DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab8 and Rab8a

DIOPT Version :9

Sequence 1:	NP_001246837.1	Gene:	Rab8 / 40168	FlyBaseID:	FBgn0262518	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_075615.2	Gene:	Rab8a / 17274	MGIID:	96960	Length:	207	Species:	Mus musculus

Alignment Length:	207	Identity:	165/207 - (79%)
Similarity:	185/207 - (89%)	Gaps:	0/207 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTA 65
            |||||||||||||||||||||||:||||||||||:||||||||||||||||||.|:|||||||||
Mouse     1 MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTA 65

  Fly    66 GQERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQ 130
            ||||||||||||||||||||||||||.||||:||:||||||||:||||||||:|||||::.||||
Mouse    66 GQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKRQ 130

  Fly   131 VSKERGEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTEKRMEANNPPKGGHQLKPMDSR 195
            |||||||:||::||||||||||||:||||.||.|||.|||||.:|::|.|:|....|.:|....:
Mouse   131 VSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSPQGSSHGVKITVEQ 195

  Fly   196 TKDSWLSRCSLL 207
            .|.:...|||||
Mouse   196 QKRTSFFRCSLL 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_001246837.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	146/165 (88%)
Rab8a	NP_075615.2	Rab8_Rab10_Rab13_like	6..172	CDD:206659	146/165 (88%)
Rab8a	NP_075615.2	Effector region. /evidence=ECO:0000250	37..45		7/7 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	291	1.000	Domainoid score	I1531
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100934
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2390
Isobase	1	0.950	-	0	Normalized mean entropy	S199
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1426655at2759
OrthoFinder	1	1.000	-	-		FOG0000502
OrthoInspector	1	1.000	-	-		otm42702
orthoMCL	1	0.900	-	-		OOG6_101252
Panther	1	1.100	-	-	LDO	PTHR47980
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1998
SonicParanoid	1	1.000	-	-		X312
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810