..
Human   479 FDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSI----------VKAGS- 532

  Fly  1372 TCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTASL 1436
                             |...|..||.:                |.|           .||....
Human   533 -----------------CGEAYAPQGWI----------------AFF-----------MEYVKRF 553

  Fly  1437 SYTPTTKYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEE 1501
            ..:....:|        |.|.                              |.|..||.||.:.:
Human   554 VVSCVPSWF--------WGPV------------------------------VTLQDCLAAFFARD 580

  Fly  1502 KL--EQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKV---VHFPFDDFDP 1561
            :|  :..|.|..||..:...|..::...|.||.:|||||   ..:.:.|.|:   |.||.:..|.
Human   581 ELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRF---RHELMFSTKISTHVSFPLEGLDL 642

  Fly  1562 TPYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTKATASP 1626
            .|:||.                                   |:|::.|
Human   643 QPFLAK-----------------------------------DSPAQIV----------------- 655

  Fly  1627 PPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYAVVSHSG 1691
                                                                 .|.|.:|:.|.|
Human   656 -----------------------------------------------------TYDLLSVICHHG 667

  Fly  1692 MLNGGHYISYA-SNATGSWYCYNDSSCREISQKPVIDPSAAYLLFYERKGLDYEPYLPNIEGRTL 1755
            ..:.||||:|. :|....||.::|.|..|:|:. .:..:.||:|||.:...:.:.     |.|.:
Human   668 TASSGHYIAYCRNNLNNLWYEFDDQSVTEVSES-TVQNAEAYVLFYRKSSEEAQK-----ERRRI 726

  Fly  1756 PNTASV 1761
            .|..::
Human   727 SNLLNI 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	52/267 (19%)
		Peptidase_C19	<1480..1737	CDD:351799	53/262 (20%)
USP33	NP_055832.3	zf-UBP	61..121	CDD:280334
		UCH	184..712	CDD:278850	176/1014 (17%)
		Peptidase_C19	186..>288	CDD:271592	42/118 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..357		21/174 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..469		15/79 (19%)
		Peptidase_C19R	473..713	CDD:239139	79/446 (18%)
		DUSP	734..803	CDD:299905
		DUSP	840..924	CDD:197831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910