Protein Alignment Usp32 and Usp33

DIOPT Version :10

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_573510.2
• Gene: Usp33 / 170822
• MGIID: 2159711
• Length: 909
• Species: Mus musculus
• Alignment Length: 1041
• Identity: 182/1041 - (17%)
• Similarity: 275/1041 - (26%)
• Gaps: 507/1041 - (48%)

  Fly   737 APGATGLHNLGNTCFMNAALQVLFNTQPLAQYFQREMHRFEVNAANKLGTKGQLAMRYAELLKEV 801
            |.|.|||.|:||||:||||||.|.|..||.|:|      .:.....:...|..:...|.:|:.|:
Mouse   150 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFF------LDCGGLARTDKKPAICKSYLKLMTEL 208

  Fly   802 W-TATTRSVAPLKLRFCVNKYAPQFAGGGQHDSQELLEWLLDALHEDL-NRVMEKPYSELKDSNG 864
            | .:...||.|..|...:....|.|.|..|.|:||.|..|:|.|||:| .:|||        ...
Mouse   209 WHKSRPGSVVPANLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVME--------MEE 265

  Fly   865 RPDKIVAAEAWSQHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFE 929
            .|..:.:.|...:..:::.   :|.        .||..|
Mouse   266 EPQTLTSEETVEEEKSQSD---VDF--------QSCESC-------------------------- 293

  Fly   930 VLVILLDGSVPIKYGFRLNSDCKYSHLKHKLSTMCSLPPNLMLVCELWNSQIRQVLNDDEKLRTQ 994
                                                                    :..||...:
Mouse   294 --------------------------------------------------------SSSEKAENE 302

  Fly   995 SAKELYVYQLPEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRV 1059
            |..:.:.....|.:|..:....|.|     .||.|:..
Mouse   303 SGSKGFPEDSNETTMLIQDEDDLEM-----AKDWQKEK--------------------------- 335

  Fly  1060 LCNG-HVSGLDVEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCFGK 1123
            :||. :.:..|||.:.:..|.....:.||                        .|..||.
Mouse   336 VCNKINKANADVELDKDRDTVCETVDLNS------------------------QETVKVQ----- 371

  Fly  1124 RECMPHSLFCFKESLILSSSPENTFMHGAAAQQKRVSSAKLLHTESNTSSMSYTNHSGENSMESS 1188
                                     :||.|::                                |
Mouse   372 -------------------------IHGRASE--------------------------------S 379

  Fly  1189 LTEPIPLADLEPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQ 1253
            :|: :.|.||                .||....|..|....|.||                 |.:
Mouse   380 ITD-VHLNDL----------------ATSQILPSNESVSPRLSAS-----------------PPK 410

  Fly  1254 ITTSQPETSSGVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPNSEGG 1318
            :.:..|..|          ||||..:...|..:|  :|.    .|......:|         :|.
Mouse   411 LGSLWPGLS----------PPHKKAQSTSAKRKK--QHK----KYRSVISDIF---------DGT 450

  Fly  1319 THKDLYCAVWLQVSRLLS-------PLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCAIC 1376
            ....:.|....:||..|.       |:|...:.|...:....::          |||..
Mouse   451 VISSVQCLTCDRVSITLETFQDLSLPIPGKEDLAKLHSSSHPTI----------VKAGS------ 499

  Fly  1377 PWSSFCRGCEIRCNNDYVLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPT 1441
                        |...|..||.:                |.|           .||......:..
Mouse   500 ------------CGEAYAPQGWI----------------AFF-----------MEYVKRFVVSCV 525

  Fly  1442 TKYFEDFTIAIDWDPTALHLRYQSTLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEEKL--E 1504
            ..:|        |.|.                              |.|..||.||.:.::|  :
Mouse   526 PSWF--------WGPV------------------------------VTLQDCLAAFFARDELKGD 552

  Fly  1505 QWYHCSHCKGKKPATKKLQIWKLPPILIVHLKRFNCVNGKWVKSQKV---VHFPFDDFDPTPYLA 1566
            ..|.|..||..:...|..::.|.|.||.:|||||   ..:.:.|.|:   |.||.:..|..|:||
Mouse   553 NMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRF---RHELMFSTKISTHVSFPLEGLDLQPFLA 614

  Fly  1567 SVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTKATASPPPTGN 1631
            .                                   |:|::.|
Mouse   615 K-----------------------------------DSPAQIV---------------------- 622

  Fly  1632 ILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYAVVSHSGMLNGG 1696
                                                            .|.|.:|:.|.|..:.|
Mouse   623 ------------------------------------------------TYDLLSVICHHGTASSG 639

  Fly  1697 HYISYA-SNATGSWYCYNDSSCREISQKPVIDPSAAYLLFYERKGLDYEPYLPNIEGRTLPNTAS 1760
            |||:|. :|....||.::|.|..|:|:. .:..:.||:|||.:...:.:.     |.|.:.|..:
Mouse   640 HYIAYCRNNLNNLWYEFDDQSVTEVSES-TVQNAEAYVLFYRKSSEEAQK-----ERRRISNLLN 698

  Fly  1761 V 1761
            :
Mouse   699 I 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	EFh_PI-PLC	198..>251	CDD:333715
		EF-hand motif	198..222	CDD:320029
		EF-hand_7	227..290	CDD:463900
		UBP12	486..>1002	CDD:227847	57/266 (21%)
		Peptidase_C19	<1480..1737	CDD:470612	54/262 (21%)
Usp33	NP_573510.2	zf-UBP	30..90	CDD:460464
		UCH	154..679	CDD:425685	175/1010 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..315		11/154 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..436		13/67 (19%)
		DUSP	701..770	CDD:416436
		DUSP	807..891	CDD:197831