Protein Alignment Usp32 and USP43

DIOPT Version :9

• Sequence 1: NP_001262074.2
• Gene: Usp32 / 40169
• FlyBaseID: FBgn0036913
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_694942.3
• Gene: USP43 / 124739
• HGNCID: 20072
• Length: 1123
• Species: Homo sapiens
• Alignment Length: 1065
• Identity: 217/1065 - (20%)
• Similarity: 328/1065 - (30%)
• Gaps: 456/1065 - (42%)

  Fly   714 CGQG-----AGTPGDRR------RLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFNTQPLAQ 767
            |..|     .|:||:.|      :|...:......|||.||.|.||||||||.:|.|.||..||:
Human    63 CAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAE 127

  Fly   768 YFQREMHRFEVNAANKLGTKGQLAMRYAELLKEVWTATTRSVAPLKLRFCVNKYAPQFAGGGQHD 832
            :.....:|.....|       ::..:.|.|::.:||.........:.:..|:||..||.|..|||
Human   128 FLALGRYRAAPGRA-------EVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHD 185

  Fly   833 SQELLEWLLDALHEDLNRVMEKPYSELKDSNGRPDKIVAAEAWSQHHAR---NQSIIIDLFYGQL 894
            :.|.|.||||.:||||......|.||...    |:....:|......|:   .||.:...|..|.
Human   186 ALEFLLWLLDRVHEDLEGSSRGPVSEKLP----PEATKTSENCLSPSAQLPLGQSFVQSHFQAQY 246

  Fly   895 KSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILLDGS---------VPIKYGFRLNSD 950
            :|.::|..|..:|..||||..:|||:|:....:..|.::....|         |||
Human   247 RSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPI--------- 302

  Fly   951 CKYSHLKHKLSTMCSL----------PPNLMLVCELWNSQIRQVLNDDEKLRT-QSAKELYVYQL 1004
                     |||:.:|          |.:.:::.||:.|..::...|:|.|.| .....:|.:|:
Human   303 ---------LSTVAALRKMVAEEGGVPADEVILVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQV 358

  Fly  1005 PEQSMRTRSNSGLSMHIEQGLKDIQRSSALITSAQDSLSSLSTLQTSSHRASSRVLCNGHVSGLD 1069
            |.                             :.:|.:||:.....::|.|.::|   .|....|.
Human   359 PP-----------------------------SPSQGTLSAHPLGLSASPRLAAR---EGQRFSLS 391

  Fly  1070 VEGEAEVGTDVSQCNSNSNYNPIVSTYSGNGSGDNQVHELLPDEAGKVSRCFGKRECMPHSLFCF 1134
            :..|::|  .:..||       :|      |||.            :.|| ||..       |..
Human   392 LHSESKV--LILFCN-------LV------GSGQ------------QASR-FGPP-------FLI 421

  Fly  1135 KESLILSSSPENTFMHGAAAQQKRVSSAK-LLHTESNTSSMSYTNHSGENSMESSLTEPIPLADL 1198
            :|...:|         .|..||..:|..: |:.:|:...::        .|:.|.....:.:|
Human   422 REDRAVS---------WAQLQQSILSKVRHLMKSEAPVQNL--------GSLFSIRVVGLSVA-- 467

  Fly  1199 EPVSSRNGSGGEDCSYRTSPNDSSGLSTGHTLGASLDVDEQAEEGNAEDHDQPDQITTSQPETSS 1263
                         ||| .||.||..|.                      |...|::
Human   468 -------------CSY-LSPKDSRPLC----------------------HWAVDRV--------- 487

  Fly  1264 GVYSRRSSQPPHKAGKYLVAVHRKITRHDSYFLSYHKTRPSLFGVPLLIPNSEGGTHKDLYCAVW 1328
             ::.||...|||.         :.....||      ..:..|||
Human   488 -LHLRRPGGPPHV---------KLAVEWDS------SVKERLFG--------------------- 515

  Fly  1329 LQVSRLLSPLPATTEQANHAADCDDSLGYDFPFTLRAVKADGLTCAICPWSSFCRGCEIRCNNDY 1393
                         :.|...|.|.|..
Human   516 -------------SLQEERAQDADSV--------------------------------------- 528

  Fly  1394 VLQGALPPINAAASNTSTPKMNAKFPSLPNLEAKRTPEYTASLSYTPTTKYFEDFTIAIDWDPTA 1458
                                                                        |....
Human   529 ------------------------------------------------------------WQQQQ 533

  Fly  1459 LHLRYQSTLERLWVDHETIAISRREQVEPVDLNHCLRAFTSEEKLEQ---WYHCSHCKGKKPATK 1520
            .|.::..||:                       .|.:.:|.||:|.|   | .|.||:..:....
Human   534 AHQQHSCTLD-----------------------ECFQFYTKEEQLAQDDAW-KCPHCQVLQQGMV 574

  Fly  1521 KLQIWKLPPILIVHLKRFNCVNGKWVKSQKVVHFPFDDFDPTPYLASVPQETILRHKELLELKND 1585
            ||.:|.||.|||:|||||..|..:..|...:|.||....:..|::|
Human   575 KLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA------------------- 620

  Fly  1586 AEMTMATNEVVSELDEIDAPSKEVKEELPNQTGSTKATASPPPTGNILRQSKTKNAVRRQRLIST 1650
                                         .::.|.:|...|.|:
Human   621 -----------------------------QRSTSPEAGLGPWPS--------------------- 635

  Fly  1651 SLTKTPIVDGEFEDYHQHRLKPDVDQFDPRYRLYAVVSHSGMLNGGHYISYASNA-TGSWYCYND 1714
                          :.|....|.....|..|.||||.:|.|.|.||||.:|..|: .|.||.|:|
Human   636 --------------WKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDD 686

  Fly  1715 SSCREISQKPVIDPSAAYLLFYERK 1739
            |:...:.:..| :...||:|||:::
Human   687 STVEPLREDEV-NTRGAYILFYQKR 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	92/321 (29%)
		Peptidase_C19	<1480..1737	CDD:351799	62/260 (24%)
USP43	NP_694942.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..102		10/38 (26%)
		DUF3628	<36..>107	CDD:289100	13/43 (30%)
		Peptidase_C19	<98..>210	CDD:271592	46/118 (39%)
		Peptidase_C19	102..>284	CDD:271592	65/192 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..221		4/22 (18%)
		Peptidase_C19R	<540..708	CDD:239139	64/275 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	795..826
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	854..886
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	959..1049
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1068..1099

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920