DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab8 and SEC4

DIOPT Version :9

Sequence 1:	NP_001246837.1	Gene:	Rab8 / 40168	FlyBaseID:	FBgn0262518	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_116650.1	Gene:	SEC4 / 850543	SGDID:	S000001889	Length:	215	Species:	Saccharomyces cerevisiae

Alignment Length:	204	Identity:	108/204 - (52%)
Similarity:	150/204 - (73%)	Gaps:	6/204 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQ 67
            |:||.:.|:||||||||||:|:|.||.||.||.:||:||||||||:|::::.||:|||:||||||
Yeast    15 KSYDSIMKILLIGDSGVGKSCLLVRFVEDKFNPSFITTIGIDFKIKTVDINGKKVKLQLWDTAGQ 79

  Fly    68 ERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVS 132
            |||||||||||||||||:||||:|.|::|.|||.|.:.:.|:|:.:.:.:|:|||.:: :.|.|:
Yeast    80 ERFRTITTAYYRGAMGIILVYDVTDERTFTNIKQWFKTVNEHANDEAQLLLVGNKSDM-ETRVVT 143

  Fly   133 KERGEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAK--TEKRMEANNPPKGGHQLKPMDSR 195
            .::||.||.|.||.|:|:|||...||.|.|.|||..|:.|  :.|.:...|..:|...:   :|.
Yeast   144 ADQGEALAKELGIPFIESSAKNDDNVNEIFFTLAKLIQEKIDSNKLVGVGNGKEGNISI---NSG 205

  Fly   196 TKDSWLSRC 204
            :.:|..|.|
Yeast   206 SGNSSKSNC 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_001246837.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	98/165 (59%)
SEC4	NP_116650.1	Rab8_Rab10_Rab13_like	18..183	CDD:206659	98/165 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I520
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100934
Inparanoid	1	1.050	217	1.000	Inparanoid score	I784
Isobase	1	0.950	-	0	Normalized mean entropy	S199
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000502
OrthoInspector	1	1.000	-	-		otm46519
orthoMCL	1	0.900	-	-		OOG6_101252
Panther	1	1.100	-	-	LDO	PTHR47980
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1998
SonicParanoid	1	1.000	-	-		X312
TreeFam	0	0.000	Not matched by this tool.
	13	12.840