DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab8 and rab-8

DIOPT Version :9

Sequence 1:	NP_001246837.1	Gene:	Rab8 / 40168	FlyBaseID:	FBgn0262518	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_491199.2	Gene:	rab-8 / 171935	WormBaseID:	WBGene00004272	Length:	211	Species:	Caenorhabditis elegans

Alignment Length:	215	Identity:	153/215 - (71%)
Similarity:	182/215 - (84%)	Gaps:	12/215 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTA 65
            |||||||||||||||||||||||:|||||:|:||.:|||||||||||||||||.|||||||||||
Worm     1 MAKTYDYLFKLLLIGDSGVGKTCVLFRFSDDSFNNSFISTIGIDFKIRTIELDGKKIKLQIWDTA 65

  Fly    66 GQERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQ 130
            |||||||||||||||||||:||||||.|:||||||||||||||:|::|||:|::||||::.::|:
Worm    66 GQERFRTITTAYYRGAMGIILVYDITNERSFENIKNWIRNIEEHAASDVERMIIGNKCDIEERRE 130

  Fly   131 VSKERGEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTEKRMEANNPPKGGH-----QLK 190
            ||::||||||||||.||:||||||::|::|||.|||.|||:|    ||.|....||.     ::.
Worm   131 VSRDRGEQLAIEYGTKFLETSAKANLNIDEAFFTLARDIKSK----MEQNEMRAGGSVSNTGRVN 191

  Fly   191 PMDSRT-KDSWLSR--CSLL 207
            ...|.| |.|:.|.  |:||
Worm   192 VGGSGTQKKSFFSNWSCNLL 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_001246837.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	134/165 (81%)
rab-8	NP_491199.2	Rab8_Rab10_Rab13_like	6..172	CDD:206659	134/165 (81%)
rab-8	NP_491199.2	RAB	9..172	CDD:197555	131/162 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167139
Domainoid	1	1.000	277	1.000	Domainoid score	I917
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100934
Inparanoid	1	1.050	301	1.000	Inparanoid score	I1623
Isobase	1	0.950	-	0	Normalized mean entropy	S199
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1426655at2759
OrthoFinder	1	1.000	-	-		FOG0000502
OrthoInspector	1	1.000	-	-		oto19186
orthoMCL	1	0.900	-	-		OOG6_101252
Panther	1	1.100	-	-	LDO	PTHR47980
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1998
SonicParanoid	1	1.000	-	-		X312
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740