Protein Alignment Rab8 and RAB27B

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_004154.2
• Gene: RAB27B / 5874
• HGNCID: 9767
• Length: 218
• Species: Homo sapiens
• Alignment Length: 199
• Identity: 86/199 - (43%)
• Similarity: 134/199 - (67%)
• Gaps: 18/199 - (9%)

  Fly     5 YDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNK----------KIKL 59
            ||||.|||.:||||||||..|:|::::.||..||:|:||||:.:.:..:.:          |:.|
Human     6 YDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGKAFKVHL 70

  Fly    60 QIWDTAGQERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENA---SADVEKMLLGN 121
            |:||||||||||::|||::|.|||.:|::|:|.::||.|::||:..::.||   :.|:  :|:||
Human    71 QLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDI--VLIGN 133

  Fly   122 KCELTDKRQVSKERGEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTEKRMEANNPP--- 183
            |.:|.|:|:|::.:..:||.:|||.:.||||....|||:|..||...|..:.|:.:|....|
Human   134 KADLPDQREVNERQARELADKYGIPYFETSAATGQNVEKAVETLLDLIMKRMEQCVEKTQIPDTV 198

  Fly   184 KGGH 187
            .||:
Human   199 NGGN 202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	80/178 (45%)
RAB27B	NP_004154.2	Rab27A	6..185	CDD:206700	81/180 (45%)
		Effector region. /evidence=ECO:0000250	38..46		5/7 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..218		3/9 (33%)