DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and Usp4

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_006511759.1	Gene:	Usp4 / 22258	MGIID:	98905	Length:	967	Species:	Mus musculus

Alignment Length:	1419	Identity:	319/1419 - (22%)
Similarity:	474/1419 - (33%)	Gaps:	603/1419 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 GQFWYLITHDWWLSWMQYTQHTTHTCDYCKRTASQRTAVDEALVCDESFNTHSLEQHDSYSLGSG 466
            |..||||...|:..|.:|                         |..:|::.:::.:|:.:
Mouse    31 GAQWYLIDSRWFKQWKKY-------------------------VGFDSWDMYNVGEHNLF----- 65

  Fly   467 TGSASGSGSASSGISAGRHCGPVRPGPIDNSNLITANPFRNVRTLTGEGGHLKRDTPLVQNHDFE 531
                                    |||||||.|. ::|         |...||..  |:...|:.
Mouse    66 ------------------------PGPIDNSGLF-SDP---------ESQTLKEH--LIDELDYV 94

  Fly   532 LVPKSLWKALNRWYG---DNLPLPRQVIQPP--NSDVELELYPLNLRILLHQAQPSQTGVGGGTQ 591
            |||...|..|..|||   ...|:.|:|::..  ....::|:|.|.|: |...:.|
Mouse    95 LVPAEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELK-LCENSDP---------- 148

  Fly   592 LGSWGSTVSGGYGVLASGGGYAAIAVSSVLQPPKRYLAYTAAFSRLATVRQVGEFLCEQLRLKSE 656
                                      ::||         :..||:..|:..:.:.:.:...:.:|
Mouse   149 --------------------------TNVL---------SCHFSKADTIATIEKEMRKLFNIPAE 178

  Fly   657 -DIRLWH---------VPQLDNGAILLEEDAMCLKELLIRDNDQLLLEIRNKDLTWPEELGSL-- 709
             :.|||:         :.:|||          .:::..:.....|::|.:|:|.|||.:  ||
Mouse   179 RETRLWNKYMSNTYEQLSKLDN----------TIQDAGLYQGQVLVIEPQNEDGTWPRQ--SLQS 231

  Fly   710 -----------------ATAQCGQGAG--TPGDRRRLTRSSIM---------------------- 733
                             |:..|...|.  ..||.   |.||.|
Mouse   232 KSSTAPSRNFTTSSKPSASPYCSVSASLIANGDS---TNSSGMHSSGVSRGGSGFSASYNCQEPP 293

  Fly   734 SVH-APGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAEL 797
            |.| .||..||.|||||||||:|||.|.||.||.:||.::.:..|:|..|.||.||::|..||||
Mouse   294 SPHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTEYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 358

  Fly   798 LKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDS 862
            :|::|:.....|||...:..|.::||||:|..|.||||||.::||.||||||||.:|||.|.||:
Mouse   359 IKQMWSGRDTHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFILDGLHEDLNRVKKKPYLEPKDA 423

  Fly   863 NGRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIY 927
            |||||.:||.|||..|..||.|:|:|.|:|..||.:.|..|...||.||||..|:||||::....
Mouse   424 NGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRI 488

  Fly   928 FEVLVILLDGSV-PIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKL 991
            .||.::..|... ||:|...:......|.|...||.:..:....|:|.:::|.:..::...||.|
Mouse   489 MEVFLVPADPQCRPIQYRVTVPLMGAISDLCEALSKLSGIAAENMVVTDVYNHRFHKIFQMDEGL 553

  Fly   992 RTQSAK-ELYVYQLPEQSMRTRSNSGLSMHI-EQGLKDIQRSSALITSAQDSLSSLSTLQTSSHR 1054
            ...:.: :::||::...||.......|.::. |:..:....||..:...|..|.|:     ..|:
Mouse   554 SHITPRDDIFVYEVCNTSMDGSECITLPVYFREKKSRPSSASSGAVLYGQPLLVSV-----PKHK 613

  Fly  1055 ASSRVLCNGHVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSR 1119
            .:...|..                  :.|:..|.|                :.:.||||
Mouse   614 LTLESLYQ------------------AVCDRISRY----------------IKQPLPDE------ 638

  Fly  1120 CFGKRECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENS 1184
                               .|||..|....:|:.:..:.....::.|.|.....:|....|||
Mouse   639 -------------------FLSSPLEPGACNGSRSSYEGDEEEEMDHQEEGKEQLSEVEGSGE-- 682

  Fly  1185 MESSLTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHD 1249
                                                                |:|     .:||.
Mouse   683 ----------------------------------------------------DDQ-----GDDHS 690

  Fly  1250 QPDQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPN 1314
            :..|....||.
Mouse   691 ESAQKVKGQPR------------------------------------------------------ 701

  Fly  1315 SEGGTHKDLYCAVWLQVSRLLSPLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWS 1379
                 ||.|                                     ||...|.:.|..
Mouse   702 -----HKRL-------------------------------------FTFSLVNSCGTA------- 717

  Fly  1380 SFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTTKY 1444
                                 .||:.|::....|:|::
Mouse   718 ---------------------DINSLATDGKLLKLNSR--------------------------- 734

  Fly  1445 FEDFTIAIDWDPTALHLRYQSTLERLWVD--------------HETIAISRREQVEPVDLNHCLR 1495
               .|:|||||         |....|:.|              |.:::..::::...|.|..|:.
Mouse   735 ---STLAIDWD---------SETRSLYFDEQESECFSPQACEKHLSMSQPQKKKKAAVALRECIE 787

  Fly  1496 AFTSEEKL---EQWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKW-VKSQKVVHFPF 1556
            .||:.|.|   :.|| |..||..:.||||..:|.||.||:||||||: .|..| .|...||.||
Mouse   788 LFTTMETLGEHDPWY-CPTCKKHQQATKKFDLWSLPKILVVHLKRFS-YNRYWRDKLDTVVEFP- 849

  Fly  1557 DDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTK 1621
                             :|...:.|...|
Mouse   850 -----------------VRALNMSEFVCD------------------------------------ 861

  Fly  1622 ATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYAV 1686
                                 |..|         |.|                      |.|.||
Mouse   862 ---------------------RSAR---------PYV----------------------YDLIAV 874

  Fly  1687 VSHSGMLNGGHYISYASN-ATGSWYCYNDSSCREISQKPVIDPSAAYLLFYERK 1739
            .:|.|.:..|||.:||.| ..|.||.::|||....|:..:: ..|||:|||:|:
Mouse   875 SNHYGAMGVGHYTAYAKNRLNGKWYYFDDSSVSLASEDQIV-TKAAYVLFYQRR 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	181/576 (31%)
		Peptidase_C19	<1480..1737	CDD:351799	65/261 (25%)
Usp4	XP_006511759.1	UBP12	35..927	CDD:227847	316/1413 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920