| Sequence 1: | NP_001262074.2 | Gene: | Usp32 / 40169 | FlyBaseID: | FBgn0036913 | Length: | 1779 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_059110.2 | Gene: | USP18 / 11274 | HGNCID: | 12616 | Length: | 372 | Species: | Homo sapiens |
| Alignment Length: | 262 | Identity: | 57/262 - (21%) |
|---|---|---|---|
| Similarity: | 89/262 - (33%) | Gaps: | 119/262 - (45%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1489 DLNHCL---RAFTSEEKLEQWYHCSHCKGKKPATKK-LQIWKLPPILIVHLKRFNCVNGKWVKSQ 1549
Fly 1550 KVVHFPFDDFDPTPYLASVPQETILRHKELLELKNDAEMTMATNEVVSELDEIDAPSKEVKEELP 1614
Fly 1615 NQTGSTKATASPPPTGNILRQSKTKNAVRRQRLISTSLTKTPIVDGEFEDYHQHRLKPDVDQFDP 1679
Fly 1680 RYRLYAVVSHSGMLNGGHYISYASNAT-GSWYCYNDSSCREISQKPVI----DPS-----AAYLL 1734
Fly 1735 FY 1736 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Usp32 | NP_001262074.2 | EFh_PI-PLC | 198..>251 | CDD:333715 | |
| EF-hand motif | 198..222 | CDD:320029 | |||
| EF-hand_7 | 227..290 | CDD:463900 | |||
| UBP12 | 486..>1002 | CDD:227847 | |||
| Peptidase_C19 | <1480..1737 | CDD:470612 | 57/262 (22%) | ||
| USP18 | NP_059110.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 19..45 | ||
| Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510 | 36..51 | ||||
| Mediates interaction with STAT2. /evidence=ECO:0000269|PubMed:28165510 | 51..112 | ||||
| UCH | 55..367 | CDD:425685 | 56/260 (22%) | ||
| Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000269|PubMed:28165510 | 303..312 | 4/8 (50%) | |||
| Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510 | 313..372 | 20/55 (36%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||