Protein Alignment Usp32 and math-33

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001294689.1
• Gene: math-33 / 179538
• WormBaseID: WBGene00010406
• Length: 1138
• Species: Caenorhabditis elegans
• Alignment Length: 1122
• Identity: 219/1122 - (19%)
• Similarity: 357/1122 - (31%)
• Gaps: 395/1122 - (35%)

  Fly   661 WHVPQLDNGAILLEE-DAMCLKELLIRDNDQLLLEIRNKDLTWPEELGSLATAQCGQGAGTPGDR 724
            :|..::|.|....:: |.:|..:.....||.:.|..|             .||....||....|.
 Worm   138 FHNTEVDWGFSNYDQYDTLCNPKDGYVVNDTIKLRCR-------------FTADVPTGANYMWDS 189

  Fly   725 RRLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEV----NAANKLG 785
            :|.|          |..||.|.|.||:||:.||..:.|..    |:|.::..:|    |.:|.:
 Worm   190 KRHT----------GCIGLRNQGATCYMNSILQSFYFTTG----FRRAVYNMDVGTEPNESNIV- 239

  Fly   786 TKGQLAMR--YAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDL 848
                |||:  :.||........|.|   |...|..:|    .....|||.||....|||.|...:
 Worm   240 ----LAMQRVFYELQMASEAVETNS---LTRAFGWDK----LDAFNQHDVQEFCRVLLDNLETKM 293

  Fly   849 NRVMEKPYSELKDSNGRPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPF 913
                 |..||.|.                        |.:||.|.:||.:.||...:||.|.:.|
 Worm   294 -----KGTSEEKS------------------------IPNLFRGNMKSYIKCLDVDYESSRTESF 329

  Fly   914 --------SLLSLPLPVENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSHLKHKLS------TMC 964
                    .:.||....|.|...|:                |:.:.||....|.|.      ...
 Worm   330 YDVQLNVLGMDSLERAFEAYTTSEI----------------LDDENKYDAGDHGLQRAEKGVKFV 378

  Fly   965 SLPPNLMLVCELWNSQ---IRQVLND----DEKLRTQSAKELYVYQLPEQSMRTRSNSGLSMHIE 1022
            .|||  :|..:|...|   :.|.:|:    .||:...|..||       ..|.|..:...|:|
 Worm   379 ELPP--ILHVQLMRFQYCGVEQKINERFSFPEKMNLASCCEL-------GPMLTEEDCVYSLH-- 432

  Fly  1023 QGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCNGHVSGLDVEGEAE-VGTDVSQCNSN 1086
                     :.|:.|.:.......|.          :..|.|.|.:|....|: ...|....:..
 Worm   433 ---------AVLVHSGEFHGGHYVTY----------INVNLHESAVDPTSSAKWCKFDDDVVSRT 478

  Fly  1087 SNYNPIVSTYSG----NGSG-------DNQVHELL---PDE--AGKVSRCF------GKRE---- 1125
            :..:.|||.:.|    |.|.       ||.:.:.|   ||.  ...|||.|      ..||
 Worm   479 TTDDAIVSNFGGEKTMNSSAYMLVYVRDNAIDQFLAPIPDSQIPQSVSRTFEMERLHRNREKKKL 543

  Fly  1126 -----CM------------PHSLFCFKESLILSSSPENT------------FMHGAAAQQKRVSS 1161
                 ||            .||.....:|::..|.|..|            |:|....::..:..
 Worm   544 EEEQLCMGIVLVTPDIVASNHSFDLVDQSIVHDSIPHETVWKHMFTAELYQFVHDRLFEKSAMQK 608

  Fly  1162 AKLLHTESNTSSMSYTNHSGENSMESS-----LTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDS 1221
            ..:..::.........|.....|.:.:     :|:...|.                  ||:...:
 Worm   609 IDMFDSDDEARQARRDNLRRIKSKKFNFRLWRMTDSYSLE------------------RTTQKLT 655

  Fly  1222 SGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHR 1286
            |.|.....:....|.             :.|.:.:...||   :|...|:.           :.|
 Worm   656 SRLRPSEFIDCKTDT-------------RLDTLLSQDFET---IYVEFSNN-----------IER 693

  Fly  1287 KITRHDS-----YFLSYHKTRPSLFGVPLLIPNSEGGTHK--DLYCAVWLQVSRLLSPLPATTE- 1343
            .:..:|:     :|:.|:.|....|   .:|.::....||  :||.::..:    :..|||.||
 Worm   694 PLCEYDTARDLLFFVKYYDTMTDKF---TIIGHTMFDCHKRFNLYRSMLCE----MIGLPADTEL 751

  Fly  1344 --QANHAADCDDSLGYDFPFTL-RAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAA 1405
              ...|||...:.:.....::: |.|:..                          .|.:..:...
 Worm   752 KYYMEHAASYLELVDLTQNYSIGRLVEEQ--------------------------DGGILVVEKV 790

  Fly  1406 ASNTST----PKMNAKFPSLPNLEAKRTPEYTASL-SYTPTTKYFEDFTIAIDWDPTALHLRYQS 1465
            .::|||    .|||..|     |:.:  .|:..|. :..|..:.||.|
 Worm   791 ETSTSTQNAKQKMNELF-----LDVE--VEFVQSFYNKKPEEEPFEQF----------------- 831

  Fly  1466 TLERLWVDHE--TIA--ISRREQVEPVDLNHCLRAFTSEEKLEQW---YHCSHCKG--KKP---- 1517
             ::|:.:|.:  |:|  |..|..|:|..:....|  .|..:.|.:   |..:.|||  .:|
 Worm   832 -VKRICLDDKLFTVAEEIGARLNVDPKKVLIWTR--VSGSRFEPFFDDYMLNTCKGLMTRPVHDP 893

  Fly  1518 -ATKKLQI----------------------WKLPPILIVHLKRFNCVNGKWVK--SQKVVHFPFD 1557
             |.|:.::                      |:||...:..|..|....|..:.  ::...::||.
 Worm   894 RAYKRYRVQYAIMPFDIDEISKHRIQTKLFWQLPNGHVEELTLFPLKEGTVIDIINEAKRYYPFV 958

  Fly  1558 D------------------------FDPTPYLASVPQETILR-------HKELLELKNDAEMTMA 1591
            :                        :.....::.:.|.|:.:       |..|.|:..| |:.|:
 Worm   959 EGGSGKFRLLQIGAPPLSNQRVYQIYGENTLISDLDQRTMYKLVSSQALHCRLEEVPID-ELDMS 1022

  Fly  1592 TNEVVSELDEID-APSK 1607
            ..|.:..:...| .|:|
 Worm  1023 PGEFLCPVVHFDREPTK 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	91/368 (25%)
		Peptidase_C19	<1480..1737	CDD:470612	33/194 (17%)
math-33	NP_001294689.1	MATH	30..182	CDD:445786	11/56 (20%)
		peptidase_C19C	194..507	CDD:239124	94/403 (23%)
		USP7_ICP0_bdg	682..863	CDD:463580	47/252 (19%)
		USP7_C2	900..1125	CDD:464201	20/141 (14%)