DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab8 and Rab40

DIOPT Version :9

Sequence 1:	NP_001246837.1	Gene:	Rab8 / 40168	FlyBaseID:	FBgn0262518	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_727611.1	Gene:	Rab40 / 32195	FlyBaseID:	FBgn0030391	Length:	265	Species:	Drosophila melanogaster

Alignment Length:	176	Identity:	74/176 - (42%)
Similarity:	105/176 - (59%)	Gaps:	13/176 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGID----------FKIRTIELDNK 55
            |.|.||||.|:||:|||.|||..||....:.:..:.|.|  |.|          :|..||.|:.|
  Fly     4 MTKDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCS--GNDCTSHILQTVAYKTTTILLEGK 66

  Fly    56 KIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLG 120
            ::|||:|||:||.||.||..:|.|||.||:||||||.:.||:.|..|::.::|:|.. :.|:|:|
  Fly    67 RVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHAPG-IPKVLVG 130

  Fly   121 NKCELTDKRQVSKERGEQLAIEYGIKFMETSAKASINVEEAFLTLA 166
            |:..|..||||:.::.|..|....:...|.|...:.|:.|:|..||
  Fly   131 NRLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELA 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_001246837.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	71/171 (42%)
Rab40	NP_727611.1	P-loop_NTPase	6..265	CDD:304359	73/174 (42%)
		RAB	12..182	CDD:197555	68/168 (40%)
		SOCS	192..234	CDD:295349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47980
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910