Protein Alignment Rab8 and RAB6A

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_002860.2
• Gene: RAB6A / 5870
• HGNCID: 9786
• Length: 208
• Species: Homo sapiens
• Alignment Length: 159
• Identity: 75/159 - (47%)
• Similarity: 110/159 - (69%)
• Gaps: 0/159 - (0%)

  Fly     9 FKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQERFRTI 73
            |||:.:|:..||||.::.||..|:|:.|:.:||||||..:|:.|:::.|:||:||||||||||::
Human    14 FKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSL 78

  Fly    74 TTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVSKERGEQ 138
            ..:|.|.:...::|||||...||:....||.::.....:||..||:|||.:|.||||||.|.||:
Human    79 IPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGER 143

  Fly   139 LAIEYGIKFMETSAKASINVEEAFLTLAS 167
            .|.|..:.|:||||||..||::.|..:|:
Human   144 KAKELNVMFIETSAKAGYNVKQLFRRVAA 172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	75/159 (47%)
RAB6A	NP_002860.2	Rab6	14..174	CDD:206654	75/159 (47%)
		Switch 1. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	32..50		9/17 (53%)
		Switch 2. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	69..88		10/18 (56%)