DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab8 and cracr2ab

DIOPT Version :9

Sequence 1:	NP_001246837.1	Gene:	Rab8 / 40168	FlyBaseID:	FBgn0262518	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	XP_009298523.1	Gene:	cracr2ab / 564347	ZFINID:	ZDB-GENE-041210-94	Length:	773	Species:	Danio rerio

Alignment Length:	183	Identity:	74/183 - (40%)
Similarity:	117/183 - (63%)	Gaps:	1/183 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQERFRT 72
            |||::|:|:|.||||.:|.||.:..|::...:|:|||:.:||:.|.:..:.||:||||||||:|:
Zfish   586 LFKVILVGNSSVGKTALLRRFCDGQFHSATSATVGIDYSVRTLNLGDSHVALQLWDTAGQERYRS 650

  Fly    73 ITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVSKERGE 137
            ||..::|.|.|::::||||.|.||.:::.|:.:|:|.....:..||||||.:..::|:|..:..:
Zfish   651 ITKQFFRKADGVVVIYDITMEDSFSSVRPWLSSIQEAVGDPIPVMLLGNKSDKENEREVQTKEAD 715

  Fly   138 QLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTEKRMEANNPPKGGHQLK 190
            .||.|..:.|.|.||....||.||.:.||..:: :.|.|:..|....|...||
Zfish   716 LLAEEANLMFYECSAYTGANVLEAMIHLARVLR-EQEDRVWVNTVRLGDQPLK 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_001246837.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	68/163 (42%)
cracr2ab	XP_009298523.1	EFh	46..106	CDD:238008
		EF-hand_7	47..98	CDD:290234
		FAM184	210..390	CDD:292293
		RAB	587..745	CDD:197555	66/157 (42%)
		Rab	587..745	CDD:206640	66/157 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810