Protein Alignment Rab8 and RAB15

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_001295083.1
• Gene: RAB15 / 376267
• HGNCID: 20150
• Length: 212
• Species: Homo sapiens
• Alignment Length: 217
• Identity: 106/217 - (48%)
• Similarity: 150/217 - (69%)
• Gaps: 23/217 - (10%)

  Fly     1 MAKTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTA 65
            |||.||.||:|||||||||||||:|.||:::.|:::.|||||:|||::|||:|..|:::||||||
Human     1 MAKQYDVLFRLLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVDFKMKTIEVDGIKVRIQIWDTA 65

  Fly    66 GQERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQ 130
            ||||::|||..|||.|.||.|||||:.|:|:::|..|:.:::|.|...|:|:|:|||.:...|||
Human    66 GQERYQTITKQYYRRAQGIFLVYDISSERSYQHIMKWVSDVDEYAPEGVQKILIGNKADEEQKRQ 130

  Fly   131 VSKERGEQLAIEYGIKFMETSAKASINVEEAF-----LTLASDIKAKTEKRMEANN--------- 181
            |.:|:|:|||.|||:.|.||||..::|::|:|     |.|.:..|.....||.|:|
Human   131 VGREQGQQLAKEYGMDFYETSACTNLNIKESFTRLTELVLQAHRKELEGLRMRASNELALAELEE 195

  Fly   182 ---PPKGGHQLKPMDSRTKDSW 200
               .|:|     |.:| :|..|
Human   196 EEGKPEG-----PANS-SKTCW 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	92/170 (54%)
RAB15	NP_001295083.1	Rab15	9..172	CDD:206698	89/162 (55%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	31..45		6/13 (46%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	63..80		12/16 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..212		6/25 (24%)