Protein Alignment Rab8 and RAB5A

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_004153.2
• Gene: RAB5A / 5868
• HGNCID: 9783
• Length: 215
• Species: Homo sapiens
• Alignment Length: 178
• Identity: 74/178 - (41%)
• Similarity: 110/178 - (61%)
• Gaps: 8/178 - (4%)

  Fly     9 FKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQERFRTI 73
            |||:|:|:|.|||:.::.||.:..|:....||||..|..:|:.||:..:|.:|||||||||:.::
Human    21 FKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSL 85

  Fly    74 TTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVSKERGEQ 138
            ...|||||...::|||||.|:||...|||::.::..||.::...|.|||.:|.:||.|..:..:.
Human    86 APMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQS 150

  Fly   139 LAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTEKRMEANNPPKGG 186
            .|.:..:.|||||||.|:||.|.|:.:|        |::..|.|...|
Human   151 YADDNSLLFMETSAKTSMNVNEIFMAIA--------KKLPKNEPQNPG 190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	70/162 (43%)
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	71/168 (42%)
		Switch 1. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	44..56		5/11 (45%)
		Switch 2. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	77..93		8/15 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..215		3/10 (30%)