DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab8 and Rab1b

DIOPT Version :9

Sequence 1:	NP_001246837.1	Gene:	Rab8 / 40168	FlyBaseID:	FBgn0262518	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_083852.1	Gene:	Rab1b / 76308	MGIID:	1923558	Length:	201	Species:	Mus musculus

Alignment Length:	177	Identity:	105/177 - (59%)
Similarity:	140/177 - (79%)	Gaps:	4/177 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTA 65
            |...|||||||||||||||||:|:|.||::|.:..::|||||:||||||||||.|.|||||||||
Mouse     1 MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTA 65

  Fly    66 GQERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQ 130
            |||||||||::|||||.||::|||:|.::|:.|:|.|::.|:..||.:|.|:|:|||.:||.|:.
Mouse    66 GQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKV 130

  Fly   131 VSKERGEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTEKRM 177
            |.....::.|...|:.|:|||||.:.|||:||:|:|::||    |||
Mouse   131 VDNTTAKEFADSLGVPFLETSAKNATNVEQAFMTMAAEIK----KRM 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_001246837.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	100/165 (61%)
Rab1b	NP_083852.1	Rab1_Ypt1	7..172	CDD:206661	99/168 (59%)
		Effector region. /evidence=ECO:0000255	37..45		5/7 (71%)
		Switch 2 region, required for interaction with REP1/CHM. /evidence=ECO:0000250\|UniProtKB:Q9H0U4	64..83		16/18 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..201		105/177 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910