DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab8 and CRACR2A

DIOPT Version :9

Sequence 1:	NP_001246837.1	Gene:	Rab8 / 40168	FlyBaseID:	FBgn0262518	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	XP_006719084.1	Gene:	CRACR2A / 84766	HGNCID:	28657	Length:	732	Species:	Homo sapiens

Alignment Length:	183	Identity:	74/183 - (40%)
Similarity:	120/183 - (65%)	Gaps:	4/183 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQERF 70
            |.|||::.:|:|.||||..|.||.||.|:....:|:|||::::|:.:||.::.||:||||||||:
Human   544 DRLFKIVFVGNSAVGKTSFLRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERY 608

  Fly    71 RTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVSKER 135
            |.||..::|.|.|::::||:|.::||.:::.|:.::||.....|..:|||||.:...:|:|.:..
Human   609 RCITQQFFRKADGVIVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLDNEKEREVPRGL 673

  Fly   136 GEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAK----TEKRMEANNPPK 184
            |||||.|..:.|.|.||.:..|.:|:.|.||..:|.:    .|..::..:|.|
Human   674 GEQLATENNLIFYECSAYSGHNTKESLLHLARFLKEQEDTVREDTIQVGHPAK 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_001246837.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	71/165 (43%)
CRACR2A	XP_006719084.1	EFh	54..114	CDD:298682
		EF-hand_7	55..109	CDD:290234
		RILP-like	<226..313	CDD:304877
		RAB	547..710	CDD:197555	69/162 (43%)
		Rab	547..705	CDD:206640	67/157 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900