DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab8 and RAB44

DIOPT Version :9

Sequence 1:	NP_001246837.1	Gene:	Rab8 / 40168	FlyBaseID:	FBgn0262518	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_001244286.1	Gene:	RAB44 / 401258	HGNCID:	21068	Length:	1021	Species:	Homo sapiens

Alignment Length:	185	Identity:	74/185 - (40%)
Similarity:	117/185 - (63%)	Gaps:	6/185 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQERF 70
            ||||.::.:|||.||||..|....:::|.|...:|:|:||:::|:.:|||...||:||||||||:
Human   831 DYLFHVIFLGDSNVGKTSFLHLLHQNSFATGLTATVGVDFRVKTLLVDNKCFVLQLWDTAGQERY 895

  Fly    71 RTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVSKER 135
            .::|....|.|.|::|:||||.::||.:::.|:..:::..|..|..:|||||.:..::||||.|.
Human   896 HSMTRQLLRKADGVVLMYDITSQESFAHVRYWLDCLQDAGSDGVVILLLGNKMDCEEERQVSVEA 960

  Fly   136 GEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTE------KRMEANNPPK 184
            |:|||.|.|:.|.|.||....|:.|..:.||..::.:.|      .::....|||
Human   961 GQQLAQELGVYFGECSAALGHNILEPVVNLARSLRMQEEGLKDSLVKVAPKRPPK 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_001246837.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	70/165 (42%)
RAB44	NP_001244286.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		EF-hand_8	59..102	CDD:316358
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..133
		SMC_N	<191..>337	CDD:330553
		Atrophin-1	<326..647	CDD:331285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..405
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..483
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..827
		DNA_pol3_gamma3	<523..831	CDD:331207	74/185 (40%)
		Rab	834..992	CDD:206640	66/157 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810