DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab8 and Rab12

DIOPT Version :9

Sequence 1:	NP_001246837.1	Gene:	Rab8 / 40168	FlyBaseID:	FBgn0262518	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_037149.1	Gene:	Rab12 / 25530	RGDID:	3527	Length:	243	Species:	Rattus norvegicus

Alignment Length:	168	Identity:	83/168 - (49%)
Similarity:	125/168 - (74%)	Gaps:	1/168 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQERF 70
            |:..::::||..|||||.::.||::|.|.....||:|:||||:|:||..|||:||||||||||||
  Rat    39 DFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERF 103

  Fly    71 RTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVSKER 135
            .:||:||||.|.||:||||||::::|:::..|::.|::.||.|.|.:|:|||.:....|::|:::
  Rat   104 NSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREISRQQ 168

  Fly   136 GEQLAIEY-GIKFMETSAKASINVEEAFLTLASDIKAK 172
            ||:.|.:. |::|.|.|||.:.||:|.||.|..||..|
  Rat   169 GEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKK 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_001246837.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	82/166 (49%)
Rab12	NP_037149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		Rab12	42..243	CDD:206699	82/165 (50%)
		Effector region. /evidence=ECO:0000250	70..78		3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47980
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910