DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp32 and H34C03.2

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001293696.1	Gene:	H34C03.2 / 177437	WormBaseID:	WBGene00019259	Length:	980	Species:	Caenorhabditis elegans

Alignment Length:	1485	Identity:	302/1485 - (20%)
Similarity:	453/1485 - (30%)	Gaps:	645/1485 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 GLWPQCKHMENDIVRGWLRREERRPYRVGQFWYLITHDWWLSWMQYTQHTTHTCDYCKRTASQRT 438
            |...:.|....::::..|...|.......:.||||:..||.|.::
Worm    20 GSQDESKTPSREVLKKLLNEVEMAEMEENEMWYLISQKWWNSLIK-------------------- 64

  Fly   439 AVDEALVCDESFNTHSLEQHDSYSLGSGTGSASGSGSASSGISAGRHCGPVRPGPIDNSNLITAN 503
            ||.:..|.|                                           .||||||.:   :
Worm    65 AVRDGFVDD-------------------------------------------VGPIDNSQI---S 83

  Fly   504 PFRNVRTLTGEGGHLKRDTPLVQNHDFELVPKSLWKALNRWY---GDNLP-LPRQVIQPPNSDVE 564
            ..||        |.......|.:..|:..||:.|:|.|.|:|   .|... :.|:|:: .:..:.
Worm    84 ECRN--------GSFFLKQRLAEQVDYTPVPEILFKRLERFYHIDDDRRDYIQRRVVR-KDGKLC 139

  Fly   565 LELYPLNLRILLHQ---------AQPSQTGVG------GGTQLGSWGSTVSGGYGVLASGGGYAA 614
            :|:||..:.|...:         .:|..|.|.      |...|    ||.......:.:|..|..
Worm   140 IEVYPRIVHITSARNRDIKADLVLRPDDTMVSLRERVIGELSL----STTDNIRFYVMNGENYEL 200

  Fly   615 IAVSSVLQPPKRYLAYTAAFSRLAT-VRQVGEFLCEQLRLKSEDIRLWHVPQLDNGAILLEEDAM 678
            |..:..:.      :|.....::.. |.:.|||.   ::.||.      .|:...|......|:.
Worm   201 IDTAQSID------SYFDTVQKVVVDVEEDGEFF---IKGKSA------TPKSLFGTQSSSSDSE 250

  Fly   679 CLKELLIR-----------------DNDQLLLEIRNKDLT-----------WPEEL--------- 706
            ...|.::|                 .:.:|||.:....|:           ||:.:
Worm   251 DDVENVVRLPKPNRHRQFSTSTVSSTSSKLLLPLWAVWLSFREAWWGFSQLWPDTIREAVAFLFG 315

  Fly   707 ------GSLATAQCGQGA----GTPGDRRRLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFN 761
                  .|.::...|.|.    .:|.     ..:.:::...|||.||.||||||||.:|.|.|.|
Worm   316 WWILRPPSYSSRHGGNGISNSYNSPS-----PSTGVVTRTTPGACGLSNLGNTCFMASAFQCLSN 375

  Fly   762 TQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFA 826
            ..||.:||....::.::|..|.|||.|.|||...||:|.:|:....|:.|.|.:..:.::||:|.
Worm   376 MPPLREYFLANTYQNDINEDNPLGTHGHLAMAVGELMKGMWSGDYASINPRKFKSIIGQFAPRFN 440

  Fly   827 GGGQHDSQELLEWLLDALHEDLNRVMEKPYSELKDSNGR-PDKIVAAEAWSQHHARNQSIIIDLF 890
            |..|.|:.||:.::||.|||||||:.:|||.|..|.:.: |:...||::|..:..||.|||:|..
Worm   441 GYSQQDAHELMAYVLDGLHEDLNRIKKKPYIEDSDEDAKLPEAEYAAKSWEVYKMRNDSIIVDTL 505

  Fly   891 YGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILLDGSVPIKYGFRLNSDCKYSH 955
            :|||||.:.|..|...|::||||..||||||.:..|..:.::::          |......|:|
Worm   506 HGQLKSTLICPVCEKISIKFDPFGYLSLPLPPKEQIVKQTVIVM----------FLTRKWAKFS- 559

  Fly   956 LKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLRTQSAKELYVYQLPEQSMRTRSNSGLSMH 1020
            |....:|.......|||                :||:.:.......:.:|.|
Worm   560 LGITDTTTVEEAERLML----------------DKLQPEQQHHFVFFHVPSQ------------- 595

  Fly  1021 IEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCNG-HVSGLDVEGEAEV-GTDVSQC 1083
                             ..|.::.:        |...||...| .|...:||.:.:| ||.:...
Worm   596 -----------------YHDDITMM--------RPGDRVRMPGREVYVAEVEHDLQVKGTRLFVA 635

  Fly  1084 NSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCFGKRECMPHSLFCFKESLILSSSPENTF 1148
                 ||.|
Worm   636 -----YNRI-------------------------------------------------------- 639

  Fly  1149 MHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSMESSLTEPIPLADLEPVSSRNGSGGEDCS 1213
                    |.|.||.|        .|.|:
Worm   640 --------KLVRSASL--------PMIYS------------------------------------ 652

  Fly  1214 YRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTSQPETSSGVYSRRSSQPPHKAG 1278
                      |.||:.|          ..|...||                |:|
Worm   653 ----------LPTGYPL----------TRGFLNDH----------------VFS----------- 670

  Fly  1279 KYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPNSEGGTHKDLYCAVWLQVSRLLSPLPATTE 1343
                     .|:|  :|::           |..:....||...|
Worm   671 ---------TTKH--FFIN-----------PKAVAELGGGNSND--------------------- 692

  Fly  1344 QANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDYVLQGALPPINAAASN 1408
                    |||:                                                 :.||
Worm   693 --------DDSM-------------------------------------------------SGSN 700

  Fly  1409 TSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTTK------------YFEDFTIAIDWDPTALHL 1461
            ::..:...|....|       |..||||...||..            |.....|...|....:..
Worm   701 SADEREPYKLFVGP-------PGSTASLPIPPTDDPIPFPDENSHDIYSNFLQIVFQWKDLKIFN 758

  Fly  1462 RYQST--LERLWVDHETIAISRREQVEPVDLNHCLRAFTSEEKL---EQWYHCSHCKGKKPATKK 1521
            :|:..  :||     |....:||:    |.|...|..||::|:|   :.|| |..||..:.|||:
Worm   759 QYKGNELIER-----EMTVSTRRK----VLLQETLDWFTTKEQLGEQDSWY-CPQCKKHERATKQ 813

  Fly  1522 LQIWKLPPILIVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPYLASVPQETILRHKELLELKNDA 1586
            |.:||||.|||:|||||...  ||.:.:
Worm   814 LALWKLPEILILHLKRFQYT--KWSREK------------------------------------- 839

  Fly  1587 EMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTKATASPPPTGNILRQSKTKNAVRRQRLISTS 1651
                .|.|||..:..:|...|...   ||
Worm   840 ----LTWEVVIPVRGLDLTDKVAN---PN------------------------------------ 861

  Fly  1652 LTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYAVVSHSGMLNGGHYISYASN-ATGSWYCYNDS 1715
                          |:..:          |.|.||..|.|.|:||||.:...| ....|:.:|||
Worm   862 --------------HEKAI----------YDLIAVSRHYGSLSGGHYTAIGYNDREQKWFDFNDS 902

  Fly  1716 SCREISQKPVIDP---SAAYLLFYERKGLDY--EPYLPNIEGRTL---PNTASVP 1762
            |..  ...|..:|   |..|:|.|.|:.||.  :|..|:....:|   |...:.|
Worm   903 SAN--PTYPPAEPYESSDPYILVYRRRKLDSNGKPIEPSAVSESLHSRPKRGAAP 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	155/583 (27%)
		Peptidase_C19	<1480..1737	CDD:351799	63/263 (24%)
H34C03.2	NP_001293696.1	DUSP	51..135	CDD:197831	32/158 (20%)
		Peptidase_C19	356..>583	CDD:271592	95/253 (38%)
		Peptidase_C19	<777..925	CDD:271592	61/260 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920